Goethe University Frankfurt

Effects of remote ischemic preconditioning on intestinal oxygenation, microcirculation, and mitochondrial respiration within the second window of organ protection in a rodent hemorrhagic shock model

Abstract Background In the setting of high-risk surgery, preventive strategies to maintain intestinal tissue integrity are of particular importance, as no bridging organ replacement therapy exists. Remote ischemic preconditioning (RIPC) has been reported to attenuate organ injury...

The Past, Present, and Future of Online Biodiversity Knowledge Systems

In recent decades, the availability and accessibility of biodiversity data and the profusion of portals, tools, and platforms through which to utilize them have increased rapidly. This reflects the extensive variety of challenges biodiversity data are being used to address and th...

Accelerating Translation of NK Cell Therapies to the Clinic: A European Perspective

Adoptive immunotherapies have emerged as a promising strategy in the treatment of hematological malignancies. To date, seven chimeric antigen receptor (CAR)-T cell products have obtained market authorization in Europe for B-cell malignancies, where they have revolutionized treatm...

Reconceptualizing the ethics of diagnosis: a Foucauldian framework

Abstract Background Traditional approaches in medical ethics have primarily focused on the consequences of diagnoses, emphasizing their impact on patients’ lives, treatment options, and social perception. While this perspective remains indispensable, it is limited in its consider...

Comparisons of Novel Risk Stratification Models to the Current cT1a/b Staging in Incidental Prostate Cancer

OBJECTIVE: Incidental prostate cancer (PCa) patients are currently stratified to either cT1a vs. cT1b stage, depending on tumor volume (< 5% vs. > 5%) in the resected tissue. We tested for other models that could improve cancer-specific survival (CSS) predictions. METHODS: Incide...

Legal Struggles Between Managerialism and Authoritarianism: Contesting European Supply Chain Regulation

Abstract Legal struggles unfold when conflicts enter the legal arena and are processed within the framework of the legal form. Traditionally, such battles require a framework in which the pillars of the rule of law guarantee the interpretation and implementation of laws enacted t...

Small molecule inhibitor of orphan GPCR dimerization improves host defense and blood pressure control in mice

Orphan GPCRs of the GPRC5 family regulate macrophage activity and vascular contractility by dimerizing with other GPCRs, but pharmacological modulation of this process has not been explored. We previously identified the dimerization interface of receptor GPRC5B and show here that...

Parkinsonian gait improvement through vibratory stride parameter feedback

Abstract Background Hypokinetic gait increases morbidity and mortality of persons with Parkinson’s disease and constitutes a major target symptom for therapy. Feedback on gait quality, e.g. by a physiotherapist, improves stride length and reduces shuffling. Wearable devices measu...