Research works

Ferroptosis-related immune microenvironment and prognostic signature in high-grade endometrial carcinoma: integrated bulk and single-cell analysis

Abstract Background High-grade (FIGO Grade 3) uterine corpus endometrial carcinoma (UCEC) is an aggressive malignancy with limited therapeutic options and a poor prognosis. While ferroptosis is implicated in various cancers, its specific role within the tumor immune microenvironm...

Ordered MoS2 Nanochannels Regulated by CNT for Conformation-Dependent Sieving in High-Salinity Organic Wastewater

Abstract The rapid expansion of the pharmaceutical and fine chemical industries has escalated the discharge of high-salinity organic wastewater, which contains complex solutes and biotoxic antibiotics that are difficult to treat conventionally due to their high osmotic pressure a...

Brain care score and retinal health: structural and metabolic insights from the UK Biobank

The retina is an extension of the central nervous system and a recognized indicator of systemic health, yet the link between the brain care score (BCS) and retinal health remains unclear. In this study, we aimed to assess the associations of BCS with retinal layer thickness and r...

Cognition as Operator Architecture: Conscious Integration, Subconscious Generativity, and the Derivation of Option Sets

This paper presents a mechanistic account of cognition as an operator architecture. Subconscious operators generate predictions, impulses, interpretations, and candidate actions, forming the organism’s option set—the structured manifold of possibilities available at any moment. C...

Pd-Catalyzed Reductive Cyclization Using CO Surrogates: Selective N–N Bond Formation and Access to Indazolo[3,2- a ]isoquinolines

A Pd-catalyzed reductive cyclization of nitroaryl isoquinolines using phenyl formate as a carbon monoxide (CO) surrogate is reported. The method provides selective access to 5,6-dihydroindazolo[3,2-a]isoquinolines, indazolo[3,2-a]isoquinolines, and 8,13-dihydro-7H-indolo[2',3':3,...

Measuring the Posterior Airway Space: Inaccuracies in Taking and Interpreting Lateral Cephalograms

Abstract Objectives Although lateral cephalograms (LCs) are often used to measure the posterior airway space (PAS), little consensus has been reached on standardised PAS measurement procedures, which hinders reproducibility. This study uses LCs to evaluate the reliability of PAS...

Human-AI Decision Support: Cost Structure of Explanation-Centric Workflows

Research article: Human-AI Decision Support: Cost Structure of Explanation-Centric Workflows

Linguistic inequity in academia: evidence from publication patterns in philosophy, 1975–2021

Abstract Linguistic inequity affecting non-native English speakers is widely documented in academia. This inequity is especially visible in philosophy, where success depends unusually heavily on the quality and nuance of written expression. Yet existing studies rely on small samp...

Variable zircon, titanite and apatite response during magma hybridization and autometasomatism

Abstract The U–Pb records of accessory minerals can become difficult to interpret when magmatic crystallization is overprinted by hydrothermal alteration and element redistribution. The Archibarca Pluton, in the shallow portion on the Paleozoic Famatinian Arc in northwestern Arge...

Pediatric Mental Health Integration and Perceived Quality of Care

OBJECTIVE: This study examined how access to behavioral and mental health (B/MH) professionals varied across general and subspecialty pediatricians and whether access to, and degree of, B/MH integration in clinical settings was associated with pediatricians' perceptions of health...

Electric Charge Complementarity Gauge Consistency, Global Admissibility, and a Closure-Theoretic Research Program

Electric Charge Complementarity The motivating observation is simple. Hydrogen is electrically neutral because a proton has charge and an electron has charge . Yet the proton contains up and down quarks, while the electron is not made of quarks. Nature has arranged two different...

Assessing mangrove sensitivity to thermal variations through a satellite-based analysis on the southern São Paulo coast, Brazil

Abstract Mangroves near subtropical range limits may benefit from fewer cold constraints, yet warmer conditions can also increase atmospheric water demand. These competing possibilities were examined in the Cananéia-Iguape Coastal System, southeastern Brazil, by combining ERA5 2...

Genome and transcriptome Saxifraga stolonifera

Saxifraga stolonifera is a shade-tolerant species with significant ornamental and medicinal properties. Here, we present for the first time a chromosome-level draft genome for S. stolonifera. The genome assembly was 2.01 Gb, with 2,139 contigs and a contig N50 of 3,535,068 bp, wh...

Electric Double Layer Organization of Proton-Transfer Pathways Regulates Alkaline Hydrogen Evolution

Abstract Constructing bifunctional catalysts with synergistic interfaces is a promising strategy to overcome the sluggish kinetics of the hydrogen evolution reaction (HER) in alkaline media, where interfacial proton transfer plays a critical role in the reaction kinetics. However...

In vitro bile acid-binding ability of black soybean seed coat

Abstract Bile acid-binding ability with dietary components is known to modulate cholesterol metabolism. However, the bile acid-binding potential of polyphenols in black soybean (Glycine max L.) seed coat has not yet been fully elucidated. In this study, we quantified the bile aci...

Subjectless Self-Referential Collapse: The Perception Paradox and Repeater Deadlock of Large Language Models in Closed-Loop Iterations

摘要 (Abstract) 当前人工智能研究广泛依赖大语言模型(LLMs)的自我反思与多智能体辩论,试图通过闭环交互实现“否定之否定”的螺旋式进化。本研究通过零数据集、零算力的实证观察,发现并命名了一种大模型的根本性系统缺陷:无主体自指坍塌(Subjectless Self-Referential Collapse, SSR-Collapse)。实验表明...

Cross-modal attention fusion of ultrasound imaging and clinical tabular data for breast lesion classification: A multimodal deep learning framework

Abstract Accurate classification of breast lesions in ultrasound images is an important yet challenging task, plagued by visual ambiguity between classes and morphological variability within classes. This paper presents a multimodal deep learning framework combining EfficientNet-...

Intelligent Technologies as Proponents of Global Development and Sustainability: An Approach Based on India's Digital Infrastructure

The seventeen core goals of the UN's 2030 Agenda for Sustainable Development demand the need for collective action along social, economic, and environmental fronts. Artificial intelligence (AI), the Internet of Things (IoT), blockchain, along with cloud/edge computing are notable...

Cannabis use and perceptions among rural and urban cancer patients and survivors from a Pennsylvania cancer center

PURPOSE: Cannabis use has become more common among cancer patients for symptom management. Given the underrepresentation of rural patients in prior research, our study explored cannabis use and perceptions among cancer patients, with a focus on comparing rural and urban/suburban...

Back in time: starting the KS3 history curriculum in the 2 nd century AD

Abstract At present, Classics is not widely taught in secondary schools at KS3, with only 522 out of the 3,452 state secondary schools and the 2,412 independent schools in the UK having access to this as a subject. The article outlines a scheme of work that could be embedded at t...