Goethe University Frankfurt

Neuropsychobiological transdiagnostic risk mechanisms for aggression in mental disorders across the life span

Abstract Background Aggression in mental disorders (AMD) is a prevalent symptom, poses difficulties to the clinical setting and has far-reaching societal implications. The biological basis of different manifestations, developmental courses, and disease-specific mechanisms remains...

Multimodal Hyperspectral Imaging Unveils Pigment Rearrangement in the Diatom Cyclotella meneghiniana under Changing Physicochemical Conditions

Abstract Revealing the spatial organization and stress-induced rearrangements of the photosynthetic machinery in thylakoids of diatoms is crucial for understanding their metabolic responses and/or adaptation. Using a multimodal framework that combines coherent anti-Stokes Raman s...

Testing machine-learned distributions against Monte Carlo data for the QCD chiral phase transition

A bstract We demonstrate that conditional Masked Autoregressive Flows constitute a flexible interpolation tool for lattice QCD observables, conditioned on bare lattice parameters. As a benchmark, we use the chiral phase structure of QCD with five degenerate light quark flavours,...

Targeting biglycan–TLR2/TLR4 interaction with synthetic peptides mitigates inflammation and ameliorates renal function in ischemia–reperfusion injury

Renal ischemia–reperfusion injury (IRI), characterized by enhanced inflammation, is a leading cause of acute kidney injury (AKI) with limited treatments beyond supportive dialysis. Biglycan through toll-like receptors (TLR)2/TLR4 signaling aggravates tissue damage in acute renal...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Long-Term Outcomes of Interventional Treatments for Lung Cancer Liver Metastases: Transarterial Chemoembolization and Microwave Ablation

Purpose: The aim of this study was to evaluate the long-term results of transarterial chemoembolization (TACE) and microwave ablation (MWA) as locoregional interventional treatments for lung cancer liver metastases (LCLM) in different protocols and settings. Material and Methods:...

Measurements of the production of W$$^{\pm }$$ and Z$$^0$$ bosons in pp collisions at $$\sqrt{s} = 13$$ TeV

Abstract Measurements of the production of the W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons at midrapidity in pp collisions at $$\sqrt{s} = 13$$ s = 13 TeV with ALICE at the Large Hadron Collider (LHC) are presented. The W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons are detected via their (di)e...

Structure-function coupling reveals hemisphere-specific network reorganization after stroke

MRI is an excellent tool for monitoring functional and structural network reorganization after brain injury and may provide biomarkers for treatment stratification and novel neuromodulatory interventions. In ischemic stroke, functional network changes, particularly within the con...

A Statistical Perspective on Transformers for Small Longitudinal Cohort Data

ABSTRACT Modeling of longitudinal cohort data typically involves complex temporal dependencies between multiple variables. There, the transformer architecture, which has been highly successful in language and vision applications, allows us to account for the fact that the most re...

A random forest isoscape model of bioavailable Sr for South America: a focus on southern Brazil

In recent years, advances in machine learning have greatly improved the generation of maps showing the geographic distribution of isotope ratios (isoscapes), which have become essential tools for environmental, mobility and provenance studies in both modern and archaeological con...

The Cold-Air Outbreaks in the Marine Boundary Layer Experiment model-observation intercomparison project (COMBLE-MIP) – Part 1: Model specification, observational constraints, and preliminary findings

Models struggle to represent the coupled microphysical, turbulent and radiative processes within widespread, long-lived marine cold-air outbreak (CAO) cloud fields, contributing to forecast and climate biases. Here we combine ground-based and satellite measurements to initialize...

The Use of a Human Acellular Dermal Matrix (hADM) Transplant in Stage 4 Osteochondrosis Dissecans: A Retrospective Proof of Concept

Background: Osteochondral lesions (OD) of the talus represent a significant clinical challenge, particularly in advanced-stage cases requiring osteotomy access and cancellous bone grafting. Human acellular dermal matrix (hADM) has demonstrated promising biological properties—incl...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Small Molecule Modulation of TERRA RNA Quadruplex Reprograms ALT‐Telomere Maintenance

ABSTRACT Telomeric repeat–containing RNA (TERRA) plays a central role in telomere maintenance in telomerase‐negative cancers that employ the alternative lengthening of telomeres (ALT) pathway; however, its RNA G‐quadruplex (rG4) structures remain underexplored as chemical targets...

Long‐term stability and reproducibility of frozen plasma control samples for hepatitis B virus, hepatitis C virus, and human immunodeficiency virus by quantitative PCR : Implications for retrospective testing in hemovigilance

Abstract Objective Data on the long‐term stability and reproducibility of nucleic acid amplification testing (NAT) results in frozen stored positive samples (≤−20°C) remain limited. This study evaluated the long‐term performance of frozen virus‐positive samples in quantitative PC...

Changes-in-Changes for Ordered Choice Models with Underreporting

We develop a Difference-in-Differences framework for discrete, ordered outcomes subject to underreporting. Such outcomes commonly arise in self-reported surveys on socially undesirable or stigmatized behaviors, where respondents may conceal their true behavior. For a discrete Cha...

Democratisation and carbon emissions: evidence from political regime transitions

Abstract This paper examines whether democratisation has a robust average effect on aggregate territorial carbon emissions. Using a country-year dataset covering 183 countries over 1960–2010, we compare countries that experience democratic transitions or reversals with those that...

Sodium hexametaphosphate and ultrasonication − Comparing chemical and physical dispersion methods for soil organic matter fractionation

Soil organic matter (SOM) fractionation into particulate organic matter (POM) and mineral-associated organic matter (MAOM) is widely applied to investigate soil organic carbon (SOC) stabilization and turnover, yet the choice of dispersion method strongly influences fractionation...

Who supports transformative parking policies? Insights from urban population segments

Abstract Transformative parking policies aim to address transport and land-use issues in urban neighbourhoods, yet concerns over public acceptability often limit their implementation. To identify barriers and entry points for implementation, this study examines who supports trans...

Complete genome sequence of Thermincola carboxydiphila DSM 17129 T isolated from a hot spring of the Lake Baikal area

ABSTRACT We report on the complete genome sequence of the carboxydotrophic hydrogenogenic, thermophilic, and alkalitolerant acetogen Thermincola carboxydiphila (DSM 17129 T ). The genome harbors a circular chromosome with a size of 3.519 Mbp and a GC content of 45.6%. The genome...