Erasmus University Rotterdam

Brokerage, power and individual innovation:When do brokers act on their structural advantage?

Prior research has found that brokers, those who stand between two disconnected parties, may access non-redundant information that is conducive to higher innovation. However, research has also shown that occupying brokering network positions does not systematically translate into...

Mapping spatial colleague connectivity patterns from individual-level registry data to inform regional pandemic interventions

A concern in infectious disease modelling is how accurately population mixing is incorporated, as it shapes the type and frequency of contacts through which infection spreads, and consequently, estimated intervention effectiveness. Although synthesizing mixing patterns from diary...

Purkinje cells in Crus I and II encode the visual stimulus and the impending choice as monkeys learn a reinforcement based visuomotor association task

Abstract Visuomotor association involves linking an arbitrary visual cue to a well-learned movement. Transient inactivation of Crus I/II impairs primates’ ability to learn new associations and delays motor responses without affecting the kinematics of the movement. The simple spi...

Effect of Aficamten on Cardiac Structure and Function in Patients with Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Aficamten significantly improved both functional capacity and patient-reported health status in patients with symptomatic nonobstructive hypertrophic cardiomyopathy in the phase 3 randomized, placebo-controlled ACACIA-HCM trial (Assessment Comparing Aficamten to Place...

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activatio...

Global Efficacy of Aficamten in Nonobstructive Hypertrophic Cardiomyopathy: Results From ACACIA-HCM

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (nHCM) is associated with significant morbidity with no approved treatment. Aficamten is a cardiac myosin inhibitor targeting excess contractility and diastolic impairment, the predominant mechanism responsible for adverse ou...

Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (HCM) is a common condition that is associated with substantial morbidity and no proven medical therapy. Whether treatment with aficamten, a cardiac myosin inhibitor, can benefit patients with this condition is unknown. METHO...

Underreporting loneliness among older adults: the role of gender, health, partner status, and migration background

Previous research suggests that people belonging to social categories not typically associated with loneliness are less likely to admit feeling lonely. Drawing upon this research, we hypothesized that men, those in good health, partnered individuals, and migrants are less likely...

Comparison of Direct Oral Anticoagulants and Low-Molecular-Weight Heparins in Cancer Patients with Nonvalvular Atrial Fibrillation: Insights from a Single-Center Experience

BACKGROUND: Atrial fibrillation (AF) is frequently encountered in patients with cancer and poses challenges for anticoagulant management. The present study was conducted to compare clinical outcomes associated with direct oral anticoagulants (DOACs) and low-molecular-weight hepar...

Determinants of highly pathogenic avian influenza spread during bird migration

Abstract Migratory waterfowl are central to the global spread of the Goose/Guangdong lineage of H5 highly pathogenic avian influenza (HPAI), yet the parameters and processes shaping their role remain poorly understood, with evidence scattered across studies focused on narrow sets...

Understanding moral trade-offs in pandemic response: A discrete choice experiment on avian influenza policies

Abstract Pandemic preparedness requires navigating trade-offs between health, economic, and social impacts; choices that often involve moral tensions. This study investigates how the Dutch public evaluates such trade-offs in the context of a potential outbreak of highly pathogeni...

The real estate turn in the slum: India’s urban land monetization in comparative perspective

This article contributes to scholarship on Asia’s “real estate turn” through a comparison of in situ “slum redevelopment” programs underway in Delhi and Mumbai that reveals the institutional underpinnings and character of state involvement in each city. Comparative research on st...

Significant other reported outcome measures within European cohorts of severely injured patients: A systematic review

Abstract Purpose Major trauma can have a long-term impact, leading to diminished health-related quality of life (HRQoL) for patients and their significant others (SOs). Patient reported outcome measures (PROMs) make this impact visible, providing expectation- and self-management....

The potential of [18F]FDG PET/MRI for identifying pain sources in patients with diagnostically challenging chronic hip pain after total hip replacement

Abstract Purpose Chronic hip pain after total hip replacement (THR) poses a diagnostic challenge and frequently yields lengthy and unsatisfactory diagnostic work-up. This study aims to evaluate the diagnostic role and clinical impact of [ 18 F]FDG PET/MRI compared with regular di...

New insights into statin-intolerance: biopsychosocial differences, medication beliefs, trust in healthcare and treatment decisions in statin-intolerant versus statin-tolerant patients.

AIMS: This study examined biopsychosocial differences between statin-intolerant and statin-tolerant patients, including their medication beliefs, healthcare trust and influential factors for treatment decisions. METHODS: A cross-sectional survey study was conducted among current...

Health-related quality of life inequalities among patients with T2D in armed-conflict affected populations in Tigray, Northern Ethiopia

War causes tragic loss of life, destruction, and long-lasting quality-of-life distress in armed-conflict-affected populations. After conflict emerged between the federal government of Ethiopia and the Tigray regional government, the destruction of healthcare facilities and the bl...

Invasive and echocardiographic gradients of self- and balloon-expandable valves in failing aortic bioprostheses

Abstract Background Transcatheter aortic valve implantation (TAVI) is an established treatment for a failing aortic bioprosthesis. The hemodynamics of TAVI in degenerated transcatheter or surgical aortic valves (TAV-in-TAV or TAV-in-SAV) are unknown. We aimed to investigate hemod...

Association between psychological frailty index and incident complete tooth loss among middle-aged and older adults: a prospective study based on CHARLS

Complete tooth loss is a severe oral health condition in middle-aged and older adults and is associated with impaired mastication, nutritional problems, reduced quality of life, and adverse ageing-related outcomes. Psychological frailty reflects multidimensional psychological vul...

“A beautiful chaos¨: a qualitative study on exploring the role of international communities of practice in knowledge translation for sexual and reproductive health and rights

Persistent knowledge-to-action gaps in sexual and reproductive health and rights (SRHR) limit the translation of evidence into policy and practice. Knowledge platform Share-Net International (SNI) uses Communities of Practice (CoPs) to support knowledge exchange, yet little is kn...

Pendrin inhibitor PDSinh-C01 reverses salt-sensitive hypertension and metabolic acidosis in the 5/6 nephrectomy rat model

Abstract Pharmacological inhibition of the chloride-bicarbonate exchanger pendrin with PDSinh-C01 potentiates the diuretic action of furosemide in healthy mice. Because pendrin contributes to acid-base regulation and blood pressure control, it may represent an attractive therapeu...