Erasmus University Rotterdam

The Effect of BMI on the Image Quality of CTA Scans for DIEP Flap Breast Reconstruction

Background: Computed Tomography Angiography (CTA) imaging is currently the gold standard for the preoperative planning of deep inferior epigastric perforator (DIEP) flap breast reconstruction. Limited research has been performed on the effect of body mass index (BMI) on CTA image...

Effects of GLP-1 receptor agonists on body weight and cardiovascular outcomes: a review

Obesity is a rapidly increasing global health challenge that is strongly linked to the cardiorenometabolic syndrome, cardiovascular morbidity, and mortality. Lifestyle interventions remain the cornerstone of treatment, but average long-term weight loss is modest and durable weigh...

Did the Tiger Grow Fierce Teeth? An Examination of the Use of Criminal Sanctions for Environmental Pollution in China

ABSTRACT Despite an extensive body of environmental law and policy, China's environmental law has long been dubbed a “paper tiger” owning to persistent enforcement failures. Over the past decade, legislative and judicial reforms have substantially strengthened the criminal enforc...

Radium-223 decreases PD-L1 expression in bone metastases: A study with [89Zr]Zr-atezolizumab PET and immunohistological correlation

Abstract Purpose Most patients with metastatic castration-resistant prostate cancer (mCRPC) do not benefit from treatment with immune checkpoint inhibitors targeting programmed cell death (ligand) 1 (PD-(L)1). Radiation might improve response to immunotherapy by increasing the im...

Development and internal validation of a nomogram for visualising multidimensional correlates of baseline suicide‑attempt history among hospitalized adolescents and young adults with mental disorders

Suicide is prevalent among adolescents and young adults with mental disorders (AYAMD). Identifying factors associated with suicide‑attempt history and characterising risk profiles are essential for targeted suicide prevention in this high‑risk inpatient population. The study incl...

Cultural participation as an indicator of local government performance: evidence from Italian municipalities

Abstract This paper investigates whether cultural participation can be interpreted as an outcome-based indicator of local government efficiency in the cultural policy domain. Rather than focusing solely on budgetary effort, the study examines the extent to which municipal cultura...

Enabling Evolutionary Therapy in metastatic cancer lacking serum biomarkers

Evolutionary therapy (ET) aims to anticipate and steer tumor evolution by adjusting treatment timing and dosing, often to control rather than eradicate tumor burden. Clinical use requires reliable monitoring of tumor dynamics to inform mathematical models that guide therapy. In c...

Between Co-Intelligence and Cognitive Offloading: Educators’ Perspectives from Dutch Academic Medical Settings on Generative AI, Critical Thinking, and Adult Professional Learning

Generative artificial intelligence (GenAI) is becoming embedded in adult professional education, yet its capacity to accelerate academic work may also remove cognitive processes that underpin professional judgement. This qualitative study explored how educators working in Dutch a...

Hip and groin pain in physically active adults with a focus on terminology, clinical examination and imaging: A formal ESSKA‐EHPA‐ESMA Consensus

Abstract Purpose This European Society of Sports Traumatology, Knee Surgery and Arthroscopy–European Hip Preservation Associates–European Sports Medicine Association (ESSKA‐EHPA‐ESMA) formal consensus aims to provide evidence‐ and expert opinion‐based recommendations for the term...

Social norms and technology engagement in later life: An experimental study

While previous studies have focused on the importance of self-efficacy and usefulness for willingness to engage with and learn about technology, this study tests whether social norms about the role of elderly people in modern society impact older adults’ intentions to learn about...

Why Politicians Misbehave: A Systematic Review of How Attributes of Political Office Affect Moral Decision‐Making and Behavior

ABSTRACT The moral decision‐making and behavior of politicians is influenced by the distinctive and characteristic attributes of political office. This literature review analyzes 80 articles from public administration, political science and related disciplines to systematically m...

Low-Dose Naltrexone in Crohn’s Disease: A Prematurely Terminated Randomized Trial Showing Reduced Fatigue Without Clinical or Endoscopic Benefit

Crohn’s disease (CD) is often refractory to standard therapies, and patients are sometimes reluctant to initiate immunosuppressive therapy, prompting interest in novel treatments such as low-dose naltrexone (LDN). To evaluate the efficacy of LDN for induction of remission in pati...

Experimental radiotherapy with the gastrin-releasing peptide receptor (GRPR) antagonist [177Lu]Lu-AU-SAR-M1 in a prostate cancer murine model using reduced-frequency dosing

The gastrin-releasing peptide receptor (GRPR) is highly expressed in prostate and breast cancers and hence serves as a legitimate target for radionuclide therapy (TRT). Radiolabeled GRPR antagonists are attractive radionuclide-carriers for TRT, due to their rapid tissue penetrati...

Can Rising Incomes Support Sustainable Well-Being? No Evidence for a “Double Dividend” in the United Kingdom

The double dividend hypothesis suggests that acting in more pro-environmental ways will not only benefit the environment but also carries a subjective well-being premium for those who do so, hence paying off doubly. We test the well-being payoff part of this hypothesis using a tw...

Plurality in transformative change: Three co‐created pathways toward nature‐positive Europe(s)

1.The accelerating decline of biodiversity necessitates transformative change to protect nature and society, requiring innovative actions and governance strategies. This paper focuses on developing diverse transformative pathways for biodiversity in Europe and advancing methodolo...

Robust inference and correlates from genetic associations with personality

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...

Longitudinal analysis of the B-cell receptor repertoire across 30 years of ageing

Abstract Background The gradual decline in the functionality of the immune system during aging is commonly referred to as immunosenescence. This study aims to investigate changes in the B-cell receptor immunoglobulin heavy chain (BCR IGH) gene repertoire during natural aging and...

Prevalence of Acetabular Dysplasia in Early Adolescents From the General Population: A Generation R Study

Background: Acetabular dysplasia is an important risk factor for hip complaints and osteoarthritis in (young) adults. Early identification during childhood is important, as timely intervention may prevent irreversible joint damage. Although traditionally considered an infant-onse...

The Scolioscoop® V3: A low-tech self-assessment tool for patients with adolescent idiopathic scoliosis

Abstract Background Adolescent idiopathic scoliosis (AIS) requires follow-up during growth to detect progression, resulting in a burden of care. The Scolioscoop ® V3 was developed as an alternative to the Bunnell Scoliometer, to facilitate home monitoring by parents/caregivers. A...

Cullin 3 ubiquitin ligase regulates redox defense and metabolic programs in proximal tubule cells

Abstract Background Chronic kidney disease (CKD) is characterized by proximal tubule (PT) stress, oxidative injury, and metabolic dysfunction. Human kidney single-nucleus RNA-sequencing (snRNA-seq) identified enrichment of ubiquitin-dependent protein catabolic processes in injure...