Friedrich-Alexander-Universität Erlangen-Nürnberg

Brugada Syndrome in the Pediatric Population: Diagnostic Challenges and Clinical Outcome—Results of the German Multicenter Study COGIA

ABSTRACT Introduction Diagnosis and treatment of children and adolescents with suspected Brugada syndrome (BrS) is challenging. Aim of the study was to evaluate the applicability of current diagnostic criteria for pediatric patients with suspected BrS in the German multicenter st...

Strategic embedding? Regional governance and resilience in the beverage sector

Abstract The disruptions following the COVID-19 pandemic revealed many vulnerabilities of the fragmented global economy. Simultaneously, the pandemic disrupted regional production, hindering regional value creation. In Germany, the Bavarian beer sector received high prominence du...

Time-resolved energy-share reconstruction of individual glycolytic flux kinetics reveals duration-dependent bias in elite sprint cycling

Abstract Background Maximal lactate accumulation rate (vLamax) is commonly used as a surrogate of anaerobic glycolytic power. Conventional protocols calculate vLamax as a mean rate over a fixed sprint window after subtracting an alactic phase, even though glycolytic flux rises, p...

High-resolution peripheral quantitative computed tomography imaging and bone biomarker characteristics of patients with ischemic stroke or transient ischemic attack—baseline analysis of the Post-stroke Osteopathy study

Stroke or transient ischemic attack (TIA) leads to unfavorable structural changes in the bones. The underlying pathophysiological process is unclear. We provide a detailed characterization of the structural and biochemical properties of bone in a stroke/TIA cohort. Our findings l...

Efficacy and safety of SP16 in preventing acute kidney injury in at-risk subjects with chronic kidney disease undergoing elective cardiac surgery using the heart–lung-machine (EASE-AKI): study protocol for a prospective, randomised, double-blind, placebo-controlled clinical trial

Abstract Background Cardiac surgery using cardiopulmonary bypass uses controlled hypoperfusion which leads to relative organ damage. Acute kidney injury is the most frequent and most important organ failure, in particular in patients with chronic kidney disease. To date, there ar...

Iron-catalyzed [1+1+1] cyclopropanation by sequential coupling of an ester to two carbenes

Traditional precious metal catalysis benefits from well-characterized inner-sphere elementary steps in which a single complex binds and unites substrates at the metal center. By contrast, base metal catalysts have recently demonstrated competence in cross-coupling transformations...

Tissue and Cerebral Biofluid Remodelling of tRNA-Derived Small RNA Signatures in Experimental and Human Epilepsy

Small noncoding RNAs are increasingly recognized as important regulators of gene expression in brain diseases including epilepsy. tRNA-derived small RNAs (tsRNAs) including tRNA fragments (tRFs) and tRNA halves (tiRNAs) are emerging as stable and regulated RNA species which respo...

Effects of hyperbaric oxygen therapy on bone, muscle, cartilage, tendon and ligaments in animal studies: a systematic review

Hyperbaric oxygen therapy (HBOT) has been investigated for its potential to enhance tissue healing because of its capacity to increase oxygen tension in ischemic and hypoxic tissues. Numerous preclinical studies have explored its role in the repair and regeneration of different m...

A Cournot–Nash model for a coupled hydrogen and electricity market

Abstract We present a novel model of a coupled hydrogen and electricity market on the intraday time scale, where hydrogen gas is used as a storage device for the electric grid. Electricity is produced by renewable energy sources or by extracting hydrogen from a pipeline that is s...

Transient Laser‐Induced Periodic Surface Structures Revealed by Time‐Resolved EUV Diffuse Scattering

ABSTRACT The formation of permanent laser‐induced periodic surface structures (LIPSS) on solid surfaces under impulsive laser irradiation above the damage threshold has been the subject of extensive research. Here, we report the formation of transient quasi‐periodic surface modul...

Cold atmospheric plasma affects metabolic processes in malignant melanoma

BACKGROUND: Partially ionized gas, also known as cold atmospheric plasma (CAP), is reported to have anti-tumor specific properties via reactive oxygen and nitrogen species (RONS) in different tumor entities. Many CAP effects have already been studied, but the exact influence on m...

Pediatric Clostridium septicum infections: a systematic review and case-based perspective

Abstract Context Pediatric Clostridium septicum infections are extremely rare but often fulminant and rapidly progressive. They may manifest as clostridial myonecrosis, sepsis, or with gastrointestinal involvement. Systematic data on presentation, management, and outcomes remain...

The interplay of influencing factors in physical activity promotion for older men: insights through the capability approach

Abstract Background The capability approach has gained increasing attention in the context of health and physical activity promotion due to its focus on individuals’ freedoms to achieve desired outcomes. Its empirical application remains limited, particularly among older men, a g...

Probabilistic robustness for compressor controls in transient pipeline networks

Abstract Uncertainty plays a crucial role in modeling and optimization of complex systems across various applications. In this paper, uncertain gas transport through pipeline networks is considered and a novel strategy to measure the robustness of deterministically computed compr...

A cardiovascular-motor axis framework for perfusion-mediated motor impairment

Cardiovascular disease is the leading cause of death worldwide, and among survivors of heart failure, peripheral arterial disease, valvular disease, and atrial fibrillation many develop motor impairment: weakness, slow gait, sarcopenia, frailty. These deficits are usually attribu...

Pharmacokinetics of IL-23p19 Inhibitors: A Systematic Review Across Immune-Mediated Inflammatory Diseases

Interleukin (IL)-23p19 inhibitors are increasingly used in immune-mediated inflammatory diseases (IMIDs), particularly inflammatory bowel disease (IBD). Almost half of patients show inadequate response, partly due to pharmacokinetic (PK) variability. However, a comprehensive over...

Reduced extinction risk for autotrophs in the open ocean

Abstract The marine plankton record offers a unique archive of deep-time ecological and evolutionary dynamics in the open ocean. With distinct biomineral compositions, trophic modes and other diverse ecological and geographic preferences, fossilized marine unicellular plankton gr...

BAGLS-VF: a comprehensive dataset for glottal area and vocal fold segmentations

Abstract Objective Datasets for automatic analysis of laryngeal endoscopic images are scarce, particularly those providing detailed anatomical annotations beyond the glottal area. The BAGLS dataset previously introduced a large collection of laryngoscopic images with expert annot...

Navigating Classical and Nonclassical Realms of Nucleation and Crystallization

Our understanding of the formation and growth of solids from solution has shaped science for centuries. The classical nucleation and crystal growth theories provided a foundational framework, despite their necessary simplifications. Recent nonclassical concepts have challenged th...

Towards a Higher-Order Bialgebraic Denotational Semantics

The bialgebraic abstract GSOS framework by Turi and Plotkin provides an elegant categorical approach to modelling the operational and denotational semantics of programming and process languages. In abstract GSOS, bisimilarity is always a congruence, and it coincides with denotati...