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Optimizing Informed Consent for Australian Newborn Bloodspot Screening and Research: Consensus Workshop Insights and Recommendations

Informed consent is fundamental to Australian newborn bloodspot screening (NBS), but emerging genomic screening technologies pose new challenges to clinical care and research. Optimizing consent processes is necessary to support ethical practice and maintain public trust as NBS e...

Frequency-tunable superconducting microwave resonators based on quantum paraelectricity

Frequency tuning enables both high-sensitivity and wide-bandwidth detection in the resonator. Potassium tantalate (KTO) is a quantum paraelectric with tunable permittivity and low microwave loss at cryogenic temperature, making it promising for tunable devices. Here, we demonstra...

Collaborative craft design with traditional artisans: a participatory design framework for indigenous basketry

This study proposes a participatory design framework derived from collaborative craft design with traditional artisans specialising in indigenous basketry. While participatory design has been widely applied in craft development, design research has rarely articulated how indigeno...

Occurrence and Ecological Significance of Microalgae Species Associated with Egg Clutches of Aquatic Animals

The association of microalgae with aquatic animal egg masses plays an important role in the reproductive ecology of several species. The first descriptions of this phenomenon were reported in 1888 for the egg masses of the spotted salamander Ambystoma maculatum. The microalgae mo...

Digital-twin-enabled reinforcement learning for energy-efficient and reliability-aware software-defined electric vehicles

Software-defined electric vehicles (SDEVs) require intelligent control frameworks that simultaneously optimize energy efficiency and powertrain reliability. However, existing studies typically treat reinforcement learning, digital twins, and predictive health monitoring as separa...

Pleistocene Basaltic Volcanism on the Fly Platform in Papua New Guinea

Papua New Guinea (PNG) remains one of the least studied regions in the Southwest Pacific, and the tectono-magmatic evolution of extensive areas such as the Fly Platform remains poorly constrained. This study presents the first investigation of basaltic volcanism on the Fly Platfo...

Heatwaves and cold snaps alter host-parasite population dynamics

Climate change is increasing the frequency and intensity of temperature extremes, yet the consequences of heatwaves and cold snaps for host-parasite interactions remain incompletely understood.Thermal pulses of ±6°C were experimentally tested to determine how disease dynamics are...

Healthcare professionals’ knowledge and experiences of identifying and supporting young carers: a literature review

Young people who have caring responsibilities, usually for a family member, can experience a range of adverse mental and physical health outcomes. Healthcare professionals have a crucial role in providing these individuals with support, however there is inadequate recognition and...

Long-term outcomes of dual locking-plate fixation for bicondylar tibial plateau fractures via two mini-incisions: A prospective study

Background Bicondylar tibial plateau fractures are complex injuries that frequently involve a posteromedial fragment and carry a high risk of post-traumatic osteoarthritis. However, long-term outcome data on dual locking-plate fixation are limited, particularly in Southeast Asian...

Analysis of Research Progress on Deployment Methods for Deep Learning Models on FPGAs

Deep learning (DL) models have achieved remarkable progress in natural language processing, computer vision, content generation, and edge intelligence; however, their rapidly increasing computational complexity, memory demand, and deployment diversity pose significant challenges...

Assessment of vulnerability to groundwater contamination in the Santa Rosa River basin, Ecuador

Groundwater is a vital resource that supplies nearly half of the world’s population and sustains ecosystem integrity. In the Santa Rosa River basin (SW Ecuador), groundwater plays an essential role due to the variable quality of surface water resources. This study assessed ground...

SDHC c.397C>T- Related Pheochromocytomas and Paragangliomas: Insights from an International Study

BACKGROUND: The SDHC c.397C>T (p.Arg133Ter) germline pathogenic variant is present in over 40% of mutation-positive paragangliomas in French-Canadian patients, supporting a founder effect. We aimed to characterize pheochromocytomas and paragangliomas (PPGLs) associated with this...

Optimising Pharmacovigilance Efficiency with MLIT (Machine Learning for Intelligent Triage): A Tool for Statistical Safety Alerts

BACKGROUND AND AIM: Pharmacovigilance is essential to ensuring patient safety by enabling timely identification of adverse reactions in increasingly complex and voluminous data. Routine quantitative signal detection methods generate statistical alerts for product-event pairs base...

Prioritizing areas for wolf management in Austria by modelling potential habitat and depredation risk

The recovery of wolf populations across Europe has reignited human–wildlife conflicts, particularly in countries such as Austria, where wolves have been absent for more than a century. Livestock depredation remains one of the primary sources of tension, and effective management r...

Roxadustat and incidence of peritoneal dialysis-associated peritonitis: a propensity score–matched cohort study

BACKGROUND: Roxadustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), exerts pleiotropic effects beyond erythropoiesis, including modulation of inflammation and immune responses. Preliminary studies suggest Roxadustat may modulate inflammation to reduce perit...

Emergent flocking dynamics in chemorepulsive active colloids: Interplay of disorder and noise

Recent studies of active colloidal matter have revealed that a global polar order can arise from chemorepulsive interactions among particles without any explicit alignment interaction between them. In this study, we investigate such chemically interacting active colloids in the p...

NADPH-cytochrome P450 reductase mediates P450-dependent metabolic resistance to deltamethrin in Aedes albopictus

The cytochrome P450 monooxygenase system is a key detoxification pathway involved in insecticide metabolism in insects and plays a central role in the evolution of insecticide resistance. NADPH-cytochrome P450 reductase (CPR), a crucial electron transfer partner in cytochrome P45...

Knowledge, Attitudes, and Practices toward Antibiotic Use among the General Public in Andhra Pradesh, India

Objectives: The irrational and extensive use of antibiotics has substantially contributed to the rise of antibiotic resistance among bacterial pathogens worldwide. In developing countries, such as India, easy access to antibiotics without prescriptions further accelerates this pr...

Strengthening mental health systems for suicide prevention: The role of mhGAP in WHO Special Initiative for Mental Health (SIMH) countries

Despite suicide being a leading cause of death worldwide, many countries continue to face challenges providing quality care for people at risk.This paper presents learnings from six countries implementing the World Health Organization's (WHO) Special Initiative for Mental Health...

What drives tourist revisit intention? Destination image, escapism motivation and tourist demographics

This study quantitatively examined how escapism motivation mediates and how tourist demographics moderate the nexus between destination image and tourist revisit intention. Data were randomly collected from 430 tourists visiting recreational and national parks in Zimbabwe. This s...