Research works

Rapid simultaneous detection of katG S315T and rpoB S531L mutations for molecular screening of multidrug-resistant tuberculosis using a dual LAMP-lateral flow assay

ABSTRACT The global spread of multidrug-resistant tuberculosis (MDR-TB) remains a major challenge to tuberculosis control programs, particularly in resource-limited settings where access to rapid molecular drug-susceptibility testing is limited. Resistance to isoniazid and rifamp...

The Effect of the MTHFR C677T Genotype Polymorphism on the Efficacy of Folic Acid Treatment for Hyperhomocysteinemia and Cardiovascular Endothelial Function

ABSTRACT Background Cardiovascular disease remains a major public health burden. This study aimed to investigate the effect of the methylenetetrahydrofolate reductase (MTHFR) C677T genotype on folic acid treatment response and cardiovascular endothelial function in patients with...

Light as Time: The Photon as the Quantum of a Moment- TER-v3.8

c is not speed through space. c is rate of Time. Light is Time made visible. Photon = t0 = quantum of a moment. Time is Fifth Force from Pure Nothingness N0 = T^0 with particle Nothon. This paper presents TER v3.8 and comparison with independent theory T=C/G2 and Et=M_C/pi_G2 pro...

Developing the Chinese Version of the Sheffield Care Environment Assessment Matrix (C-SCEAM): Translation, Adaptation and Validation

Objective This article aims to (1) translate the Sheffield Care Environment Assessment Matrix (SCEAM) into Chinese and adapt a Chinese version of SCEAM (C-SCEAM), and (2) evaluate the validity and reliability of C-SCEAM. Background While the number of elderly care facilities in C...

Wound blush as a predictor for limb salvage among people with non-healing diabetic foot ulcers

Background and objectives Wound blush represents angiographic visualisation of tissue-level perfusion around a diabetic foot ulcer. While wound blush after endovascular revascularisation (EVR) predicts improved outcomes, its’ prognostic value on diagnostic digital subtraction ang...

Visibility of the Korean National Health Information Portal across search engines and generative artificial intelligence platforms: a repeated cross-sectional study

Objectives: This study assessed changes in the visibility of the National Health Information Portal (NHIP), operated by the Korea Disease Control and Prevention Agency, across conventional search portals and generative artificial intelligence (AI) platforms. Methods: We analyzed...

Politeness Strategies in Permission-Asking Speech Acts: A Cross-Cultural Study of L1 and L2 English Speakers

In interlanguage pragmatics, effective communication enhances pragmatic awareness and mutual understanding, while the art of asking permission enables the speaker to convey clear information, allowing the listeners to comprehend, respond and decide. This cross-cultural study inve...

Astronomical Correspondence in the Textual Architecture of the Qurʾān: Occurrence Ranks, Verse Coordinates and the Metonic Cycle

Version 3.0 is a corrected version. Read CORRECTIONS.md first. This preprint evaluates a reported correspondence between the Qurʾānic co-occurrence of the nouns shams (sun), qamar (moon) and arḍ (earth) and the Metonic cycle (19 tropical years ≈ 235 synodic months). Exactly four...

Cross‐Cultural Dimensions of Communication in Aging: A Review and Update

Abstract This article reviews and updates the current state of communication, culture, and aging research. Although novel avenues of investigation within the discipline continue to evolve, extant research findings are categorized into three principal areas. First, and somewhat co...

Stressors Encountered by Surgical Patients in the Operating Room: A Qualitative Descriptive Study

This qualitative descriptive study aimed to identify the stressors encountered by surgical patients in the operating room through their own expressions and subjective experiences. The study was conducted withinvolved 14 surgical patients who were admitted to the surgical wards of...

Methodological Foundation for Research on Human Cognitive Contribution in AI-Assisted Work

Research on human-AI interaction increasingly relies on naturalistic conversation data, interaction logs and process measures to draw inferences about human cognitive contribution, reliance and capability. This working paper sets out a methodological foundation for such research....

Actor engagement roles in collaborative settings: a theoretical framework and empirical typology

Purpose Despite the recognized importance of actor engagement in collaborative settings, little is known about actors' engagement practices and their influence on collaboration. This paper seeks to conceptualize actor engagement roles, reflecting actors' investment of resources....

Phase Architecture of the OFT-Derived VGM Sector: Control Manifolds, Stability Strata, and Critical Branch Transitions

Building upon the normalized effective-field-theory descent from Organizational Field Theory (OFT) to the Vectorial Gravitational Model (VGM), this paper develops a systematic mathematical framework for identifying, classifying, and testing physically admissible phase structures...

Leveraging the Synergy between Mechanistic Insight and Machine Learning for Predictive Structure–Performance Relationships in Organic Synthesis

Conspectus Understanding how molecular structure determines reaction performance is a central objective of physical organic chemistry and an increasingly important challenge in data-driven organic synthesis. As the frontiers of synthetic chemistry continue to advance, predictive...

Segmentation-based morphometric analysis of neck abscesses on MRI: associations with disease severity

Abstract Objectives Abscess diameter on MRI is an established predictor of clinical severity in neck infections, but this single measurement does not characterize three-dimensional morphology. This study evaluated whether segmentation-derived volume, sphericity, and compactness p...

Reward and recognition practices and healthcare workforce mental well-being: a systematic review

Purpose This study systematically synthesises evidence on how reward and recognition practices influence workforce mental well-being among healthcare professionals in hospital and healthcare settings. Although both monetary and non-monetary approaches were eligible, the included...

Workshop: Introduction to Systematic Review & Meta-Analysis of Animal Studies

Materials associated with our workshop "Introduction to Systematic Review & Meta-Analysis of Animal Studies". In this workshop you will learn the key steps required to conduct a systematic review and meta-analysis of preclinical animal studies. Until further notice, this is an on...

Characterizing Runs of Homozygosity and Inbreeding in American Mink Using SNP Data and Pedigree Information

ABSTRACT Inbreeding increases the likelihood of deleterious recessive alleles becoming homozygous and consequently affecting economically important traits. Runs of homozygosity (ROH), the continuous homozygous segments of the genome and the higher than expected homozygosity (HOM)...

Multiplexed Small-Molecule Detection Using Sequence-Defined DNA Reporters in an Argonaute−Nanopore System

Abstract Multiplexed small-molecule detection remains challenging because chemically diverse analytes lack universal amplification and encoding mechanisms. Here, we present SMART-pore, a programmable molecular encoding-decoding platform, that converts target recognition events in...

TBT-Omega — Transformative Balance Theory: A Candidate Law of Transformative SufficiencyTBT-Omega — Transformative Balance Theory is presented as a candidate theoretical framework and not as a validated universal law. It proposes a candidate law of transformative sufficiency: a transformation can be correctly judged only through a representation that preserves the differences relevant to that judgment. In particular, the final state of a transformation is often an insufficient representation, because different transformations can reach the same final state while differing in process, cost, irreversible loss, reversibility, traceability, alignment, drift, risk, residual future transformability and uncertainty. The central claim is: Complete judgment requires sufficient representation. The framework introduces the transformative balance B-Omega as a candidate sufficient representation for evaluating transformations beyond final outcomes. The main operational principle is: To solve means to leave still solvable. This deposit is a prudent public version intended to establish authorship, timestamp, DOI and external criticability. The theory still requires bibliographic comparison, dataset validation, baseline testing, independent review and empirical refinement.

TBT-Omega — Transformative Balance Theory is presented as a candidate theoretical framework and not as a validated universal law. It proposes a candidate law of transformative sufficiency: a transformation can be correctly judged only through a representation that preserves the d...