Friedrich-Alexander-Universität Erlangen-Nürnberg

Immunohistochemical stratification of bladder small cell carcinoma reveals two major phenotypes with distinct therapeutic biomarker profiles

Aims Small cell carcinoma of the bladder (SmCCB) is a rare and aggressive malignancy that remains poorly defined. Using the transcriptional taxonomy established for small cell lung carcinoma (SCLC), we aimed to stratify SmCCB by dominant transcription factors and assess associati...

Efficacy, safety and circulating tumor cell dynamics in patients treated with Eribulin for HER2-negative advanced breast cancer – results from the phase II DETECT IVb trial

Abstract Background Eribulin is a non-taxane microtubule inhibitor that showed survival benefits for pretreated metastatic breast cancer (MBC) patients. Circulating tumor cells (CTCs) are a prognostic marker, but their role in predicting response to specific MBC treatments is les...

Projecting the evolution of the Northern Patagonian Icefield until the year 2200

The Northern Patagonian Icefield (NPI), Chile, is the second-largest ice mass in the Southern Hemisphere outside Antarctica and a major remnant of the Patagonian ice sheet from the Last Glacial Period. It is located in the Southern Andes, which is among the world’s glacierized re...

Three-dimensional analysis of a single-step cylinder wake via stereoscopic particle image velocimetry

The present experimental study investigates the turbulent flow field past a single-step cylinder, characterized by a fixed ratio r between the large diameter D and the small diameter d equal to 2, for multiple values of the Reynolds number: R e D = 3000,5000 , and 7000. To recons...

Divergent c-MYC Expression Patterns in NET and NEC: Insights from a Multicentre Cohort of 1380 Neuroendocrine Neoplasms

Abstract Neuroendocrine neoplasms (NEN) comprise well-differentiated neuroendocrine tumours (NET) and neuroendocrine carcinomas (NEC), whose distinction is clinically critical. Although c-MYC alterations have been implicated in NEC pathogenesis, c-MYC expression across NEC subtyp...

The Python simulations of chemistry framework: 10 years of an open-source quantum chemistry project

Over the past decade, the Python-based Simulations of Chemistry Framework (PySCF) has developed into a widely used open-source platform for electronic-structure theory and quantum chemical method development. This article reviews the major advances since the previous overview in...

Coxiella burnetii establishes a small cell variant (SCV)-like persistent form to survive adverse intracellular conditions

Abstract Coxiella burnetii is an obligate intracellular zoonotic bacterium that causes Q fever. Infections can be either acute or chronic. Of note, chronic Q fever develops months or years after primary infection without clinical symptoms, suggesting bacterial persistence. Yet, i...

Europäische Außenwirtschaftspolitik und die politische Rolle von Unternehmen in der Ära der Geoökonomik

Zusammenfassung Im Kontext geopolitischer Veränderungen wie etwa dem Aufstieg neuer Wirtschaftsmächte, aber auch der US-amerikanischen Abkehr vom liberalen Internationalismus hat sich das Umfeld für die Außenwirtschaftspolitik der Europäischen Union (EU) sowie die Unternehmen in...

Organ and tumor dosimetry of [161Tb]Tb-PSMA-617 radioligand therapy in patients with mCRPC

Abstract Purpose Terbium-161 ( 161 Tb) has emerged as a promising radionuclide for radioligand therapy (RLT) due to its emission of Auger and conversion electrons, which may support therapeutic efficacy through increased local energy deposition. Despite growing research efforts a...

scatterem

scatterem provides two things that share a scattering-matrix substrate. Reconstruction. Direct (single-side-band) ptychography, tilt-corrected dark-field imaging, and their SSNR-weighted Wiener fusion for 4D-STEM data, giving images with both low-frequency phase contrast and high...

Coupling ESPResSo and waLBerla for scalable soft matter simulations with hydrodynamic interactions

Many problems in soft matter research involve particles suspended in a solvent, where hydrodynamic interactions play a crucial role. A well-established simulation approach for such systems combines molecular dynamics for the particles with the lattice-Boltzmann method for the sol...

Collective Bargaining in Germany: Trends and Challenges

ABSTRACT This paper examines the evolution, institutional structure, and challenges of collective bargaining in Germany. Collective bargaining addresses labor market imperfections, redistributes productivity gains, and shapes working conditions. Germany's system centers on indust...

Fully automated pipeline for localization and scoring of rheumatic disease related regions and pathologies in hand MRI

Rheumatic diseases constitute a major cause of chronic pain, functional impairment, and long-term disability worldwide. In rheumatic diseases, reliable assessment of structural damage and inflammatory activity is essential for diagnosis, disease monitoring, and treatment response...

Association between macular edema area on optical coherence tomography and Amsler grid sensitivity in diabetic macular edema: a cross-sectional study

Abstract Background Early detection of diabetic macular edema (DME) is essential to prevent vision loss through timely treatment. Optical coherence tomography (OCT) is the diagnostic gold standard but is not suitable for home monitoring. The Amsler grid represents a simple and in...

Exploring Differential Item Functioning through Machine Learning: A Review of Rasch Trees and Regularized Moderated Rasch Models

Detecting and interpreting differential item functioning (DIF) is critical for ensuring the fairness and validity of measurement instruments. Combinations of psychometric models with data-driven machine learning (ML) approaches have been introduced to facilitate comprehensive DIF...

How reliable is deep inspiration breath hold at CT simulation? Clinical impact of surface-guided breathing training in breast cancer radiotherapy

Abstract Purpose Deep inspiration breath hold (DIBH) is widely used to reduce cardiac dose in left-sided breast radiotherapy. However, the reliability of DIBH at CT simulation, has not been systematically evaluated despite the importance of CT simulation as the basis for treatmen...

Accounting for register-internal variation

Abstract Registers are text varieties associated with situations of use. It has now been documented, however, that texts within registers are not situationally homogeneous — just as they are not linguistically uniform. This led Biber and Egbert (2023) to propose that linguistic v...

The interaction between the ERG responses to sinusoidal modulation and flashes in mice

Abstract Purpose To study the interaction between responses to a sinusoidal modulation and a flash in the mouse ERG. Methods We recorded responses to pulses on a 1 Hz sinewave background (Pulse on Sine Stimuli: PoS) in mice. Flashes were presented at 8 different temporal phases r...

Difficult-to-treat systemic lupus erythematosus: from refractory disease to a multidimensional clinical trajectory

Difficult-to-treat (D2T) systemic lupus erythematosus (SLE) is increasingly recognised in clinical practice but is still conceptually underdeveloped. In contrast to rheumatoid arthritis and psoriatic arthritis, for which formal D2T frameworks have been proposed, SLE still lacks a...

International Society of Urological Pathology Multidisciplinary Expert Consultation Conference on Evaluation of Treatment Effects in Prostate and Bladder Cancer

Treatment effects in the urinary bladder are variable and range from localized post-transurethral resection changes to widespread systemic therapy effects. The International Society of Urological Pathology (ISUP) organized a consensus meeting in Vienna, Austria, in September 2025...