Goethe University Frankfurt

A comprehensive look at Respiratory Syncytial Virus (RSV): from pathogenesis to prevention

Respiratory Syncytial Virus (RSV) is a formidable respiratory pathogen that particularly affects infants and children. RSV presents with diverse clinical severity, most often causing mild upper airway symptoms but sometimes progressing to severe and potentially fatal lower respir...

Seismic Constraints of the 23 November 2025 Hayli Gubbi Eruption Sequence in Afar, Ethiopia

Abstract On 23 November 2025, the Hayli Gubbi volcano in Afar (Ethiopia) erupted in a massive explosion. We present the first seismic characterization using data from 13 regional seismological stations. Seismograms reveal signals consisting of a minute‐long precursor, a main erup...

Environmentally induced dynamics between intraindividual variation and trait means across vegetative, phenological, and floral traits

PREMISE: Intraindividual variation in reiterated structures (e.g., leaves) represents an important dimension of phenotypic variation that contributes to functional diversity and the dynamics of ecological communities. It can be expressed differently across plant traits, but how e...

An analysis of the socially differentiated associations between digital skills and starting an apprenticeship in Germany

Earlier research documented that youth from lower SES have lower level of digital skills compared to those from high SES. However, we still lack evidence regarding the benefits of digital skills for the transition to apprenticeship for youth with different social backgrounds. We...

“We could do more”: exploring violance prevention measures in German outpatient primary care — a qualitative study

Healthcare workers in general practice are exposed to verbal and physical violence from patients and accompanying persons. While research has predominantly focused on hospital settings, evidence on violence prevention in primary care remains limited. General practice staff often...

Effects of remote ischemic preconditioning on intestinal oxygenation, microcirculation, and mitochondrial respiration within the second window of organ protection in a rodent hemorrhagic shock model

Abstract Background In the setting of high-risk surgery, preventive strategies to maintain intestinal tissue integrity are of particular importance, as no bridging organ replacement therapy exists. Remote ischemic preconditioning (RIPC) has been reported to attenuate organ injury...

The Past, Present, and Future of Online Biodiversity Knowledge Systems

In recent decades, the availability and accessibility of biodiversity data and the profusion of portals, tools, and platforms through which to utilize them have increased rapidly. This reflects the extensive variety of challenges biodiversity data are being used to address and th...

Accelerating Translation of NK Cell Therapies to the Clinic: A European Perspective

Adoptive immunotherapies have emerged as a promising strategy in the treatment of hematological malignancies. To date, seven chimeric antigen receptor (CAR)-T cell products have obtained market authorization in Europe for B-cell malignancies, where they have revolutionized treatm...

Reconceptualizing the ethics of diagnosis: a Foucauldian framework

Abstract Background Traditional approaches in medical ethics have primarily focused on the consequences of diagnoses, emphasizing their impact on patients’ lives, treatment options, and social perception. While this perspective remains indispensable, it is limited in its consider...

Legal Struggles Between Managerialism and Authoritarianism: Contesting European Supply Chain Regulation

Abstract Legal struggles unfold when conflicts enter the legal arena and are processed within the framework of the legal form. Traditionally, such battles require a framework in which the pillars of the rule of law guarantee the interpretation and implementation of laws enacted t...

Small molecule inhibitor of orphan GPCR dimerization improves host defense and blood pressure control in mice

Orphan GPCRs of the GPRC5 family regulate macrophage activity and vascular contractility by dimerizing with other GPCRs, but pharmacological modulation of this process has not been explored. We previously identified the dimerization interface of receptor GPRC5B and show here that...

Comparisons of Novel Risk Stratification Models to the Current cT1a/b Staging in Incidental Prostate Cancer

OBJECTIVE: Incidental prostate cancer (PCa) patients are currently stratified to either cT1a vs. cT1b stage, depending on tumor volume (< 5% vs. > 5%) in the resected tissue. We tested for other models that could improve cancer-specific survival (CSS) predictions. METHODS: Incide...

Parkinsonian gait improvement through vibratory stride parameter feedback

Abstract Background Hypokinetic gait increases morbidity and mortality of persons with Parkinson’s disease and constitutes a major target symptom for therapy. Feedback on gait quality, e.g. by a physiotherapist, improves stride length and reduces shuffling. Wearable devices measu...