Erasmus University Rotterdam

Redefining liver health: a multidimensional approach to preventing metabolic dysfunction-associated steatohepatitis

Metabolic dysfunction–associated steatohepatitis (MASH) is a rapidly escalating global health challenge driven by complex interactions among metabolic regulation, nutrition, immune signalling, gut microbiota, and environmental exposures. Current disease-centric frameworks priorit...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...

Facilitating advance care planning in oncology: study protocol for the evaluation of a tailored implementation of an advance care planning tool (the INDEED study)

Abstract Background Advance care planning (ACP) improves patient outcomes, but integration of ACP in daily practice for patients with cancer in hospitals remains suboptimal. Systematic implementation of tools to facilitate ACP could overcome the barriers for ACP. In this study we...

From commitment to communication: a roadmap for strategic communication of corporate digital responsibility

Purpose This article introduces a theoretically grounded and practice-oriented roadmap to guide communication professionals in translating corporate digital responsibility (CDR) from organizational commitment into effective communication practice. It seeks to clarify CDR communic...

CPPAtools: a computation toolset for chimera protein prediction and analysis

Genetic or non-genetic frameshifting can increase the production of erroneous proteins, with far-reaching impacts on cellular phenotypes, including cancer. While the presence and impact of genetic alterations cannot be foreseen and are often defined clinically following phenotypi...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...

The Dutch cardiomyopathy registry (DCR); rationale and registry design

BACKGROUND: Cardiomyopathies are important causes of arrhythmias, sudden cardiac death, and heart failure. With accumulating knowledge in clinical, genetic, and molecular phenotyping, the number of distinct disease entities is growing. There is a need for broad, inclusive, high-q...

The Effect of Antenatal Paracetamol on Breathing Effort of Premature Infants at Birth: A Feasibility Trial

Background: Prostaglandin E2 (PGE2) suppresses perinatal breathing. Reducing antenatal PGE2 concentrations with paracetamol could stimulate spontaneous breathing in premature infants at birth. We aimed to assess feasibility and potential effects of antenatal paracetamol. Methods:...

The Social Function of Property and Real Estate Abandonment: Between Property Law and Environmental Protection

Abstract This article explores the relationship between the social function of property and the abandonment of real estate, arguing that factual abandonment may amount to a form of ‘negligent non-use’ of property. Although the social function of property is both an external limit...

Durability of wrist denervation for osteoarthritis: a multicentre outcome study

INTRODUCTION: Traditional surgical treatments for wrist osteoarthritis, such as arthrodesis or arthroplasty, are invasive and irreversibly compromise joint motion. Wrist denervation offers a less invasive alternative aimed at pain relief while preserving mobility. However, its du...

Management of high-risk (B3) breast lesions in symptomatic practice: evidence review and practical recommendations for multidisciplinary care

Borderline breast lesions (B3 lesions, also termed lesions of uncertain malignant potential or high-risk lesions) represent a heterogeneous group of entities associated with variable risks of malignancy. While the management of screen-detected B3 lesions has become increasingly s...

Implementation of sustainability interventions in ICUs in the Netherlands: A survey of the green ICU

Background The healthcare sector's environmental impact is mostly caused by hospital care, with Intensive Care Units (ICUs) being a significant source of pollution. The Dutch Green ICU network shares sustainability interventions and best practices on its online platform, supporti...

Osteochondral Autograft Options for Reconstruction of Intra-articular Distal Humerus and Proximal Ulna Injuries in Physiologically Young Patients

Purpose Surgical options are limited for distal humerus and proximal ulna injuries with articular bone loss in physiologically young patients. Osteochondral grafts are a potential treatment option between open reduction internal fixation and arthroplasty that does not impart life...

Concordance between plasma biomarkers of phosphorylated tau and tau-PET: A narrative review

Plasma phosphorylated tau (p-tau) and tau positron emission tomography (PET) are key biomarkers for detecting tau pathology in Alzheimer's disease (AD), offering both diagnostic and prognostic value. However, the concordance between plasma p-tau (p-tau217/p-tau181/p-tau231) posit...

‘The real win is doing this for a living’: Routes, routines and rewards of music managers

Studies of the music industry have traditionally prioritized its creative dimensions, especially musicians’ activities. When ‘non-creative’ aspects of music creation are examined, they are typically approached through musicians’ own ‘non-creative’ activities. Despite the insisten...

Discovery–driven capabilities in SMEs: A Kirznerian perspective on firm–level opportunity discovery and adaptation

Small and Medium–Sized Enterprises (SMEs) rarely engage in resource reconfiguration processes. Instead, constrained by their size and scope, they typically renew their existing resources through ongoing adaptive engagement with their environment. This process raises questions whe...

Validation of an Automated Artificial Intelligence‐Driven Planner for Transcatheter Aortic Valve Replacement

BACKGROUND: Preprocedural planning with multislice computed tomography (MSCT) is an essential prerequisite for successful transcatheter aortic valve replacement (TAVR). However, preprocedural planning is time-consuming and may contain clinically meaningful interobserver variabili...

Does social capital improve gender equality?

The relationship between social capital and gender equality has been studied predominantly at the micro-level with mixed but often negative results. Both mixed-gender social capital and women’s social capital do not seem to benefit women as much as men. After developing a theoret...

Perspectives on Placemaking: Affective Practices and the Lived Dimensions of Space

Placemaking is widely promoted as a tool for belonging and urban transformation, yet its affective dimensions remain undertheorized. This article develops a framework for placemaking as an affective practice, arguing that sense of place is best understood through the relational d...

Prognostic Stratification of Brain Metastases from Nonanaplastic Follicular Cell–Derived Thyroid Carcinoma: Results of an International Multicenter Retrospective Study

Background: Brain metastases (BMs) from nonanaplastic follicular cell–derived thyroid carcinoma (hereinafter referred to as non-ATC) are rare and not well characterized, with limited evidence guiding treatment and prognostic stratification. We aimed to describe clinical features,...