Research works

Chestnut (Castanea sativa Mill.) leaf extract and pure castalagin reduce bacterial colonisation and the associated inflammation in gastric organoids and a mouse model of H. pylori infection

BACKGROUND: Helicobacter pylori is a bacterium that has been identified as a causative agent in the development of chronic gastritis, peptic ulcers, and gastric cancer. Current eradication therapies, based on antibiotic combination, are suffering from lack of patient compliance a...

Unravelling undergraduates’ development of evaluative judgments through AI-supported internal feedback

Making evaluative judgments is a core lifelong learning capacity and the foundation of student feedback literacy. However, its development in second language (L2) writing remains underexplored. This qualitative case study investigated how 28 undergraduates developed evaluative ju...

A new innovative electronic urology stent registry: Reimagined and automated for the digital era

Objective: To evaluate the safety, completeness, and performance of a fully automated electronic ureteric stent registry designed to ensure full traceability and reliable capture of both retrograde and antegrade stents. Patients and Methods: All stent journeys between May 2022 an...

Optimal Transport-Based Heterogeneous Federated Learning for Chest X-Rays

In some federated learning (FL) scenarios, discrepancies in local client devices result in inconsistent image resolutions, which motivates clients to adopt models with different depths and widths. Existing heterogeneous federated learning methods struggle to maintain model accura...

Teaching Vital Signs Through a Scenario-Based Educational Escape Game: A Quasi-Experimental Study

Objective: This study aimed to compare the effects of a scenario-based educational escape room game on students’ motivation, academic self-efficacy, and achievement levels with those of the traditional question-and-answer method. Educational escape games have recently emerged as...

GSH–AsACycle-Mediated “Vaccine-like”Priming Induced by Low-Dose Polystyrene Nanoplastics Enhances PlantStress Resilience

Abstract Nanoplastics (NPs) pollution poses an increasing threat to agricultural sustainability, yet whether low-dose exposure can prime plant defense responses remains unexplored. Here, we demonstrate that low-dose polystyrene nanoplastics’ (PS–NPs) pretreatment (10 mg/L) allevi...

The combined associations of depression and anxiety symptoms on medical students’ suicide attitudes: a network analysis

Although previous studies have examined the combined associations of depressive and anxiety symptoms on the suicide attitudes of medical students, the number of such investigations is extremely limited. These studies have predominantly employed correlational analyses to conduct a...

Mitigating the Impacts of Macro- and Microplastics on Marine Ecosystems: An Overview of Supporting Strategies and Cleanup Systems

In recent years, plastic litter in marine ecosystems has emerged as a global concern. Consequently, efforts to control, mitigate, and remove micro- and macroplastics from marine systems have intensified. In order to thoroughly analyze this topic, the present work provides a compr...

Calciphylaxis in chronic kidney disease: a systematic review of pathomechanisms and risk factors for calcific uremic arteriolopathy

Calcific uremic arteriolopathy (CUA) is a rare, severe condition affecting patients with chronic kidney disease (CKD). The etiology of CUA is unclear. Here, we aimed to identify factors associated with its development. We reviewed the existing evidence on its pathomechanisms and...

When Treatment Leaves a Mark: Trifluoperazine-associated Hyperpigmentation in a Case Series

Abstract Drug-induced skin hyperpigmentation is a known but often overlooked side effect of phenothiazine antipsychotics. While chlorpromazine is commonly implicated, reports involving trifluoperazine are limited. Because psychiatric treatment is often long term and involves mult...

Community-Based Surgery and Postoperative Survival Among Veterans Affairs Enrollees

Importance: The Veterans Affairs Maintaining Internal Systems and Strengthening Integrated Outside Networks (VA MISSION) Act of 2018 greatly expanded Veterans Affairs (VA) enrollees' access to non-VA (community care) services. Since then, community-based utilization has increased...

Patient‐Reported Outcome Measures Following Pancreatectomy for Pancreatic Cancer: A Scoping Review

BACKGROUND: Patient-reported outcome measures (PROMs) are essential for evaluating quality of life in patients undergoing pancreatectomy for pancreatic ductal adenocarcinoma (PDAC). This scoping review synthesises evidence on PROMs used in this population to guide future research...

Bacterial Community Dynamics and Ecological Characteristics in Temporary Holding Water of Live Seafood Tanks

Temporary holding water in live aquatic-product markets represents a short-term, animal-associated aquatic microenvironment, but its bacterial community dynamics remain poorly understood. In this study, 16S rRNA gene amplicon sequencing was used to characterize bacterial communit...

Sustainable Brake Pad Development: Integrating Micro- and Nano-Sized Ceramic Reinforcements and Carbon Nanotubes for Enhanced Tribological Performance

The development of sustainable, high-performance friction composites is critical for the automotive industry, given the environmental and health concerns associated with conventional brake pad materials such as asbestos and copper. This study investigates the effect of incorporat...

Application of machine learning and deep learning methods for the prediction of near misses and occupational accidents in the construction industry

Abstract Occupational accidents remain one of the key challenges for modern work systems, both from the perspective of employee health and life, and in terms of economic, social, and organisational losses for society. Despite the significant diagnostic value of near misses, data...

Closed‐Loop Solid‐State Synthesis Planning for Materials Discovery With Large Language Models

Developing reliable synthesis routes for complex materials remains a major bottleneck in accelerating materials discovery. This study establishes a large language model-based framework for predicting and optimizing synthesis conditions directly from the literature data. Key synth...

Multifunctional Diluent Enables High‐Voltage and Flame‐Retardant Potassium‐Ion Batteries

ABSTRACT Potassium‐ion batteries (PIBs) emerge as a highly promising candidate system in large‐scale energy storage, owing to their abundant resources, low cost, and potentially high operating voltage. However, the current development of PIBs still faces core bottlenecks such as...

Composite Hydrogel Loading Polysaccharides Derived from Coptis chinensis Franch. for Promoting Diabetic Wound Healing

Efficient treatment of diabetic wounds (DW) remains a major clinical challenge worldwide owing to vascular insufficiency, multiple bacterial infections, and overactivation of pro-inflammatory M1 macrophages caused by hyperglycemia. The development of novel pharmaceutical agents w...

Long-term treatment with sirolimus for pediatric vascular anomalies

Abstract Background Although sirolimus has emerged as a safe and effective treatment modality for unresectable vascular anomalies, comprehensive long-term follow-up data remain scarce in the current literature. This study aims to evaluate the long-term clinical experience of pedi...

Temporal Multi-Omics Reveals Microbial and Metabolic Succession Following Astilbin Treatment in a Human Colonic Model

Background: Astilbin is a bioactive flavonoid with documented anti-inflammatory properties; however, its sustained interactions with the gut microbiota remain poorly understood. Fecal samples from three healthy donors were pooled and fermented with astilbin in an in vitro human c...