Goethe University Frankfurt

Who supports transformative parking policies? Insights from urban population segments

Abstract Transformative parking policies aim to address transport and land-use issues in urban neighbourhoods, yet concerns over public acceptability often limit their implementation. To identify barriers and entry points for implementation, this study examines who supports trans...

Complete genome sequence of Thermincola carboxydiphila DSM 17129 T isolated from a hot spring of the Lake Baikal area

ABSTRACT We report on the complete genome sequence of the carboxydotrophic hydrogenogenic, thermophilic, and alkalitolerant acetogen Thermincola carboxydiphila (DSM 17129 T ). The genome harbors a circular chromosome with a size of 3.519 Mbp and a GC content of 45.6%. The genome...

Molecular mechanism of calcium inhibition in viral channelrhodopsins

Abstract Viral channelrhodopsins (VCR1s) are giant-virus-encoded light-gated channels permeable to monovalent and divalent cations, including Na + and Ca 2+ ions, and inhibited by millimolar Ca 2+ concentrations. Here, we combine X-ray crystallography, time-resolved UV-vis spectr...

Security provider meets security seekers: Explaining the support for China’s Global Security Initiative through role alignment

Abstract China’s Global Security Initiative (GSI), launched in 2022, has rapidly turned into a flagship programme through which Beijing seeks to present itself as an international security actor and foster strategic alignment both within and beyond its immediate neighbourhood. Wh...

Exploring spatial heterogeneity of PD-L1 and c-MET expression in oral squamous cell carcinoma

Abstract Background PD-L1 expression is an established predictive biomarker for immune checkpoint inhibitor therapy in recurrent or metastatic head and neck squamous cell carcinoma (HNSCC), including oral squamous cell carcinoma (OSCC). However, the spatial heterogeneity of PD-L1...

Mediatised Agricultural TechnoEnvironments in Indonesia. Reimagining Embodied Knowledge and Practice in Technological Environments

Abstract Indonesia’s response to the digital era entails both opportunities and challenges and shows how the state and civil society alike navigate through policies and implementations. Mediatisation is affecting more and more areas of life, and Indonesian netizens negotiate and...

SEMi-Complete by Design: A Monte Carlo simulation to assess Measurement Invariance in Moderated Nonlinear Factor Analysis and SEM-Trees

Ensuring the validity of psychological assessments is crucial, yet differential itemfunctioning (DIF) can threaten measurement invariance (MI) (Bauer, Belzak, and Cole2020). Recent calls for improved DIF detection methods emphasize the need for moreadvanced statistical approaches...

Annual Research Review: Sex differences in conduct disorder – revisiting existing evidence and exploring future directions

Conduct disorder (CD) is a common psychiatric disorder in youth, characterized by severe and recurrent aggressive and antisocial behaviors and associated with substantial healthcare and societal costs. Rates of CD increase during adolescence in both sexes, with the male‐to‐female...

Parvovirus B19 infections in paediatric sickle cell disease patients: Genotype and hydroxyurea treatment influence disease severity

Summary In patients with sickle cell disease (SCD), parvovirus B19 infection (B19V) leads to acute anaemia (aplastic crisis), but may also be associated with other serious complications. We retrospectively analysed clinical data from paediatric SCD patients with B19V infections b...

Tearing Down Scientific Boundaries: Frontiers in Medicinal Chemistry 2026

The Frontiers in Medicinal Chemistry (FiMC) was held in Münster from March 24 th to 27 th as the largest international Medicinal Chemistry conference in Germany. Welcoming more than 240 participants from around 20 countries, it was a vibrant conference, celebrating the community...

Enhanced coupling efficiency in geometric terahertz rectennas based on scalable CVD graphene

Ubiquitous electromagnetic radiation from wireless communication networks is an untapped energy source for low-power devices. Passive rectennas (a combination of a rectifier and an antenna) can harvest this energy to power devices and systems, such as autonomous sensors. Rectenna...

Discovery of an intrinsic non-Hermitian phase transition in a bulk condensed-matter system

Across regular phase transitions, systems remain in thermal equilibrium. However, when a system is driven far from equilibrium, non-Hermitian phase transitions may arise where the dynamical behavior—rather than steady properties—undergoes a qualitative change at a critical, so-ca...

36Cl concentrations from polar ice cores set new constraints on the Carrington event.

The Carrington event of 1859 CE is considered one of the largest geomagnetic storms of the observational era and often used as a benchmark for a worst-case scenario. Yet, there exists no robust evidence of an associated solar energetic particle (SEP) event of a significant magnit...

Anatomy-based vs. logarithmic standard frequency allocation in cochlear implants: A comparative study on speech intelligibility and sound quality

The here presented prospective, randomized, single-blinded crossover study investigated the effects of anatomy-based versus standard logarithmic frequency allocation on speech intelligibility and sound quality in 77 adult first-time cochlear implant (CI) recipients. Cochlear impl...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

Prognostic Role of Adverse Events in a Worldwide Population of Patients with Biliary Tract Cancer Treated with Chemo-Immunotherapy

Background: Biliary tract cancers (BTCs) are aggressive malignancies with limited treatment options. The addition of durvalumab or pembrolizumab to cisplatin–gemcitabine improves overall survival (OS), but validated biomarkers of benefit remain limited. Immune-mediated adverse ev...

The added value of Med-CORDEX coupled high-resolution regional climate models in representing sea surface temperature and marine heatwaves in the Mediterranean Sea

Marine heatwaves (MHWs) pose significant threats to Mediterranean marine ecosystems and coastal economies, with frequency and severity projected to increase under future climate change. While Med-CORDEX fully-coupled Regional Climate System Models (RCSMs) offer enhanced resolutio...

Molecular epidemiology and management of non-tuberculous mycobacteria isolated from patients in Ukraine, 2022–2024

Non-tuberculous mycobacteria (NTM) are increasingly recognized worldwide as significant causes of chronic pulmonary disease, particularly among individuals with underlying structural lung disorders or immunosuppression. However, data on the epidemiology and clinical management of...

Sleep duration links to biological aging clocks: when sleep gets tough, aging gets going

In a recent large-scale study of biological ageing clocks published in Nature , the MULTI Consortium now shows sleep, often treated as a lifestyle habit, is a measurable sign of temporal biology. Their work suggests that deviations from optimal sleep duration are associated with...

Results from the Pan-European CIEMAR study: Local Tumour Control After Microwave Ablation of Colorectal Liver Metastases and Exploratory Associations with Ablation Margins and Confirmation Software

Abstract Purpose The CIRSE Emprint Microwave Ablation (MWA) Registry (CIEMAR) was designed to evaluate real-world effectiveness of MWA for colorectal liver metastases (CRLM). This analysis reports on local tumour control and includes post-hoc analyses of ablation margin size and...