Friedrich-Alexander-Universität Erlangen-Nürnberg

Air- and Thermally Stable Organometallic Fe(VI) Nitrides Enabled by a Tripodal Mesoionic Carbene Ligand: Access to a Water-Coordinated Fe(VI) Nitrido Complex

Abstract A tripodal mesoionic carbene (MIC) ligand, tris-[4-(1-mesityl-3-methyl-1,2,3-triazol-5-ylidene)methyl]amine (TAMNMes), enables the synthesis and isolation of a family of exceptionally robust organometallic Fe(VI) nitrido complexes. One-electron oxidation of the correspon...

Navigating the paradox: Empowerment and power dynamics in international social entrepreneurship

Social entrepreneurship (SE) often seeks to empower marginalized beneficiaries by reshaping unequal power relations and promoting more enduring forms of social change. Yet efforts to empower others inherently involve the exercise of power and may therefore reproduce the very asym...

Drug-Dependent Disruption of Amyloid Nanofibril-Mediated Wrinkling in Supraparticle Assemblies

Supraparticles (SPs) are secondary particles formed through nanoparticle self-assembly with porous architectures and bioinspired structural features suitable for drug delivery applications. Although binder-mediated structural control influences SP assembly, how different loaded d...

Slice‐Wise Quality Assessment of High b Value Breast DWI via Deep Learning‐Based Artifact Detection

BACKGROUND: Diffusion-weighted imaging (DWI) can support lesion detection and characterization in breast MRI. Therefore, DWI is increasingly being incorporated into breast MRI protocols to address some of the shortcomings of routine clinical breast MRI. However, especially high b...

Development and Nationwide Multicentre Evaluation of Guideline-Grounded Large Language Model Chatbots to Support Patient Self-Management and Education in Rheumatology

Patients with rheumatic diseases have persistent information needs that are not fully addressed in routine care. We developed and evaluated guideline-grounded, large language model (LLM) chatbots to support patient self-management and education in rheumatology.Ten disease-specifi...

Should I drink water or wine? Impacts of online nutritional counseling on the alcohol consumption of elderly individuals with mild cognitive impairment

Abstract Background People with mild cognitive impairment (MCI) have an increased health risk when they consume alcohol in comparison with people without cognitive impairment. Excessive alcohol consumption is an established modifiable risk factor that contributes to the risk of d...

Accurate electron affinities from anion HOMO energies within the self-consistent random phase approximation

Density functional calculations of small anions using the self-consistent random phase approximation (scRPA) optimized effective potential method are presented. scRPA calculations provide bound anions with the negative of the highest occupied molecular orbital (HOMO) energy close...

A microbial therapy-mimicry assay shows how spatial resource dynamics control resistance escape

Abstract The evolution of therapy resistance in structured populations such as biofilms and solid tumours is shaped by emergent spatial organization, with profound consequences for evolution-based therapies. However, how treatment reshapes these patterns remains poorly understood...

Crystallization in the Winterbottom Shape and Sharp Fluctuation Laws

Abstract We address finite crystallization in two dimensions in the presence of a flat crystalline substrate. Particles interact through short-range two- and three-body potentials favoring local square-lattice arrangements. An additional interaction term of relative strength $$\b...

Rheumatologists’ expectations and perceptions of T-cell redirecting therapies: results from a cross-sectional survey

Abstract T-cell redirecting therapies (TCRTs), including Chimeric antigen receptor (CAR)-T cells and T-cell engagers (TCEs), are emerging as transformative treatments for autoimmune diseases. However, clinical application is currently restricted to specialized centers, leaving mo...

The orofacial cleft risk gene IRF6 is a target gene of SOX9 in cranial neural crest cells

Abstract Orofacial clefts represent the most prevalent congenital anomalies affecting the craniofacial region. They can be evoked by a disturbed development of either oral epithelium or cranial neural crest-derived mesenchyme, or by disruptions of their interplay. IRF6 is a well-...

Chemically Induced Spin-Crossover in an Iron(II) Bis(Pyrazol-1-yl)pyridine-Based Complex in Solution

Abstract Bis(pyrazol-1-yl)pyridine (1-BPP)-based iron(II) spin-crossover complexes have been widely investigated in the solid state. However, the application of such systems in the solution phase remains challenging. Here, we report a series of boronic acid-featured 1-BPP iron(II...

Actin conformation dynamics precede force generation in cytotoxic T lymphocytes

Abstract Cytotoxic T lymphocytes (CTLs) are cells of the adaptive immune system that are able to recognise and kill cancerous or virally infected target cells. The biochemical basis of CTL-mediated killing has been examined in great detail. Recent work has underscored the importa...

Ligand-Shell Softness Directs Symmetry Transitions in Nanotripod Superstructures

Abstract Low-symmetry, nonconvex nanocrystals offer access to superlattices with structural motifs that are difficult to realize from convex building blocks. Here, we show that polymer-grafted Gd2O3 nanotripods assemble into compact achiral and open chiral nanoporous superstructu...

Patient‐reported outcomes and medication errors during oral antitumour therapy in paediatrics: Results from the youngAMBORA care programme

AIM: Increasing use of oral antitumour therapeutics (OAT) in paediatrics is associated with numerous advantages, but also with error-prone aspects. Based on the randomized AMBORA trial including adults treated with various OAT, we developed a tailored pharmacological/pharmaceutic...

The indolent nature of gastroblastoma. Report of an illustrative case with 28 years of follow-up showing previously unreported immunohistochemical and molecular features

We report the clinical, morphological, ultrastructural, and molecular features of a gastroblastoma diagnosed in a 27-year-old male describing some unreported findings that can help to better understand this very rare tumor. The clinical course lasting 28 years confirms the indole...

Local electricity price effects of Bitcoin mining in renewable-rich energy systems

Load-shifting is increasingly important in renewable-rich energy systems. Bitcoin mining is often cited as a large, theoretically flexible load. Despite electricity consumption rivaling medium-sized industrial economies, the energy market behavior and impacts of Bitcoin miners re...

Raman Response of Monolayer Graphene Upon Varying TCNE Adsorption

ABSTRACT Graphene is the prototype two‐dimensional material with an intriguing Dirac‐like electronic dispersion relation. To control graphene's material properties, the non‐covalent adsorption of molecular species remains a promising approach and has been proven to have high pote...

Chronic Kidney Disease‐Associated Pruritus Is Linked to Selective Enrichment of Taurine‐Conjugated Bile Acid Subspecies

ABSTRACT Background Chronic kidney disease‐associated pruritus (CKDaP) is a common and debilitating symptom in patients with advanced renal disease. The underlying pathophysiology of CKDaP remains poorly understood, but dysregulation of bile acid metabolism has been suggested as...

Optimal Decay Rate for a Degenerate Hyperbolic-Parabolic Coupled System

Abstract. We investigate the long-time asymptotic behavior of a one-dimensional degenerate hyperbolic-parabolic coupled PDE system modeling diffusion-wave interactions with degeneracy at the interface. The system consists of a degenerate heat-wave equation on a finite interval, w...