Karolinska Institutet

OA03-RF01.05. The Safety and Efficacy of Endoscopic Submucosal Dissection for Early Esophageal Squamous Cell Carcinoma in Scandinavia (SEES-Study)

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Endoscopic submucosal dissection (ESD) is recommended for early-stage esophageal squamous cell carcinoma (ESCC). Most data on the efficacy of ESD for ESCC comes...

Are sleep and breakfast behaviours predictors of active or independent commuting to school in Spanish youth?

Abstract Background Despite increasing interest in the association between active commuting to school (ACS) and health-related behaviors, the existing literature presents inconsistent findings regarding the relationships between ACS and preceding behaviors such as sleep duration...

Internet-based Emotion Regulation Individual Therapy for Adolescents (IERITA) plus treatment as usual versus treatment as usual for adolescent outpatients with non-suicidal self-injury—the TEENS multi-site trial: study protocol and statistical analysis plan for a multi-site randomised clinical trial

Non-suicidal self-injury (NSSI) is a public health concern and a widespread behaviour, especially among adolescents. NSSI is an indicator of psychological distress and a known risk factor for later suicidal behaviour and death by suicide; however, evidence-based treatment options...

P1.004. Cryoablation of Barrett´s Esophagus in Patients not Suitable for Treatment With Radiofrequency Ablation

Abstract Topic Benign Disease: Barrett’s Esophagus: Pathology and Pathophysiology; Non-invasive Neoplasia Background Radiofrequency ablation (RFA) is the gold standard for ablation of the esophagus. However, there are occasions when RFA is not suitable, for example if the patient...

P1.123. Deep Learning and Machine Learning Radiomics-Based Models Predicting Esophagogastric Cancer Recurrence: A Systematic Review

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Esophageal and gastric cancers are associated with recurrence rates approaching 50% despite curative-intent treatment. Non-invasive imaging modalities including computed tomography (CT), positron emission tom...

P1.005. Preliminary Pilot Study Cohort Results - Cost-Effective Surveillance Strategies and Prediction of Cancer Recurrence After Endoscopic Therapy for Barrett’s Esophagus (Endeavor)

Abstract Topic Esophageal Cancer: Barrett‘s Esophagus: High-Grade Dysplasia and Early Invasive Cancer Background In many European countries, esophageal adenocarcinoma (EAC) incidence is increasing [1]. Barrett’s esophagus(BE), strongly associated with EAC, can progress via dyspla...

Familial Co‐Aggregation of Neurodevelopmental Conditions and Childhood‐Onset Type 1 Diabetes

ABSTRACT Aim Childhood‐onset Type 1 diabetes (T1D) is associated with neurodevelopmental conditions (NDCs). We examined whether this association extends to relatives and assessed phenotypic, genetic, and environmental correlations between T1D and NDCs. Methods Using Swedish regis...

Accelerating protein design by scaling experimental characterization

Abstract Recent advances in de novo protein design have greatly outpaced standard protein biochemistry workflows, and experimental testing has been a bottleneck in the validation of new designs and methodologies. Here, we describe experimental and computational workflows to addre...

High-Ratio Partial Proteolysis with Carrier Proteome (HOLSER) Enables Global Structure Profiling and Site-Resolved Elucidation of Ligand-Protein Interactions.

Understanding how cellular proteins interact with their environment, including endogenous and exogenous molecules, is critical for elucidating mechanisms of cellular regulation and drug action. Partial proteolysis-based techniques offer peptide-level resolution of ligand-induced...

Modulation of neuronal excitability and plasticity by BHLHE41 conveys lithium non-responsiveness

Abstract Many bipolar disorder (BD) patients are non-responsive to lithium. The mechanisms underlying lithium (non-)responsiveness are largely unknown. By using gene-set enrichment analysis methods, we found that core clock gene-sets are significantly associated with lithium resp...

Clinical outcomes and opportunities for improvement across modified trauma quality improvement cohorts: a registry-based cohort study

<title>Abstract</title> Background The American College of Surgeons Trauma Quality Improvement Program (TQIP) relies primarily on risk-adjusted mortality benchmarking, yet mortality alone may overlook non-fatal morbidity and care-process failures, particularly in cohorts where ou...

Association of baseline and cumulative cholesterol–high-density lipoprotein–glucose index with cardiometabolic multimorbidity: prospective evidence from two cohort studies

Abstract Introduction Cardiometabolic multimorbidity (CMM) is increasingly common and carries substantial clinical and public-health burden. The cholesterol-high-density lipoprotein-glucose (CHG) index has been linked to adverse cardiometabolic outcomes, but prospective evidence...

Association of pre-clinical depressive symptoms and its plasma metabolomic signature with Parkinson’s disease: a community-based longitudinal study

Abstract Accumulating evidence has suggested that depression is associated with an increased risk of Parkinson’s disease (PD), yet whether pre-clinical depressive symptoms in PD development and the potential mediating effects of metabolomic profiles remain unclear. We aimed to ex...

Data-Driven Fatigue Trajectories in Multiple Sclerosis and Their Predictors

Fatigue is one of the most disabling symptoms of multiple sclerosis (MS), yet its longitudinal trajectories and determinants remain poorly characterized. We aimed to identify trajectories of cognitive and physical fatigue in relapsing-remitting MS (RRMS) and to determine baseline...

Trajectories of refraction and strabismus from 2.5 to 12 years in a national cohort of extremely preterm children‐ the Extremely Preterm Infants in Sweden Study (EXPRESS)

Abstract Purpose To investigate the longitudinal development of refraction and strabismus in a national cohort of children born extremely preterm (EPT) and find relations to perinatal events and neurodevelopmental outcomes. Methods All surviving children born &lt;27‐gestation wee...

Gemfibrozil promotes longevity and health by restricting amino acid uptake through the Dipeptide transporter, PEPT1

The FDA-approved fibrate, gemfibrozil, has been used clinically to treat hyperlipidaemia, showing efficacy both in lowering triglycerides and increasing high-density lipoproteins. However, in recent years, the drug has been increasingly investigated for potential clinical use in...

Dysregulated lncRNAs are associated with the progressive arterial phenotype in Hutchinson–Gilford Progeria Syndrome

Hutchinson–Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused by de novo LMNA mutations. Patients develop severe systemic symptoms limiting life quality and ultimately causing death from cardiovascular events. Despite extensive research, treatment options...

Mobile genetic elements as strain-specific markers: a case study in Shewanella sp. Pdp11

Abstract Strain-level identification is a key challenge in microbiology, particularly for monitoring microorganisms of interest such as probiotics. Traditional methods based on 16S rRNA gene sequencing often lack the resolution to discriminate closely related strains. This study...

Associations between organizational readiness and implementation fidelity in national implementation of WHO’s labour care guide in Sweden: a prospective observational study

Abstract Background During 2024 and 2025, an adapted version of the World Health Organization’s Labour Care Guide was implemented in approximately half of Sweden’s labor wards within the PICRINO trial. Organizational readiness is widely regarded as a key determinant of successful...

Enzymatic degradation of conjugated polymer thin films for electrochemical transistors

Degradable imine linkers within the polymer backbone enabled acid-triggered organic mixed ionic–electronic conductors (OMIECs). Yet, for many bioelectronic applications, OMIECs must work in direct contact with physiological fluids, making it challenging to achieve both excellent...