King Saud University

“Updates on diagnostic and prognostic molecular biomarkers of CNS tumors”

The diagnosis and classification of central nervous system (CNS) tumors has undergone a paradigm shift over the past decade, evolving from a purely histology-based approach to an integrated framework that incorporates molecular and epigenetic features. This review summarizes rece...

Detection of Two Pospiviroid Species Affecting Tomato and Pepper Crops in Saudi Arabia

During the growing season 2018–2019, a total of 199 tomato and 21 pepper asymptomatic and symptomatic samples were collected from different major regions of Saudi Arabia. Using the general Norgen Kit and universal Pospi1-RE/Pospi1-FW primers for Pospiviroid RT-PCR detection, only...

The Bloch Space over the Upper Half-Plane

In this paper, we represent Bloch functions over the upper half-plane as integrals involving modified Bergman reproducing kernels. This enables us to obtain a precise characterization of the dual space of the Bergman space A1(Π+) in terms of the normalized Bloch space Bi(Π+). Fur...

Enhancing shear capacity of wide RC beams with planted columns: steel rods vs. conventional stirrups

Reinforced concrete (RC) wide beams supporting planted columns are frequently employed in non-seismic regions, particularly throughout the Middle East, to transfer concentrated gravity loads from upper floor levels. However, inadequate shear reinforcement in older or improperly d...

Longitudinal Regional Trends in Healthcare Capacity and Recorded Service Utilization in the Saudi Ministry of Health, 2016–2024

Background/Objectives: Regional monitoring is needed to determine how Ministry of Health (MoH) healthcare supply and recorded service utilization changed during Saudi Arabia’s health-sector transformation. This descriptive study examines selected indicators relevant to Sustainabl...

Vascularized free flaps based oral reconstruction: a narrative review of dental functional outcomes

Oral soft- and hard-tissue defects resulting from oncologic resection, trauma, or other acquired conditions often require complex reconstruction to restore form and function, with vascularized free flaps providing a reliable approach for extensive tissue replacement. Despite thei...

N-Acetylcysteine Attenuates Amikacin-Induced Biochemical, Inflammatory, and Histopathological Alterations in Mice

Background: Amikacin is an effective aminoglycoside antibiotic, but its clinical use is limited by nephrotoxicity, hepatotoxicity, and neurotoxicity. N-acetylcysteine (NAC), a glutathione precursor and antioxidant, may help reduce these side effects. This study evaluated whether...

AI Use for Mental Health Information and Professional Psychological Help-Seeking Intentions Among Saudi Women: A Cross-Sectional Study

Mental health concerns remain a major public health challenge, while artificial intelligence (AI)-based tools are increasingly used to obtain mental health-related information. However, little is known about the relationship between AI use and professional psychological help-seek...

Determinants of incomplete nuclear medicine examinations following radiopharmaceutical administration: A mixed-methods clinical audit at a tertiary hospital in Saudi Arabia

Objective To identify the prevalence and clinical determinants of incomplete nuclear medicine (NM) examinations following radiopharmaceutical administration, and to assess their impact on nuclear medicine practice efficiency and radiopharmaceutical utilization at a tertiary hospi...

MXene-based biosensors for hospital-on-chip diagnostics: a coordination chemistry framework from materials design to clinical translation

MXenes, a rapidly expanding family of two-dimensional transition metal carbides and nitrides, have emerged as promising materials for hospital-on-chip (HoC) diagnostics because of their high electrical conductivity, chemically tunable surfaces, and versatile biofunctionalization....

Stroke incidence and phenotype in Saudi patients with sickle cell disease: A longitudinal cohort study

Summary Stroke is a major cause of morbidity in sickle cell disease (SCD); however, contemporary longitudinal data from Saudi cohorts remain limited. We examined stroke incidence, phenotype and laboratory correlates in 195 patients with homozygous sickle cell anaemia (HbSS) or si...

The efficacy and safety of celecoxib for postoperative pain in major orthopedic surgery: a systematic review and pairwise meta-analysis

Effective postoperative pain management is crucial for surgical recovery, yet opioid-based therapies carry significant risks of addiction and adverse effects. Celecoxib, a selective COX-2 inhibitor, has emerged as a promising non-opioid alternative within multimodal analgesic pro...

Molecular targeting of DNA metabolism by brown algae metabolites in Mycobacterium chelonae: computational analysis via DFT and MD simulations

Mycobacterium chelonae , a member of the rapidly growing mycobacteria, has been linked to a variety of infections, including skin and soft tissue infections, pulmonary disease, and disseminated infections in immunocompromised people. The limited efficacy of current treatments, as...

Combined ROC curves for MRCC-I, MPGES, 8-isoprostane, and cPLA2 increase their discriminative value as biomarkers of autism spectrum disorders

Emerging evidence implicates mitochondrial dysfunction, oxidative stress, and neuroinflammation as key interrelated mechanisms underlying ASD pathophysiology. These molecular disturbances contribute to neuronal dysfunction through a self-reinforcing cycle, wherein mitochondrial i...

GLP-1 Receptor Agonists and Musculoskeletal Outcomes: A Systematic Literature Review and Meta-Analysis

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly used for the treatment of type 2 diabetes and obesity, but their effects on musculoskeletal health remain completely misunderstood. This systematic review/meta-analysis aims to synthesise clinical data on the...

Prevalence of Stress, Anxiety, and Depression Among Pregnant Women in Riyadh, Saudi Arabia

Background & Objective: Pregnancy is a vulnerable period for psychological distress, yet Riyadh-specific data describing stress, anxiety, and depression simultaneously and their correlates remain limited. This study was conducted with aim to estimate the prevalence of antenatal s...

Descemet Membrane Detachment Presenting as Graft Edema After Arcuate Keratotomy in an Eye with Previous Penetrating Keratoplasty—A Case Report

Introduction and Clinical Significance: Descemet membrane detachment (DMD) is an uncommon but potentially vision-threatening complication of anterior segment surgery. Although immune-mediated graft rejection is a recognized cause of postoperative graft edema following arcuate ker...

Morphology and Phylogeny of Four Marine Scuticociliates (Protista, Ciliophora), with Descriptions of Two New Species: Pleuronema elegans spec. nov. and Uronema orientalis spec. nov.

This dataset contains the digitized treatments in Plazi based on the original journal article Pan, Xuming, Huang, Jie, Fan, Xinpeng, Ma, Honggang, Al-Rasheid, Khaled A. S., Miao, Miao, Gao, Feng (2015): Morphology and Phylogeny of Four Marine Scuticociliates (Protista, Ciliophora...

Fulvic acid and hydrogen sulfide synergistically mitigate chromium stress in tobacco seedlings by regulating oxidative stress indicators and antioxidant defense mechanisms

Chromium (Cr) toxicity poses a significant threat to crop growth and agricultural productivity. Fulvic acid (FA) and hydrogen sulfide (HS) have emerged as promising agents for mitigating metal-induced toxicity; however, their combined effects on physiological and biochemical resp...

Efficacy and Safety of Sacituzumab Govitecan for Breast Cancer

Objectives: Sacituzumab govitecan (SG), a Trop-2-directed antibody-drug conjugate, has demonstrated clinical activity in HER2-negative breast cancer. Our meta-analysis aimed to evaluate the efficacy and safety of SG compared with standard chemotherapy in patients with breast canc...