Kunming Medical University

Osimertinib With or Without Chemotherapy in Advanced Non–Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations

Importance: Combination therapy has emerged as a promising therapeutic approach for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, its clinical benefit-risk profile remains a focus of ongoing debate. Identifying patients...

Intra‐Bacterial Supramolecular Assembly of Peptide With RNA Activates MRI/Fluorescence Imaging and Avoids Drug Resistance

ABSTRACT Multidrug‐resistant Gram‐negative bacteria present a critical challenge for both diagnosis and therapy because diagnostic and therapeutic molecules have difficulty entering Gram‐negative bacteria, and these molecules can also be expelled by bacteria using efflux pumps. H...

Digital health literacy and attitudes toward aging among older adults in China: evidence of a U-shaped association based on CLASS data

Digital health literacy (DHL) is increasingly important for older adults amid population aging and digital transformation. However, its association with attitudes toward aging and the underlying psychological mechanisms remain unclear. Methods This study used pooled cross-section...

taVNS for uterine contraction pain and early recovery after spontaneous vaginal birth: a three-arm randomized controlled trial protocol

Uterine contraction pain after spontaneous vaginal birth (SVB) hinders early maternal recovery. Transcutaneous auricular vagus nerve stimulation (taVNS), as a safe, and non-invasive alternative therapy, can alleviate pain and improve sleep and emotion. Although a recent trial has...

Glymphatic-meningeal lymphatic dysfunction drives remote organ injury after aneurysmal subarachnoid hemorrhage: a unified neuroimmune framework and time-stratified therapeutic roadmap

Aneurysmal subarachnoid hemorrhage (aSAH) confers substantial mortality and morbidity driven not only by primary brain injury but also by systemic remote organ complications across the pulmonary, cardiac, renal and gastrointestinal systems. Despite growing recognition of neuroimm...

Pregnancy loss and prevalent cardiometabolic multimorbidity: a two-stage individual participant data analysis of CHARLS, ELSA, and HRS

Cardiovascular disease remains the leading cause of death worldwide, and cardiometabolic multimorbidity (CMM) is associated with substantially higher mortality and reduced life expectancy. Pregnancy loss is common and has been linked to later cardiovascular risk, but multinationa...

Escitalopram for psychological symptoms and cardiovascular outcomes in patients with coronary heart disease: a systematic review and meta-analysis of randomized controlled trials

Patients with coronary heart disease (CHD) often have comorbid depression and anxiety, which worsen prognosis. Escitalopram, a selective serotonin reuptake inhibitor, is used for these symptoms, but evidence on its psychological and cardiovascular effects in CHD is limited. This...

Sex-dimorphic phenotypic divergence in metabolically driven thyroid nodules: the interplay of systemic inflammation and adiposity

Metabolic dysfunction has been increasingly implicated in thyroid nodule development; however, the sex-specific interplay between systemic glucolipotoxicity, adiposity, inflammation, and thyroid nodule risk remains poorly understood. This study aimed to evaluate the association b...

A single-nucleus transcriptomic characterization of EGFR G719X/S768I double-mutant lung adenocarcinoma identifies an immunosuppressive niche defined by COL4A3-CD44 interaction

EGFR double mutations (G719X/S768I) represent a clinically recalcitrant subtype of lung adenocarcinoma (LUAD) characterized by diminished tyrosine kinase inhibitor (TKI) sensitivity. However, the specific tumor microenvironment (TME) features and intercelluar crosstalk driving th...

Development of a nomogram for predicting extramural venous invasion in colon cancer using spectral CT multiparameter imaging

Abstract Purpose To develop a predictive model based on spectral CT-derived parameters for preoperative assessment of extramural venous invasion (EMVI) in patients with colon cancer. Methods This retrospective study included 235 patients with pathologically confirmed colon cancer...