Research works

Treatment Efficacy of Imidocarb Dipropionate in Saanen Goats Experimentally Infected with Babesia aktasi

Babesia aktasi is a recently discovered species that is highly prevalent in native goats in Türkiye’s Mediterranean region. Although it does not induce clinical disease in local breeds, it causes severe illness in Saanen goats, manifesting with high fever, anemia, hemoglobinuria,...

High-Precision UT1 Prediction with Different Angular Momentum Combination Schemes

Universal Time (UT1) is a core component of the Earth orientation parameters (EOP). High-precision UT1 predictions are essential for satellite navigation, deep-space exploration, and the maintenance of national standard time. Although effective angular momentum (EAM) information...

Want It Like You Mean It: Revisiting Goal Self-Concordance Through the Dissociation of Autonomous and Controlled Motivation in Relation to Meaning in Life

Abstract The Self-Concordance Model posits that autonomously motivated goal pursuit is a primary driver of well-being, yet standard measurement practices often conflate the presence of autonomy with the absence of external pressure via relative difference scores. Using a high-pow...

Liquid Biopsy for Minimal Residual Disease Assessment in Endometrial and Cervical Cancers: Molecular Rationale, Clinical Evidence, and Translational Barriers

Endometrial and cervical cancers can recur from subclinical disease not evident on routine surveillance. This narrative review critically evaluates liquid biopsy for minimal residual disease (MRD) assessment and recurrence monitoring. Post-treatment human papillomavirus (HPV) cir...

The Role of Neurofilaments in Diagnosis and Monitoring of Amyotrophic Lateral Sclerosis

Background: Amyotrophic lateral sclerosis (ALS), the most common type of motor neurone disease (MND), is a devastating diagnosis that often leads to mortality within 2–5 years of symptom onset. Respiratory failure and aspiration pneumonia both associated with respiratory muscle w...

Alcohol exposure induces reversible nucleolar amyloidogenesis

The nucleolus is a dynamic membraneless organelle that rapidly responds to cellular perturbations. Under harsh environmental conditions, it transitions from a ribosome biogenesis center into a dense proteinaceous structure, known as a nucleolar amyloid body (A-body). Although A-b...

Clinicopathologic mismatch in young-onset parkinsonism: Multiple system atrophy masquerading as a neurotransmitter synthesis disorder

BACKGROUND: Multiple system atrophy (MSA) is a progressive adult-onset synucleinopathy that remains difficult to diagnose clinically, particularly in younger patients and during early disease stages. Brainstem nuclei degeneration resulting in reduced monoamines in cerebrospinal f...

High-Precision Visual Absolute-Localization Method for Deep-Space Probes Based on Salient Landmarks

To address the scarcity of high-precision control points on planetary surfaces and the accumulated drift of conventional relative-localization methods in deep-space exploration missions, this paper proposes a visual absolute-localization method based on salient-landmark contour m...

Mediating Roles of Barriers and Mitigation in Community-Based Health Adaptation to Floods: A Comparative Study in Bandung and Bojonegoro

This study investigates the mediating roles of barriers and mitigation strategies in community-based health adaptation to floods, comparing two contrasting Indonesian regions: urban Bandung and rural Bojonegoro. A cross-sectional survey was conducted with 201 participants (98 fro...

Hattrick against Lymphoma with Trispecific CAR T Cells

Vasu and colleagues report one of the first clinical evaluations of rapidly manufactured trispecific chimeric antigen receptor T cells targeting CD19, CD20, and CD22. The lymphoma efficacy signal and favorable observed safety profile support further investigation, whereas the cor...

Systematic pathway engineering of Escherichia coli for enhanced 3’-sialyllactose production

3’-Sialyllactose (3’-SL), the simplest sialylated human milk oligosaccharide (HMO), is widely incorporated into infant formula due to its roles in shaping the gut microbiota, inhibiting pathogen adhesion, and supporting neurodevelopment. In this study, we developed an efficient m...

Acceptability of Internet-Based Therapy: Considerations Expressed by Individuals Struggling with Gambling

Aims Internet-based therapy (IBT) is effective in reducing symptoms of gambling disorder (GD), yet limited acceptability may constrain treatment uptake and engagement. This study explored perspectives on the expected acceptability (defined as perceiving the intervention as approp...

Space debris and outer space sustainability: legal challenges

By 2025, humankind had reached a turning point in space. The orbital environment, once considered effectively unlimited, is now increasingly understood as a finite and congested operational domain. This article presents an in-depth evaluation of the legal and policy regimes for s...

Persona-centric Metamorphic Relation Guided Robustness Evaluation for Multi-turn Dialogue Modeling

Abstract Retrieval-based dialogue systems aim to select a proper response according to multi-turn conversational history. Persona-based conversation utilizes prior knowledge to maintain persona consistency, enhancing retrieval accuracy. However, reference-based evaluation relies...

Primary Eosinophilic Granuloma of Lymph Node: Case Report of an Enigmatic Disease

Eosinophilic granuloma with solitary involvement of a lymph node is very rare. It occurs mainly in children. We present a rare case report of an adult male with primary eosinophilic granuloma of a lymph node, which had regressed following fine-needle aspiration cytology (FNAC) an...

Understanding, assessing and managing shock in adults

Shock is a potentially life-threatening condition characterised by impaired perfusion of tissues and organs and inadequate cellular oxygenation. If left untreated, shock can lead to organ dysfunction, organ failure and death. This article explores the pathophysiology of shock and...

Competency frameworks for primary care rehabilitation professionals: a scoping review of global practices and implications for developing countries

PURPOSE: Integrated rehabilitation eases chronic mobility dependence, yet competency frameworks struggle to be implemented in resource-limited regions. To map global competency frameworks for primary care rehabilitation professionals and identify specific implications for workfor...

Relationship between neck weakness in motor neurone disease and respiratory function: a retrospective study

AIMS: The primary aim was to explore the relationship between neck weakness in people with motor neurone disease (MND) and their respiratory function. The secondary aim was to identify whether neck weakness can be a prognostic factor. METHODS: This was a retrospective observation...

Firearm carrying practices and motivations: A mixed methods study among adults and youth

Abstract The purpose of this participatory action, mixed methods research study was to identify motivations related to firearm carrying from a qualitative perspective, and then to use quantitative research to characterize the patterns of motivations around carrying. Qualitative i...

Are we well? Burnout among healthcare workers

SUMMARY Burnout refers to a psychological condition arising from prolonged and ongoing interpersonal stressors, resulting in physical and emotional exhaustion. Its prevalence among healthcare workers has been increasingly recognised as a significant factor affecting their mental...