Research works

Biomechanical responses to increased longitudinal bending stiffness differ between novice and experienced runner profiles

Carbon-plated footwear has primarily been developed and evaluated in trained or competitive runners. However, whether novice runners exhibit similar biomechanical responses to increased longitudinal bending stiffness (LBS) as experienced runners remains unclear. Therefore, the pu...

Prospects of green iron- and steelmaking via the FFC Cambridge process

The FFC Cambridge Process promises green iron-/steelmaking, where the respective metal oxides are used as the cathode in a molten electrolyte. Laboratory tests have validated the process at 500–900°C in molten chlorides, carbonates, fluorides or hydroxides. The reduction proceeds...

Quality Assessment in Frozen Seafood: Advances in Sensing Technologies and Artificial Intelligence

Frozen seafood plays an important role in the global food supply, but maintaining its quality during frozen storage and cold-chain distribution remains a significant challenge. Although freezing effectively slows microbial growth and enzymatic activity, it cannot completely preve...

Efficacy and tolerability of venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukemia – real-world analysis of Polish adult leukemia study group

We collected clinical data on 363 patients with relapsed/refractory chronic lymphocytic leukemia (RR-CLL) treated with venetoclax-rituximab (VR) in a real-world setting. The median age was 69.5 years (range, 32.5–91.6 years), and the median number of prior lines of therapy was 2...

The single cell transcriptional signature of sexual commitment in the human malaria parasite Plasmodium falciparum

<ns5:p> Background Malaria remains a global health challenge, with most fatal cases caused by <ns5:italic>Plasmodium falciparum</ns5:italic> in sub-Saharan Africa. A critical bottleneck in the <ns5:italic>Plasmodium</ns5:italic> life cycle is the transmission from human to mosqui...

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

ABSTRACT Myxoglucamides, natural products recently isolated from Cystobacterineae sp., are featured by an unprecedented vinyl‐substituted α‐keto‐γ‐amino acid that is linked to a glycosylated 14‐methyl‐pentadecanoic acid. Thus, they unite elements from three biomolecular classes i...

Efficacy and safety of repeated low-level red light therapy in myopia control: an updated and comprehensive systematic review and meta-analysis

This study aims to assess the therapeutic effectiveness and safety of repeated low-level red light for myopia management in children and adolescents. Multiple databases were systematically searched for studies evaluating the efficacy of RLRL in myopia control among children and a...

Use of machine learning to enhance detection of transient astronomical phenomena in historical observatory images

Transient, star-like point sources that appear and vanish over short timescales are described in astronomical images prior to launch of Sputnik. We have reported that transient numbers diminish significantly in Earth’s shadow (shadow deficit) and are more likely within (+/-) one...

pyMSscreen: an interactive interface for automated quality control and prescreening in mass spectrometry workflows

Reliable quality control of mass spectrometry data remains a major bottleneck in target, suspect and non-target screening workflows. In non-target analysis, thousands of features can be extracted through automated peak picking, many of which require manual verification to exclude...

Search for neutrino emission from blazar <a:math xmlns:a="http://www.w3.org/1998/Math/MathML"> <a:mi>γ</a:mi> </a:math> -ray flares accounting for possible neutrino time delays

We report the results of the search for the high-energy neutrino emission associated with blazar flares, accounting for a possible lag of neutrinos with respect to the electromagnetic emission, either due to the slowness of the proton energy losses in <mml:math xmlns:mml="http://...

The efficacy and safety of monthly intravenous methylprednisolone pulse therapy in Taiwanese alopecia areata patients: A retrospective cohort study

Abstract Background: Intravenous methylprednisolone pulse (IVMP) therapy has been widely used for treating severe or recalcitrant alopecia areata (AA), but treatment protocols and efficacy vary. Objectives: This study aims to evaluate the efficacy of IVMP, identify predictive fac...

The sweet spot in protein design—Where deep learning meets first principles

This Perspective explores recent methods and prospective ideas for developing hybrid AI-physics-based pipelines for protein and antibody de novo design. We argue that the highest-confidence candidates emerge where deep learning and first-principles models agree, a "sweet spot" th...

Clinical insights: an update on transmucosal absorption with a focus on dodecyl maltoside

INTRODUCTION: Nasal administration provides a favorable option for patients with a variety of disease conditions and their caregivers, including for acute treatment therapies in the community setting. This noninvasive route of administration allows for device portability and quic...

IoT System for Level Monitoring and Control with Point-to-Point LoRa Between Siemens S7-1200 PLCs

Industrial supervision can be expanded through the Internet of Things (IoT) without moving the control logic outside the PLC. This study evaluates a level-monitoring and control architecture using a point-to-point LoRa link between two Siemens S7-1200 PLCs; LoRaWAN is used solely...

Micro-CT radiomics reveals the microcalcification-surrounding tissue interface as the diagnostic epicenter of breast microcalcifications

In clinical breast imaging, microcalcifications (MCs) are routinely interpreted as small radiological signs, typically analyzed in clusters. They guide radiologists in assessing breast lesions and determining the likelihood of malignancy. Yet, increasing biological evidence indic...

Targeting Oncogenic KRAS Using Peptide Nucleic Acid Oligomers Attached to Cell-Penetrating Peptides

Approximately 30% of tumors contain an activating mutation in the oncogene KRAS, leading to increased cell proliferation that often promotes non-small cell lung cancers, colorectal adenocarcinomas, pancreatic ductal adenocarcinomas (PDAC), and other cancers. Among the most common...

Prediction of DistalMutation Effects in Enzymes viaIntegration of Molecular Dynamics Descriptors and Zero-Shot Model

Abstract Identifying beneficial distal mutations remains a key challenge in enzyme engineering, as such residues can regulate activity through long-range dynamical coupling and allosteric communication. Although protein language models effectively capture sequence and evolutionar...

Emergence and Dissemination of NDM+OXA-48-like Co-Producing Klebsiella pneumoniae in a Regional Healthcare Network: Seven-Year Surveillance from Latium, Italy

Background/Objectives: The epidemiology of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) in Europe is evolving towards an increasing contribution of metallo-β-lactamases (MBLs). In particular, co-production of New Delhi metallo-β-lactamase (NDM) and OXA-48-like carbapenemase...

Nones with religious identities: characteristics of those who select both religious and nonreligious identities

Survey research tends to classify individuals as either having a religious identity or having a nonreligious identity/no religious identity. This binary is a function of religious identity questions typically only allowing for a single response. In this study we used unique data...

Depleted uranium final disposal: why classification does not settle long-term safety for large inventories

Depleted uranium (DU) sits at the intersection of radioactive-waste management, resource policy and environmental radioactivity. Its initial specific activity is low, and it may be retained as a potential resource or managed within low-level, low-activity or material-management c...