Johannes Gutenberg University Mainz

Polymer Knots in Thin Slit-Confined Melts: Thickness Dependence, Local Effects, and Stiffness

Abstract We study how confinement affects topology and conformations in flexible and semiflexible slit-confined polymer melts of varying thickness h. The knotting probability exhibits a maximum at intermediate thicknesses near the bulk radius of gyration h ≈ Rg,bulk, vanishes at...

Biomass Burning in Australia: No Evidence for Carbonyl Sulfide (OCS) Enhancement in Fire Plumes From In‐Situ Measurements During SouthTRAC

Abstract Determining the atmospheric abundance and the emission sources of carbonyl sulfide (OCS) plays a crucial role for the sulfur budget in the atmosphere. In addition to its main anthropogenic and biogenic sources, biomass burning is assumed to be an essential, but not well...

Linking molecular composition of organic aerosols to reactive oxygen species formation using an MCR-VK framework

Abstract. Reactive oxygen species (ROS) formation by atmospheric fine particulate matter (PM) is widely implicated in adverse health effects, yet the molecular determinants of particle-level ROS formation remain poorly constrained, largely due to the chemical complexity of organi...

Trends in glaucoma diagnosis and medical management in Germany: A nationwide claims data analysis over 10 years

Abstract Purpose Analysing longitudinal trends in recorded diagnosis and medical management of glaucoma in Germany over a 10‐year period. Methods A retrospective cohort study using nationwide outpatient claims and prescription data from the German statutory health insurance syste...

Task-specific theta enhancement and domain-general alpha/beta suppression as oscillatory signatures of cognitive flexibility

Abstract Cognitive flexibility–the ability to adapt to changing situational or task demands–is a fundamental aspect of human cognition and a potential source of individual differences in higher-order cognitive abilities. To further understand the neural mechanisms underlying this...

Disease Duration Differentiates Freezing of Gait Response to Subthalamic and Nigral Stimulation for Parkinson's Disease in an Exploratory Multicenter Controlled Trial

BACKGROUND: Freezing of gait (FoG) belongs to most pressing unmet symptoms in the treatment of Parkinson's disease. OBJECTIVES: To explore whether combined subthalamic and nigral (STN + SNr) deep brain stimulation improves FoG compared with optimized STN stimulation alone; to ide...

RNA Organelles in DNA‐Based Artificial Cells Provide Spatial Aptamer Functions and Enhanced Signal Processing

ABSTRACT Naturally occurring biomolecular condensates orchestrate key cellular processes by creating spatially distinct reaction environments, yet engineering synthetic condensates that combine structural programmability with spatioselectively encoded function remains challenging...

RNA Organelles in DNA‐Based Artificial Cells Provide Spatial Aptamer Functions and Enhanced Signal Processing

ABSTRACT Naturally occurring biomolecular condensates orchestrate key cellular processes by creating spatially distinct reaction environments, yet engineering synthetic condensates that combine structural programmability with spatioselectively encoded function remains challenging...

Exploring Family Interactions: Heterogeneity in Family Specific Network Models

ABSTRACT Daily family interactions have a profound impact on children's emotional and behavioral development. While extensive research highlights the detrimental effects of negative parenting practices and the benefits of positive parenting programs, less is known about the compl...

Short Dental Implants as Strategic Support for Removable Partial Dentures in Mandibular Free‐End Situations: A 3‐Year Prospective Cohort Study

ABSTRACT Objectives This study aimed to assess the mid‐term clinical performance of short implants as strategic support for mandibular removable partial dentures (RPDs) with free‐end situations. Methods Subjects wearing lower RPDs in Kennedy Class I situations received two suppor...

FIND: a phase-II study to evaluate the efficacy and safety of erdafitinib in FGFR-altered NSCLC

Abstract Introduction: FGFR alterations occur in approximately 2% of non-small cell lung cancer (NSCLC) patients, predominantly in squamous cell histology (sqNSCLC). We evaluated the efficacy of the selective FGFR1-4 inhibitor erdafitinib in patients with FGFR-altered NSCLC. Meth...

From Single-Chain Dynamics to Structure Formation: Dynamic Self-Consistent Field Theory and Molecular Dynamics of (Co)polymer Melts across Entanglement Regimes

Abstract Dynamic self-consistent field theory (DSCFT) provides an efficient continuum framework for studying structure formation in inhomogeneous polymer systems, but its predictive accuracy depends on the choice of nonlocal mobilities. Here, we construct mobility functions for m...

Self-modulation of photoemission at the picosecond time scale

The pulse response of negative electron affinity GaAs photocathode over a wide range of quantum efficiencies has been measured. Low quantum efficiencies, where an intense excitation is needed, may lead to rapid dynamic change of the transport conditions on a time scale of a few p...

Observation of relativistic bond weakening in seaborgium hexacarbonyl

Abstract The seventh row of the periodic table of the elements has been completed with the discovery of the five heaviest elements from flerovium (Fl, Z = 114) through oganesson (Og, Z = 118) 1 . Chemical properties of the superheavy elements (SHE, Z ≥ 104) are unique owing to th...

Critical windows: timing of child maltreatment exposure and adult mental health

Abstract Background Despite being recognized as the leading risk factor for mental disorders, child maltreatment (CM) remains insufficiently understood regarding type and timing of exposure. This study examines which developmental periods of exposure to CM subtypes are most stron...

Recurrence patterns and survival outcomes in advanced papillary thyroid carcinoma: a retrospective cohort analysis

Abstract Papillary thyroid carcinoma (PTC) is the most common malignant thyroid tumor, with a small proportion of patients presenting with advanced disease. The recent European Society of Endocrine Surgeons (ESES) consensus introduced a refined definition of advanced thyroid canc...

Reevaluating the empirical support for a lens-based account: dissecting comparative fit and reconstructive category guessing

The lens-based account of intersectional stereotyping (Petsko et al., 2022) proposes that perceivers put on social “lenses” for categorizing their environment that exhibit comparative fit with observed behavior in a given situation. Support for this claim comes from studies using...

Interdependence of dental parameters, mandibular mobility and static postural sway as well as load distribution in male subjects of advanced working age

Abstract Background Maintaining static postural sway as well as load distribution is an essential component of overall physical stability in older age. The temporomandibular system is a measurable influencing factor due to functional interdependencies, although it has not yet bee...

Neuropsychobiological transdiagnostic risk mechanisms for aggression in mental disorders across the life span

Abstract Background Aggression in mental disorders (AMD) is a prevalent symptom, poses difficulties to the clinical setting and has far-reaching societal implications. The biological basis of different manifestations, developmental courses, and disease-specific mechanisms remains...

PfATG18 links V-ATPase assembly to endocytic membrane dynamics in malaria parasites

Malaria parasites replicate inside red blood cells, degrading hemoglobin within a specialized digestive vacuole. Efficient hemoglobin processing is essential for parasite survival and influences antimalarial drug susceptibility. The vacuole constantly fuses with incoming hemoglob...