Imperial College London

Interfacial Electronic Regulation of GO/Na0.5Bi2.5Nb2O9 Aurivillius-Layered Perovskite Heterointerfaces for Enhanced Photocatalysis

Constructing heterointerfaces between semiconductor photocatalysts and carbonaceous materials is an effective strategy for enhancing photocatalytic performance. However, the role of graphene oxide (GO) in modulating the interfacial electronic properties of Aurivillius-layered per...

Population genomics, resistome and plasmidome of invasive Klebsiella pneumoniae isolates in adults hospitalised in Johannesburg, South Africa

Abstract Klebsiella pneumoniae (KPn) is a leading cause of healthcare-associated infections in adults in low- and middle-income countries. We conducted laboratory-based surveillance between 2023 and 2024 in Johannesburg, South Africa, and analysed 508 KPn whole genomes isolated f...

Enhancing nasal irrigation adherence through a multimodal health communication strategy: a phased improvement study

Abstract The adherence of chronic rhinitis patients to self-administered treatments is generally very low, which often presents a significant challenge in healthcare. The adherence of chronic rhinitis patients to regular nasal irrigation hygiene care is even lower. Therefore, in...

Benchmarking UK Lynch syndrome colonoscopy surveillance: quality metrics and diagnostic yield from the National Endoscopy Database

Abstract Colonoscopy quality and diagnostic outcomes in Lynch syndrome have historically been heterogeneous. Following the introduction of the Lynch syndrome Bowel Cancer Screening Programme (BCSP), we assessed colonoscopy quality and diagnostic yield in Lynch syndrome using the...

Kidney transplantation in older people (KTOP): a longitudinal, qualitative study of kidney transplant experiences in older, frail adults

Abstract Background Transplantation rates are increasing in those who are older and frail, driven by an aging dialysis population. This longitudinal, qualitative study explores how older adults navigate the journey from dialysis to transplantation and how frailty is experienced a...

Risks of adverse respiratory outcomes in adults with cancer over the course of survivorship compared with cancer-free individuals: a matched cohort study using linked English electronic health records

Background We aimed to compare the risks of developing new chronic respiratory conditions, or exacerbating existing ones in survivors of 20 common cancers vs. cancer-free individuals. Methods We conducted a population-based matched cohort study using English electronic primary ca...

Navigating regulatory fragmentation in the convergence of synthetic biology, artificial intelligence, and automation

The convergence of synthetic biology, artificial intelligence (AI), and automation (SynBioxAI) creates research activities that simultaneously engage biosecurity, AI governance, export control, and data sovereignty frameworks – none of which are designed for convergent science. W...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Live Attenuated Influenza Vaccine (LAIV) for Children for the Prevention of Influenza Illness in Sweden: A Cost-Effectiveness Analysis

Both inactivated influenza vaccine and live attenuated influenza vaccine (LAIV) (indicated for use in children aged 2–17 years) effectively prevent influenza transmission and related outcomes. Despite high transmission among children, vaccination practices in Sweden focus primari...

How Do Climatic Factors Directly Influence the Incidence and Risk of Meningococcal Meningitis Across the African Meningitis Belt? A Narrative Literature Review

Abstract Globally, the highest incidence of meningococcal meningitis occurs within the African meningitis belt, spanning 26 countries across sub‐Saharan Africa. Meningococcal meningitis incidence is highly seasonal in this region specifically, with outbreaks mostly occurring duri...

Dual-Targeted Therapy in Refractory Pyoderma Gangrenosum: A Focused Systematic Review of Convergent Pathway Targeting

Refractory pyoderma gangrenosum (PG) may persist despite corticosteroids, ciclosporin, biologics or sequential treatment escalation. Dual-targeted therapy (DTT) is increasingly used in medically complex inflammatory bowel disease (IBD), but PG is often recorded only as an extrain...

Parabens and estrogen-mediated cancers: unraveling coincidence, co-occurrence, and causality

Abstract Paraben esters are endocrine disruptors linked to breast cancer, yet their role in other estrogen-mediated cancers remains limited. Preclinical evidence suggests that parabens accumulate in tissues and may promote carcinogenesis, while clinical data indicate widespread e...

The role of Mediterranean diet adherence, smoking and their interactions in epigenetic age acceleration: A cross-sectional analysis of the Airwave cohort

ABSTRACT Background Epigenetic clocks are markers of biological aging that may vary in their sensitivity to environmental stressors and lifestyle modifiers. To evaluate the utility of these biomarkers as sensors of the human exposome, we investigated how they respond to two power...

Estimating the environmental impact of an HPC job – tools and challenges

Researchers and research funders are increasingly interested in understanding the environmental impacts of computational research, including impacts through both energy-intensive computations and the production and disposal of specialised computing hardware. However, these impact...

High‐Temperature Alloys in Aeroengines: Damage and Fracture Insights From Micromechanical Modeling

ABSTRACT High‐temperature alloys are the cornerstone of aeroengine hot‐section components, where extreme thermomechanical conditions give rise to intricate damage and fracture behaviors that critically limit the structural integrity of whole aeroengines. Generally, Ni‐based super...

A liquid handling platform for standardised quantification of cell-free enzymatic activity encoded by antimicrobial resistance genes

ABSTRACT Antimicrobial resistance (AMR) is a growing global threat to human health, and rapid methods for characterising emerging antimicrobial resistance genes (ARGs) are needed. Here, we develop a semi-automated workflow using cell-free gene expression (CFE) systems to measure...

A Review of Artificial Intelligence in Composite Finite Element Impact Damage Modelling: A Five-Role Lifecycle Framework

Abstract Finite Element (FE) simulation of impact damage in fibre-reinforced composite laminates is constrained by high computational cost, many difficult-to-calibrate material parameters and the absence of experimental evidence for different composite structures. Artificial Inte...

Engagement in women’s health: a history

In parts of the world, patient and public involvement has become an essential part of health and research. In women’s health and research, there is a chronic lack of participation and inclusion of women throughout the research pathway. At the same time, the gender gap and bias in...

22 Quality of life and services use in patients diagnosed with brain tumours: data from a national cancer survivorship study

Abstract Introduction About 13,000 new patients are diagnosed annually with a primary brain tumour in the UK and less than 20% of patients survive 10 years post-diagnosis. Patient-Reported Outcomes and Experiences (PROMs & PREMs) are largely used in clinical trials that recruit f...

U-Net-based hybrid framework for accelerating deterministic rough-surface mixed lubrication simulations

Abstract Despite significant advances in deterministic mixed lubrication modelling, the computational complexity of these simulations remains prohibitive, limiting their practical use in rapid analysis and design optimisation. This study addresses this bottleneck by developing a...