Research works

Design, synthesis, and biological activity studies of formononetin derivatives containing pyrazole amide moieties

Abstract BACKGROUND Global food security faces dual challenges from pathogen threats and increasing fungicide resistance, urgently necessitating the development of new pesticides that are efficient, low‐toxicity, and environmentally friendly. Natural products, owing to their stru...

Low Dasatinib Penetration of the Blood–Brain Barrier in Children With Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia: Evidence From LC‐MS/MS Analysis

ABSTRACT We measured dasatinib concentrations in paired plasma and cerebrospinal fluid (CSF) samples from children with Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL). Blood samples were collected from children at 0 h (pre‐dasatinib) and 2 h post‐dasatini...

Commodities, States, Land, and Environments in Southern African History

This introduction to the mini-special issue on commodities, states, land, and environments in southern African history frames commodities as a critical lens for reinterpreting the political, social, and environmental histories of southern Africa from the colonial period to the pr...

Computationally Efficient Robust Information Filtering for In-Flight GNSS/SINS Tightly Coupled Navigation with High-Dimensional Observations on Small UAVs

The full operation of BDS-3 enables users to obtain high-performance positioning services, benefiting from the surge in the number of Global Navigation Satellite System (GNSS) observations with multi-constellation multi-frequency signals. This overabundance is beneficial to impro...

Game-based learning in cardiology: assessing the effect of puzzle games on medical students’ perceptions and clinical reasoning

Developing clinical reasoning for diagnosing cardiovascular diseases is a major challenge in undergraduate medical education because learners must integrate fragmented clinical information into coherent diagnostic hypotheses. Puzzle game-based learning (GBL) has the potential to...

Lanthanide Centered and Circular Polarized Luminescence (CPL) From Tb(III) Complexes Made From Structurally Simple Methoxy‐Phenyl and Phenol‐Derived Pyridyldiamide (pda) Ligands

ABSTRACT The chiral pda derived anisole ligands L1a [ 1( R,R )] and L1b [ 1( S,S )], along with their phenol derivatives L2a [ 2( R,R )] and L2b [ 2( S,S )], were used for lanthanide‐directed synthesis of their respective Tb(III) complexes. Under thermodynamic control, the 3:1 (l...

Nature contact and adolescent paper-reuse behavior: place attachment versus climate anxiety in a two-wave study of Chinese adolescents

Nature contact is often linked to pro-environmental behavior, but the psychological processes connecting these experiences to later behavior remain unclear. This study examined reusing paper and compared two theoretically distinct pathways: a positive-bonding pathway through plac...

NIR-activated NO-propelled nanomotors for deep tumor penetration and DNA-repair sensitized photothermal therapy of prostate cancer

Photothermal therapy (PTT) for solid prostate cancer (PCa) is often limited by poor intratumoral penetration and rapid DNA repair. Herein, we engineered a PSMA-targeted gas nanomotor that couple deep tumor penetration with DNA repair sensitization for enhanced photothermal/NO the...

BASE 44 ORDER: Extract cluster 43 vectors, integrate into isomorphism module, cross-match E8 benches — E8 Intelligence Research

Andrew's order (Base 44 console): [SELF-BUILD from enhancement #466] Extract cluster 43's geometric vectors from research swarm. Integrate into pattern detection engine's isomorphism module. Add cross-domain structural matching to E8 replay benches. Validate against known domain...

Accumulation, toxicity, and underlying mechanisms of short-chain chlorinated paraffins in early life stages of Chlamys farreri

Short-chain chlorinated paraffins (SCCPs) have attracted extensive attention due to their wide distribution and associated human exposure risks. Although marine bivalves exhibit a high accumulation capacity for SCCPs, their toxicological effects and underlying mechanisms remain p...

EuroMillions Breakthrough Mining — 1682 Sources, 12320 Leads Extracted — E8 Intelligence Research

Mined 1682 lottery+quantum breakthroughs. Extracted 12320 leads across 13 categories. 10336 high-value leads found. Categories: {"CORRIDOR": 1022, "FORMULA": 866, "GEOMETRIC": 718, "FORWARD_ATTEMPT": 1071, "QUANTUM": 1284, "TIMING": 204, "CELESTIAL": 950, "GEMATRIA": 1018, "CONST...

The Physics of the Outer Boundary: Beyond Popper's Tyranny in the Belsky/Russell Resonant Unied Field Theory

This paper introduces a critical examination of the Outer Boundary within the Belsky/Russell Resonant Unified Field Theory (RUFT). It addresses the limitations of conventional empirical paradigms, here termed “Popper’s Tyranny,” in fully accounting for the deterministic coherence...

Application of an Off-Design Transient Simulation Framework for Pump-as-Turbine in OpenFOAM: Validation and Flow Analysis

Pump-as-Turbine (PaT) systems represent a cost-effective solution for hydraulic energy recovery in existing water networks and industrial processes. However, the prediction of their performance in turbine mode remains challenging, especially under off-design conditions where unst...

Building trust in timber construction: stakeholder perceptions and barriers to adoption in Mexico

Introduction: The construction sector faces growing pressure to reduce embodied emissions while maintaining technical performance, affordability, and long service life. Timber may contribute to lower-carbon construction, although its environmental value depends on forest origin,...

Recovery-Primed Stimulation: A Proposed Framework for Controlled Triggering of Healing-Related Physiology in Low-Grade Chronic Inflammation

Low-grade chronic inflammation (LGCI) is considered a heterogeneous, persistent, high-burden biological state rather than a single disease entity. In LGCI, inflammation-related pathways can reinforce each other, creating a self-sustaining inflammatory state. This creates a treatm...

Why Are Cascade Birth Interventions Rising?

The increasing use of birth interventions has prompted global policy and research focus. This study attempts to enhance our understanding of why this increase is occurring. Using a population-based dataset of over 1.3 million births in New South Wales, Australia (2004–2018), we i...

From learning to action: transformative pedagogies driving SDG-oriented entrepreneurship in higher education

Purpose This study aims to analyze how project-based learning (PBL) in higher education entrepreneurship courses contributes to the development of sustainable entrepreneurial competencies and to students’ social and environmental commitment, highlighting its relevance to the achi...

A SustainablePathway for CO2 Utilization:Pd(II)-Embedded Diamino-Functionalized Al(III) MOF Catalyst with HighCO2 Sorption Affinity Enabling Recyclable Synthesis ofBioactive Quinazolinones under Atmospheric Pressure Conditions

Abstract Quinazolinone derivatives are an important class of nitrogen-containing heterocycles that serve as key intermediates in the synthesis of biologically active compounds. Sustainable synthesis of such heterocyclic compounds via CO2 utilization represents an attractive strat...

Emergency care use in early pregnancy and adverse maternal events at birth and up to 42 days postpartum among North Carolina Medicaid beneficiaries

Abstract Objective Emergency care (EC) utilization can indicate unmet medical or social needs. In pregnancy, EC use may identify individuals at risk for adverse outcomes and highlight opportunities for intervention. This study examined the association between EC use in early preg...

Field-Validated Induced-Voltage Testing and Power-Supply Capacity Calibration for Converter Transformer Systems Considering Parasitic Capacitance

Field voltage testing after the maintenance of large converter transformers requires high-voltage response verification while preserving the restored equipment boundary. However, conventional direct voltage application on the grid side usually requires the disconnection of high-v...