Chinese Academy of Sciences

Temperature-resolved non-additivity in coal–biomass co-pyrolysis: governing roles of coal rank and biomass type in temperature-opposed synergy

Coal–biomass co-pyrolysis offers a flexible pathway for valorizing solid carbon resources, yet contradictory conclusions regarding synergistic effects remain common because conventional evaluations rely primarily on endpoint residue deviations. To address this limitation, a tempe...

Structure based discovery of antipsychotic-like TAAR1 agonists

Abstract Schizophrenia is a severe mental illness whose current treatments primarily target dopamine and serotonin receptors. These drugs often cause side effects and vary in effectiveness across patients. The trace amine-associated receptor 1 (TAAR1), which modulates monoamine s...

From imaging to practice: development and evaluation of reusable kidney models based on multi-case data screening

Prior to surgery, it is crucial to provide junior resident doctors the opportunity to practice partial nephrectomy. Three-dimensional printing is an economical way to provide realistic and reusable kidney models. The purpose of this study was to test the appearance and content va...

Detection of linear deformation features in arctic landfast ice using InSAR and deep learning

Interferometric Synthetic Aperture Radar (InSAR) provides a powerful tool for observing landfast-ice deformation. Linear deformation features (LDFs) are narrow structures associated with fracture development in landfast ice. However, studies on the automated detection of LDFs fro...

Nitrogen–Phosphorus Pollution Dynamics and Export Processes of Anthropogenic Polders in the Middle–Lower Yangtze River: A Regional Review

Polders are typical semi-artificial and human-dominated ecosystems widely distributed in the middle and lower reaches of the Yangtze River Basin. They serve as important sinks and sources of nitrogen (N) and phosphorus (P) in agricultural watersheds. Long-term intensive human int...

The membrane skeleton density of red blood cells in MYH9 -related disease patients is decreased

MYH9-related disease (MYH9-RD) is a rare autosomal dominant disorder caused by mutations in MYH9 gene, which encodes the heavy chain of nonmuscle myosin IIA. Nearly all MYH9-RD patients present with macrothrombocytopenia, characterized by decreased platelet count and increased pl...

CSCProv: causal-semantic consistent provenance graph compression for attack detection

Abstract Provenance graphs have become an important foundation for attack investigation and anomaly detection in enterprise systems. However, system audit logs generate massive numbers of events, resulting in extremely large provenance graphs that not only hinder efficient securi...

Nano-wrinkle waveguides for programmable polariton channeling

Abstract The intrinsic planarity of two-dimensional (2D) van der Waals (vdW) polaritonic media inherently limits the lateral confinement of vdW polaritons. Here, we transcend this geometric limit by introducing a deterministic strategy to engineer non-planar nano-wrinkle waveguid...

Mammalian DNA maintenance methylation depends on histone but not PAF15 ubiquitination

In mammals, DNA methylation is an essential inheritable epigenetic modification maintained by the DNMT1-UHRF1 machinery in a UHRF1 E3 ubiquitin ligase-activity-dependent manner. UHRF1-catalyzed histone ubiquitination and PAF15 ubiquitination have been proposed to recruit DNMT1 to...

A Robust and Lubricating Hydrogel through a High‐Energy‐Storage and Low‐Dissipative Network Design

ABSTRACT Hydrogels are promising joint‐lubrication materials because of their similarity to cartilage. However, most tough hydrogels rely on sacrificial bonds or dissipative networks to improve mechanical strength. These mechanisms inevitably introduce additional bulk energy diss...

Discovery and Semisynthesis of Arthritacins A–J—Terpestacin-Derived Sesterterpenoids from the Plant Endophytic Fungus Arthrinium sp. HS66

Arthrinium species are promising producers of terpenoids with diverse architectures and noteworthy pharmacological properties. In this work, ten undescribed terpestacin-type sesterterpenoids, arthritacins A–J (1–10), together with five known analogues (11–15), were obtained from...

Spatially Constrained Grassland Aboveground Biomass Estimation by Identifying and Masking Achnatherum splendens: Integrating UAV Remote Sensing and Deep Learning

Accurate estimation of forage aboveground biomass (AGB) from unmanned aerial vehicle (UAV) imagery is essential for monitoring alpine grassland productivity and supporting sustainable grassland management. However, the biomass of non-palatable species may be included in remote se...

Ferroelectric Thin‑Film Polarization‑Sensitive Photodetector Based on the Plasmon‑Enhanced Bulk Photovoltaic Effect

ABSTRACT Polarization‑sensitive photodetection is critical for advanced imaging, optical communication, and medical diagnosis technologies. Although detectors based on low‐symmetry metasurfaces or two‐dimensional materials have been widely investigated, they generally suffer from...

Taxonomic insights and preliminary enzyme assays of Rhytidhysteron species (Hysteriales, Hysteriaceae) from litter layer in the Yuan Jiang savanna, China

Six terrestrial hysteriaceous fungi were collected from litter in dry-hot valleys, China, all exhibiting the typical morphological characteristics of the genus Rhytidhysteron. Detailed morphological examimation combined with RAxML phylogenetic analysis of combined LSU, SSU, ITS,...

Creatine-Functionalized Graphene Oxide Membrane Reactor for Efficient Synthesis of 2-Amino-4H-Chromene Derivatives

Derivatives of 2-amino-4H-chromene possess diverse pharmacological activities. However, traditional multicomponent synthesis suffers from toxic solvents, long reaction times, and difficulties in balancing catalytic activity and selectivity, which violates green chemistry requirem...

Stoichiometric deviation and regulatory mechanisms of AOU–nutrient ratio in the oligotrophic Northwest Pacific Ocean

In oligotrophic oceans, the stoichiometric ratios of apparent oxygen utilization (AOU) to nutrients often deviate from the classical Redfield ratio, yet the mechanisms remain poorly constrained. Contrary to the commonly held view that these ratios are typically elevated, we found...

Rodingite‐Derived Melt as a Recipe for Ultra‐Calcic Magmas

Abstract Rodingite is a high‐CaO rock formed by Ca‐rich fluid metasomatism on mafic protoliths. It typically occurs within serpentinite and represents an often‐overlooked constituent of the altered oceanic lithosphere that may be subducted into the mantle. However, the fate of ro...

Mechanistic insights into HipA‐mediated bacterial persistence: Role of initial cellular states and toxin expression kinetics

Abstract Persistent bacteria subpopulations showing multidrug tolerance pose significant challenges to antibiotic therapy. While the HipBA toxin–antitoxin (TA) system is known to play a role in persister formation, existing studies predominantly focus on its kinase activity and i...

Leaf–Litter–Soil C:N:P Stoichiometry Varies with Stand Age in Three Subtropical Plantation Types

Stoichiometry provides an integrative framework for evaluating nutrient dynamics in plantation ecosystems. However, whether stand-age-related changes in leaf–litter–soil carbon (C), nitrogen (N), and phosphorus (P) stoichiometry are consistent among plantation types remains uncle...

Convergent use of aminopeptidase N receptor by hedgehog merbecoviruses

Abstract Coronaviruses circulating in wildlife, such as European and Asian hedgehog merbecoviruses (EriCoVs), pose a potential transmission risk. Knowledge of viral receptors can inform risk assessment and development of countermeasures; however, the functional receptor for EriCo...