Johannes Gutenberg University Mainz

PfATG18 links V-ATPase assembly to endocytic membrane dynamics in malaria parasites

Malaria parasites replicate inside red blood cells, degrading hemoglobin within a specialized digestive vacuole. Efficient hemoglobin processing is essential for parasite survival and influences antimalarial drug susceptibility. The vacuole constantly fuses with incoming hemoglob...

Improving patient communication and understanding of medical reports through text simplification with ChatGPT: a comparative study

PURPOSE: Medical documentation is essential for clinical communication but is often intended for professional audiences, limiting patient understanding. This linguistic complexity can reduce health literacy and hinder shared decision-making. Large language models offer new opport...

Lysed erythrocyte membranes metabolically prime endothelial cells for angiogenesis

Endothelial dysfunction is a hallmark of pathological angiogenesis and associated with erythrocyte extravasation and lysis. Whether mediators released from lysed erythrocytes instruct endothelial cells (ECs) for new vessel formation is unknown. Here, we show that the membrane fra...

Isotope- and Element-Resolved Analysis of (Trans)uranium Content of Curium Targets for Heavy-Actinide Production after Intense Neutron Irradiation in the High Flux Isotope Reactor

Abstract Curium is the heaviest element resulting from nuclear power generation and is present in spent nuclear fuel. Macroscopic amounts of transcurium elements are produced by high thermal-neutron flux irradiation of curium targets in a complex process involving many neutron ca...

The effect of dance movement therapy on traumatized refugee women – a clinical controlled trial

Abstract Background Women worldwide are fleeing war, persecution and violence. Typically, they experienced multiple traumata in the home country, on the way, and in the host country. In Germany, less than 10% of the refugees in need receive mental health treatment. Dance movement...

Review of Weigand (2026): Principles of New Science. Dialogue in the stream of life

Abstract This review article critically examines Edda Weigand’s New Science (2026), which reconceptualises scientific inquiry as a science of complexity grounded in human competence-in-performance and dialogic action “in the stream of life”. Moving beyond traditional method-drive...

Deep Learning-Based Image Reconstruction in Ultra-High-Resolution CT Venography for Improved Visualization of Cerebral Venous Drainage

Abstract Purpose To evaluate the diagnostic confidence and image quality of deep-learning-enhanced ultra-high-resolution CT venography (CTV) in venous neurovascular imaging, compared with hybrid iterative reconstruction of ultra-high-resolution CT datasets and normal-resolution C...

A Statistical Perspective on Transformers for Small Longitudinal Cohort Data

ABSTRACT Modeling of longitudinal cohort data typically involves complex temporal dependencies between multiple variables. There, the transformer architecture, which has been highly successful in language and vision applications, allows us to account for the fact that the most re...

The Protective Effect of Chlorella vulgaris Supplement Against Mercury Exposure Is Associated with DMT1: A Transcriptomic Analysis

Daily supplements have emerged as a compelling strategy for heavy metal detoxification (e.g., Hg and Pb), given that conventional chelation therapy lacks chronic exposure data and is heavily reliant on the doctor’s experience. Among such natural agents, Chlorella vulgaris (C. vul...

War-related and psychological predictors of experiential and physiological fear of war in Germany: findings from a nationally representative survey

Abstract Background Fear of war has emerged as a relevant psychosocial phenomenon in Europe, yet little is known about factors associated with its experiential and physiological dimensions in representative populations. This study examined sociodemographic, war-related, and psych...

Ultrastructural Signatures of Amikacin Neurotoxicity and the Protective Modulation of Memantine in Peripheral Nerves: A Transmission Electron Microscopy Exploration in Wistar Rats

Background/Objectives: Aminoglycoside antibiotics such as amikacin are indispensable for treating severe Gram-negative infections, but their clinical use is limited by a well-documented toxicity profile that has focused overwhelmingly on ototoxicity and nephrotoxicity, leaving th...

FAIR Chemistry Data: An Adoptable and Easy-to-Use Workshop Concept for RDM Training

This poster presentation and the associated abstracts belong to the "Fellowship of the Data — International RDM Community Meeting 2026" (datafellows.univie.ac.at/) taking place in Vienna on September 21 and 22, 2026, and to the "Data Stewardship in Germany Community Meeting 2026"...

FAIR Chemistry Data: An Adoptable and Easy-to-Use Workshop Concept for RDM Training

This poster presentation and the associated abstracts belong to the "Fellowship of the Data — International RDM Community Meeting 2026" (datafellows.univie.ac.at/) taking place in Vienna on September 21 and 22, 2026, and to the "Data Stewardship in Germany Community Meeting 2026"...

Psychotherapy remission prediction models show limited cross-clinic generalizability in routine outpatient care

Abstract Clinical prediction models for psychotherapy outcomes have the potential to assist therapists in planning a patient’s individual treatment, but their clinical utility depends on maintaining predictive performance across settings. We assessed prediction of post-treatment...

Microscopic field theory for active Brownian particles with translational and rotational inertia

Abstract While active matter physics has traditionally focused on particles with overdamped dynamics, recent years have seen an increase of experimental and theoretical work on active systems with inertia. This also leads to an increased need for theoretical models that describe...

Mitigating aviation’s environmental impact through alternative fuels and cleaner engines

Lean-burn engines are designed to reduce emissions, and sustainable alternative fuels provide additional potential for lowering particle emissions. However, the magnitude of the benefits from these mitigation levers remains poorly constrained, limiting robust predictions of aviat...

Scientific Competence in Undergraduate Medical Education: Professional Orientations of Physiology Educators

Introduction: Scientific Competence (SC) is a central objective in medical education, but its conceptualization remains insufficiently differentiated, particularly regarding the relationship between evidence use and participation in scientific knowledge generation. Objective: Thi...

Quantitative proteomics reveals coordinated changes in the proteome during replicative senescence

Abstract Cellular senescence is a state of irreversible cell cycle arrest triggered by telomere erosion, persistent DNA damage or chronic stress. The accumulation of senescent cells disrupts tissue function and contributes to aging and disease. Here, we employ mass spectrometry-b...

Road transport of trapped antiprotons

Abstract Low-energy antiprotons confined in ultrahigh-vacuum Penning traps 1 enable precision investigations of charge, parity and time-reversal (CPT) invariance 2 to test the fundamental symmetry between matter and antimatter. These studies are driven by the search for physics b...

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

ABSTRACT Climate change has intensified drought frequency and severity, threatening global food security, particularly for staple crops like maize, wheat, and soybean. As central secondary metabolites, flavonoids orchestrate cellular redox homeostasis, stress signal transduction,...