Duke University

Sound Enforcement of Dynamic Release Information Flow Policy

Information flow analysis is the de facto method of assessing confidentiality and integrity issues. However, the widespread adoption of information flow analysis in real-world systems is still lacking, partly due to a fundamental gap between theory and practice: the dynamic natur...

Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling

Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these cues converge on the orphan mitochondrial transporter SLC25A34 to orchestrate lipid...

SHARE: Towards Head-Mounted AR with User-Centric SLAM in Shared Human-Robot Workspaces

Human-Robot Collaboration (HRC) in shared physical spaces using Augmented Reality (AR) interfaces is powered by Simultaneous Localization and Mapping (SLAM). Existing multi-agent SLAM systems rely on an edge server to combine visual findings of multiple resource-constrained agent...

Radiologist and AI performance in detecting mucus plugs on chest CT

Abstract Objectives To compare automated mucus plug detection with radiologist evaluation, assess AI-assisted detection, and examine associations of algorithm-derived airway obstruction burden with COPD severity. Materials and methods This retrospective analysis included 278 COPD...

Werner helicase inhibitor for advanced microsatellite instability solid tumors: a phase 1 trial

Abstract Werner syndrome helicase (WRN) is a synthetic lethal target for microsatellite instability (MSI) cancers. In part 1 of this ongoing first-in-human, phase 1 trial, escalating doses of RO7589831 (VVD-133214), a first-in-class, WRN covalent inhibitor, were evaluated in 88 p...

Patient Risk Factors for Incidental Pathology After Uterovaginal Surgery for Apical Prolapse: Systematic Review and Global Expert Consensus Statements

Abstract Introduction and Hypothesis Uterus preservation is increasingly used for uterovaginal prolapse (U-POP) repair despite ongoing concerns regarding future uterine, cervical, and adnexal pathology. We evaluated incidental pathology rates, associated risk factors, and created...

The Relationship Between Physician Organization and Health Care Use in Traditional Medicare and Medicare Advantage

Publicly funded insurance programs increasingly rely on private health plans to manage care, and physicians have organized into larger groups, many of which are owned by hospitals or health care systems. We examine the relationship between physician organization and health care r...

Genome wide transcriptional changes underlie gradual and recurrent adaptation to protein malnutrition in zebrafish

Lysosome-rich enterocytes (LREs) are a specialized population of intestinal cells that mediate the uptake and absorption of dietary proteins in fish and neonatal mammals. Loss of LRE function causes inhibited growth and poor survival due to protein malnutrition. Previously, we re...

Real‐world outcomes of nivolumab‐ AVD and brentuximab vedotin‐ AVD in paediatric and adult advanced‐stage Hodgkin lymphoma

Summary Brentuximab vedotin (BV)‐doxorubicin, vinblastine and dacarbazine (AVD) and nivolumab (N)‐AVD have transformed the frontline treatment of advanced‐stage Hodgkin lymphoma (HL), yet real‐world comparative data remain limited. In this multicentre retrospective study across 1...

Longitudinal Awake Mouse Brain Imaging Using Functional Ultrasound and Functional Ultrasound Localization Microscopy

Functional ultrasound (fUS), ultrasound localization microscopy (ULM), and functional ULM (fULM) are three emerging brain ultrasound imaging techniques that measure the cerebrovascular structure and function at different spatial scales. Here we establish an awake, longitudinal fU...

Critical first passage percolation on random graphs

In 1999, Zhang proved that for first passage percolation on the square lattice Z2 with i.i.d. nonnegative passage times on each edge, if the probability that an edge has zero passage time is exactly 1/2 (the critical threshold for bond percolation on Z2), then the passage time fr...

How Many PM2.5 Sensors are Needed to Estimate Daily and Annual Deployed-Network Mean Concentrations in City-Scale Sensor Networks?

Abstract Low-cost PM2.5 sensors make it possible to deploy dense networks, but the density required depends on the monitoring objective and local variability. We examined how well smaller subnetworks reproduce deployed-network daily and annual or study-period mean concentrations...

Molecular Methods Reveal Responses of Bacterial Communities, Including Indicator Species, to Ballast Water Management

Ballast water (BW) is an important vector for the global transport of bacterial taxa, including pathogens. The application of molecular tools for evaluating and monitoring BW management practices could improve the accuracy and sensitivity of bacterial detections. However, few stu...

Shared Genetic and Regulatory Architecture of Congenital Heart Disease and Autism Spectrum Disorder Revealed by Cross-Tissue Multi-Omic Integration

Background: Congenital heart disease (CHD) and autism spectrum disorder (ASD) co-occur more frequently than expected, suggesting shared developmental susceptibility. We aimed to identify cross-tissue molecular candidates linking cardiac and neurodevelopmental abnormalities. Metho...

Persistent spatial hotspots and socioeconomic inequalities of snakebite envenoming in Peru: A nationwide spatiotemporal analysis, 2010–2025

Background Snakebite envenoming remains a major neglected tropical disease worldwide, disproportionately affecting rural and socioeconomically vulnerable populations in tropical and subtropical regions. In Peru, snakebite burden is strongly concentrated in Amazonian territories,...

What are the knowledge, use, and perceived benefits and limitations of artificial intelligence chatbots among Italian nursing students? A cross-sectional multicentre study

Exploring students’ knowledge, use, and perceptions of Artificial Intelligence (AI) chatbots may inform strategies in the educational context. However, limited evidence is available on Italian nursing students, leaving this field largely unexplored. A cross-sectional online surve...

Response to geographic song variation predicts differential gene expression in the blood of a songbird

Birdsong mediates territory acquisition and mate choice. In agonistic interactions, local songs generally elicit stronger responses than songs from more distant populations. However, the molecular mechanisms associated with differential responses to local vs. foreign songs are po...

Pheromone circuits and transcriptional cascades modulating transcriptional and chromatin states in the Drosophila central brain with social experience

Abstract Social experience significantly influences the behavioral and physiological responses of animals, including humans. In many animals, social isolation increases aggression, courtship, locomotion, and feeding while disrupting sleep. This occurs when peripheral neurons dete...

Financial Toxicity and Quality of Life After Bone Marrow Transplant: A Longitudinal, Prospective Study

PURPOSE Financial toxicity is common after bone marrow transplant (BMT) and is associated with worse quality of life, but longitudinal patterns remain poorly understood. METHODS We conducted a prospective cohort study of insured adults undergoing allogeneic BMT (2018-2023). Finan...

Association between chiropractic spinal manipulation and adverse vascular events of the head and neck: systematic review and meta-analysis

Abstract Background Observational studies have raised concerns about a potential association between chiropractic spinal manipulation (CSM) and craniocervical vascular events (CCVE), including cervical artery dissection and stroke. We tested the null hypothesis of no significant...