Friedrich-Alexander-Universität Erlangen-Nürnberg

Pharmacokinetics of IL-23p19 Inhibitors: A Systematic Review Across Immune-Mediated Inflammatory Diseases

Interleukin (IL)-23p19 inhibitors are increasingly used in immune-mediated inflammatory diseases (IMIDs), particularly inflammatory bowel disease (IBD). Almost half of patients show inadequate response, partly due to pharmacokinetic (PK) variability. However, a comprehensive over...

The interplay of influencing factors in physical activity promotion for older men: insights through the capability approach

Abstract Background The capability approach has gained increasing attention in the context of health and physical activity promotion due to its focus on individuals’ freedoms to achieve desired outcomes. Its empirical application remains limited, particularly among older men, a g...

Pediatric Clostridium septicum infections: a systematic review and case-based perspective

Abstract Context Pediatric Clostridium septicum infections are extremely rare but often fulminant and rapidly progressive. They may manifest as clostridial myonecrosis, sepsis, or with gastrointestinal involvement. Systematic data on presentation, management, and outcomes remain...

A cardiovascular-motor axis framework for perfusion-mediated motor impairment

Cardiovascular disease is the leading cause of death worldwide, and among survivors of heart failure, peripheral arterial disease, valvular disease, and atrial fibrillation many develop motor impairment: weakness, slow gait, sarcopenia, frailty. These deficits are usually attribu...

Probabilistic robustness for compressor controls in transient pipeline networks

Abstract Uncertainty plays a crucial role in modeling and optimization of complex systems across various applications. In this paper, uncertain gas transport through pipeline networks is considered and a novel strategy to measure the robustness of deterministically computed compr...

Cold atmospheric plasma affects metabolic processes in malignant melanoma

BACKGROUND: Partially ionized gas, also known as cold atmospheric plasma (CAP), is reported to have anti-tumor specific properties via reactive oxygen and nitrogen species (RONS) in different tumor entities. Many CAP effects have already been studied, but the exact influence on m...

Reduced extinction risk for autotrophs in the open ocean

Abstract The marine plankton record offers a unique archive of deep-time ecological and evolutionary dynamics in the open ocean. With distinct biomineral compositions, trophic modes and other diverse ecological and geographic preferences, fossilized marine unicellular plankton gr...

Knowledge and Risk Perception Regarding Skin Cancer in Immunosuppressed Patients: A Systematic Review and Meta-Analysis

Immunosuppressed patients have a substantially increased risk for developing skin cancer. Therefore, it is mandatory that such patients are adequately informed and aware of skin cancer and their increased risk to modify their behavior. Numerous studies have evaluated the topic, b...

Towards a Higher-Order Bialgebraic Denotational Semantics

The bialgebraic abstract GSOS framework by Turi and Plotkin provides an elegant categorical approach to modelling the operational and denotational semantics of programming and process languages. In abstract GSOS, bisimilarity is always a congruence, and it coincides with denotati...

Navigating Classical and Nonclassical Realms of Nucleation and Crystallization

Our understanding of the formation and growth of solids from solution has shaped science for centuries. The classical nucleation and crystal growth theories provided a foundational framework, despite their necessary simplifications. Recent nonclassical concepts have challenged th...

Assessing climate change-related health hazards: An interactive tool for regional risk analysis in Germany

An interactive online health risk assessment has been created to visualize the health risks associated with climate change at the district level (NUTS3) across Germany. The tool provides a comprehensive assessment by depicting both the current risk patterns and projected conditio...

BAGLS-VF: a comprehensive dataset for glottal area and vocal fold segmentations

Abstract Objective Datasets for automatic analysis of laryngeal endoscopic images are scarce, particularly those providing detailed anatomical annotations beyond the glottal area. The BAGLS dataset previously introduced a large collection of laryngoscopic images with expert annot...

Vibrational power spectra as a tool to benchmark universal machine-learning interatomic potentials for molecular systems: the OMOL-1k-MD data set

Abstract We present OMOL-1k-MD, a new dataset for the benchmark and training of universal machine-learning interatomic potentials (uMLIPs). It contains three independent ab initio molecular dynamics (AIMD) trajectories of 10 ps each for 1000 arbitrarily chosen neutral closed shel...

Raw data to "Unconventional entanglement scaling and quantum criticality in the long-range spin-one Heisenberg chain with single-ion anisotropy"

This directory contains the data used to generate the numerical results in the work "Unconventional entanglement scaling and quantum criticality in the long-range spin-one Heisenberg chain with single-ion anisotropy [1]". [1]: P. Adelhardt, S. R. Muleady, K. P. Schmidt, and A. V....

Virtual worlds and mental health: A scoping review

<title>Abstract</title> The constant increase in the use of virtual worlds in recent decades has raised concerns about their potential effects on users’ mental health. However, the great heterogeneity of the scientific literature on this topic makes it difficult to identify exist...

First-line immune checkpoint inhibitors versus chemotherapy in delaying quality of life deterioration in advanced NSCLC: a systematic review and meta-analysis

Backgroud: Immune checkpoint inhibitors (ICIs) have transformed first-line treatment for advanced non–small-cell lung cancer (aNSCLC). While overall survival(OS) remains the primary endpoint, health-related quality of life (HRQoL) is a key patient-centered outcome. Time to deteri...

GeoHash3D: Robust and Efficient 6-DoF Pose Estimation from 3D Marker Sets

Accurately measuring the six degrees of freedom (6-DoF) pose of a sample is a critical prerequisite for applications in robotic sample handling, optical metrology, and industrial quality control. Our pose estimation problem requires matching a small, partial observation of 4–20 d...

Long-Lived Interfacial Charge Separation in PyrenylimidazolylPhthalocyanine@Transition Metal Dichalchogenide Heterostructures

Abstract Pyrenylimidazolyl-functionalized free-base phthalocyanines (H2Pc) and their zinc complexes (ZnPc) constitute multifunctional building blocks for realizing heterostructures with liquid phase exfoliated transition-metal dichalcogenides (LPE-TMDs). Here, we report the synth...

Adapted foundation models for breast MRI triaging in contrast-enhanced and non-contrast-enhanced protocols

Abstract Objectives To evaluate a DINOv2-based medical slice transformer (MST) for triaging abbreviated breast MRI by ruling out examinations with suspicious findings that are immediately actionable (Breast Imaging Reporting and Data System [BI-RADS] ≥ 4) across contrast-enhanced...

Spot melting in electron beam powder bed fusion: influence of the melt pool shape on microstructure and texture

Abstract Reliable microstructure control remains a major challenge in electron beam powder bed fusion, particularly for Ni-based superalloys such as IN718, where large columnar grains with a strong $$\langle 100\rangle $$ texture cause highly anisotropic behavior, often limiting...