Goethe University Frankfurt

Genomic insights into the persistence of Nubian giraffe (Giraffa camelopardalis camelopardalis) in conflict-affected South Sudan

Abstract Armed conflicts can severely disrupt wildlife conservation and management, yet their long-term genomic consequences remain poorly understood. South Sudan has experienced decades of conflict that have limited conservation efforts and prevented genomic assessment of its fa...

Functional characterization of snoRNA-derived RNA (sdRNA) expression in healthy hematopoiesis and acute myeloid leukemia

Abstract SnoRNAs are highly expressed in AML and have implications in leukemogenesis and leukemic maintenance. SnoRNAs can be further processed into snoRNA-derived RNAs (sdRNAs). The role of sdRNAs in AML and healthy hematopoiesis remains largely elusive. We characterized sdRNA a...

Clinical outcomes and toxicity of electron-based intraoperative radiotherapy for partial breast irradiation: a single-institution experience

Purpose: Partial breast irradiation (PBI) using intraoperative electron radiotherapy (IOeRT) represents an attractive alternative to whole-breast irradiation in carefully selected patients with early breast cancer. Materials and Methods: Eighty-nine patients treated with single-d...

Reconstitution of multistep recruitment of ULK1 to membranes in autophagy

Abstract The Human ULK1 autophagy-initiating complex consists of ULK1, FIP200, and the HORMA domain heterodimer ATG13:ATG101. PI3P is essential to recruit ULK1C to membranes for ULK1, but ULK1C subunits do not contain PI3P-binding domains. Here we show that the ATG13:ATG101 dimer...

Nationwide trends in incidence and in-hospital mortality of ARDS in Germany, 2008–2022

Abstract Acute respiratory distress syndrome (ARDS) remains a major contributor to morbidity and mortality among critically ill patients. Recent events such as the COVID-19 pandemic and demographic changes have likely influenced its epidemiology. This study aimed to investigate n...

How many bromeliads are there? History and future perspectives of species scientific discovery in the pineapple family

Societal Impact Statement It remains unclear how many plant species are not yet recorded by science. We illustrated the process by which species of the pineapple family in tropical America have been newly described to science to date, and we estimated how many species may still a...

On variability in local field potentials

Abstract Neuronal coding and decoding would be compromised if neuronal responses were highly variable. Intriguingly, neuronal spike counts (SCs) show a reduction in across-trial variance (ATV) in response to sensory stimulation, when SC variance is normalized by SC mean, that is,...

Lack of evidence for gene-level convergence linked to evolutionary shifts in torpor among placental mammals

Torpor is a key survival strategy that many avian and mammalian lineages evolved in response to challenging environmental conditions. Whether the independent evolution of torpor in different lineages involved changes in the same genes remains poorly understood. Here, we performed...

Extending the computational reach of quantum annealing using reverse annealing

Abstract Quantum annealing is a promising heuristic for combinatorial optimization, but on current hardware its solution quality degrades for larger and more complex problems due to noise and small energy gaps. Reverse annealing has been established as a refinement strategy, yet...

Phosphorylation Protects Oncogenic RAS from LZTR1-Mediated Degradation

Oncogenic KRAS and NRAS mutations are common in hematologic malignancies, but how they signal is less well characterized than in carcinomas. To uncover novel RAS biology and potential therapeutic vulnerabilities, we employed a multi-omics screening approach in multiple myeloma to...

Multiscale patterns of migration flows in Austria: regionalization, administrative barriers, and urban-rural divides

Abstract Migration is central to various societal problems related to socioeconomic development. While much of the existing research has focused on international migration, migration patterns within a single country remain relatively unexplored. In this work, we study internal mi...

Timing of PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation

BackgroundApproximately one half of patients undergoing transcatheter aortic-valve implantation (TAVI) have concomitant coronary artery disease. Although percutaneous coronary intervention (PCI) is often performed before TAVI, the preferred treatment strategy has not been establi...

Tricuspid-Valve Intervention in Heart Failure

BackgroundThe effect of transcatheter tricuspid-valve repair on clinical outcomes, including death and hospitalization for heart failure, in patients with severe tricuspid regurgitation remains uncertain. MethodsWe randomly assigned patients with symptomatic severe tricuspid regu...

A'mmomat and weshu processing as a mechanism of balancing gender power relations among the Kambaata community of Central Ethiopia

Abstract This article argues that power in gender relations within the Kambaata people of central Ethiopia is expressed through relational, mutual, and complementary dynamics rather than domination or control. It critiques Western liberal feminist frameworks—especially those emph...

Series approximations of the polylogarithm with applications to Euler sums and certain integrals

Abstract A series approximation of the polylogarithm based on values of the Riemann zeta function is proposed, and truncation of this series yields finite approximations of the polylogarithm. Both the series representation and its truncated versions of the series are applied to c...

Developing a core competency framework for psychiatric pharmacists: a Europe-wide e-Delphi consensus study conducted by the European Society of Clinical Pharmacy Mental Health Special Interest Group

Abstract Introduction Consensus on essential clinical activities of psychiatric pharmacists is currently unavailable. Agreement on core non-clinical roles relating to research, education, leadership and management is also unavailable. Consensus on the core clinical and non-clinic...

Oncofetal cell states: cell plasticity drives invasion in premetastatic colorectal tumors

In a recent publication in Nature , Buissant des Amorie et al. provide evidence that an oncofetal cell state which is associated with advanced disease, chemoresistance and metastatic competence emerges already in early-stage T1 colorectal cancer (CRC). Intriguingly, oncofetal cel...

Incident psoriasis in atopic dermatitis: a large-scale cohort study of disease- and treatment-associated risks

Abstract Background Clinical and genetic evidence on the association between atopic dermatitis (AD) and subsequent psoriasis remains conflicting, and it is unclear whether this risk is modified by systemic treatments. Recent reports suggest type 2-targeted biologics may unmask ps...

Addressing anthropogenic noise and electrical anisotropy hints in magnetotelluric data from the Annecy area (French Pre-Alps)

The magnetotelluric (MT) method is a widely used tool for geothermal reservoir exploration due to its capability of imaging fluids in the Earth’s crust. However, in urbanised environments, its application is often challenged by anthropogenic noise and low signal-to-noise ratios....

Pediatric intensive care follow-up in Germany is rarely established and highly heterogeneous: a nationwide survey of 20 PICUs

BACKGROUND: Survival after pediatric critical illness has improved substantially, but many survivors and their families experience long-term physical, neurocognitive, psychological and social sequelae, summarized as post-intensive care syndrome in pediatrics and in families. Stru...