Johannes Gutenberg University Mainz

Time-resolved imaging of antiferromagnetic skyrmion interactions

Abstract Quantifying particle interactions is central to understanding and controlling collective dynamics in particle-based devices such as those comprising skyrmion ensembles. Here we directly visualize, in real time, the nanosecond current-driven dynamics of an antiferromagnet...

Oxygen-UnaffectedTemperature Sensing in Air-SaturatedAqueous Dispersion with Oxygen-Sensitive Luminescent Metal ComplexesEncapsulated in l -Arginine-Type Silica Networks

Abstract Bioimaging, sensing, and photonic applications of oxygen-sensitive luminophores such as near-infrared (NIR) emissive spin-flip complexes of earth-abundant chromium (CrIII) and triplet metal-to-ligand charge transfer complexes like ruthenium (RuII), osmium (OsII) or iridi...

Caregiver-reported experience of integrated care for children with special health care needs and its sociodemographic, health- and network-related correlates in Germany: Cross-sectional results from the PART-CHILD cohort

Abstract Background Children with special health care needs (CSHCN) often rely on cross-sectoral care networks involving medical, therapeutic, educational, and social services. However, key dimensions of integrated care, including cross-sectoral communication and attention to fam...

The Plasmodium heme detoxification protein functions in mitochondrial protein synthesis

Abstract Malaria blood-stage parasites digest ~80% of host cell hemoglobin within a degradative vacuole, releasing heme that is detoxified by sequestration into hemozoin crystals. Although essential for survival and a validated drug target, the mechanisms of heme biomineralizatio...

Two-year efficacy and safety outcomes of the Paul Glaucoma Implant compared to the Ahmed Glaucoma Valve

PURPOSE: To compare efficacy and safety profiles of the Paul Glaucoma Implant (PGI) and Ahmed Glaucoma Valve (AGV) in the treatment of adults with glaucoma over a 2-year of follow-up period. METHODS: This retrospective, single-center, comparative study included adult patients who...

Calr-mediated calcium buffering: a molecular barrier to in vivo cardiac reprogramming

In a recent publication in Cell Stem Cell , Cai et al. 1 employed an in vivo Perturb-seq strategy to systematically identify molecular barriers that limit direct cardiac reprogramming following myocardial infarction (MI). This study provides a conceptual and technological framewo...

Global stability and uniform persistence in an epidemic model with saturating fomite-mediated transmission

Abstract We analyse the global dynamics of a Susceptible–Vaccinated–Exposed–Infected–Recovered (SVEIR) epidemic model with demographic turnover, imperfect vaccination, and two transmission routes: direct host-to-host contagion and indirect transmission via contaminated fomites. I...

Queen loss fails to elicit physiological and transcriptional responses in workers of the invasive garden ant Lasius neglectus.

Colonies of insects with morphologically distinct castes have been called superorganisms because the function of their queens and workers is analogous to the germline and soma in metazoan bodies. In the case of formicoid ants, workers typically have lost the sperm storage organ,...

Real-world walking and activity patterns in community-dwelling older adults: a cross-sectional analysis of baseline data from the SMART-AGE trial

Abstract Background Digital mobility outcomes (DMOs) measured under real-world conditions allow for differentiated insights into mobility patterns of older adults. This study provides an advanced description of real-world walking in community-dwelling older adults and identifies...

Monolithic Porous Polymer Architectures for Visible‐to‐UV Upconversion‐Driven Photochemical Reactions

ABSTRACT Triplet–triplet annihilation‐based photon upconversion (TTA‐UC) expands the accessible spectral window for photochemical transformations by generating high‐energy photons from low‐energy excitation. Although TTA‐UC has been widely demonstrated in solution and in various...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Machine Learning-Based Prediction of Six-Minute Walk Distance in Children with Obesity

Background: The six-minute walk test (6MWT) assesses functional exercise capacity, but existing reference equations for children with obesity rely on traditional linear regression, potentially overlooking complex, non-linear relationships between anthropometric characteristics an...

Effective Reductionof Anti-PEG Antibody Recognitionvia PEG Copolymers with Ethyl Glycidyl Ether and Isopropyl GlycidylEther

Abstract Anti-PEG antibodies (APAs) lead to accelerated blood clearance of PEGylated drugs and nanocarriers. Randomized PEG (rPEG) reduces APA recognition by randomly incorporating glycidyl methyl ether in PEG. Extending this concept, statistical copolymerization of ethylene oxid...

Beam steering and radiation generation of electrons in bent crystals in the sub-GeV domain

Abstract We present an investigation into beam steering and radiation emission by sub-GeV electrons traversing a bent silicon crystal. Using 855, 600, and 300 MeV electron beams at the Mainz Microtron (MAMI), we explored orientational coherent effects in a 15- $$\upmu $$ <mml:mat...

A critical review of the early clozapine trials published in German and a discussion of the many unresolved issues left by these trials

Clozapine was (1) first introduced in Austria and Switzerland in 1972, (2) associated with 8 Finnish deaths due to agranulocytosis in 1975 (almost leading to its withdrawal), and (3) approved in the United States (US) for treatment-resistant schizophrenia in 1989 (resulting in a...