Research works

Follow-up investigation of ethics approvals and regulatory compliance in publications from the IHU-Mi

Abstract Background Following our previous investigation of 456 articles published by the IHU-Méditerranée Infection (IHU-Mi) institute in Marseille, France, subsequent editorial actions, institutional reviews, and reports from French authorities provided additional evidence rele...

Establishment of a human osteocyte model to reveal mechanisms of chronic Staphylococcus epidermidis bone and joint infections

Aims Chronic bone and joint infections caused by Staphylococcus epidermidis can be difficult to treat and are prone to recurrence. In this study, established human osteoblast- and osteocyte-like cell line models were used in vitro to investigate the intracellular persistence of S...

EID1-EP300 axis dysregulation in airway fibroproliferation: a single-cell transcriptomic analysis with implications for tracheostomy-associated granulation

Abstract Background Tracheostomy is a common life-saving procedure, yet recurrent granulation tissue formation at the tracheostomy site remains a challenging clinical problem with unclear mechanisms. Current endoscopic resection offers only temporary relief, and the molecular dri...

Multiscale SynapticDynamics of T-Cell AntigenRecognition

Abstract T-cell antigen recognition plays an essentially important role in adaptive immunity, enabling pathogen clearance and the elimination of abnormal cells. Recent studies have identified the force-dependent property of TCR–pMHC (TM) bonds as a key for antigen recognition, wi...

Concomitant ablation of SOS1 and SOS2 triggers a lethal phenotype involving compromised intestinal integrity and widespread septicemia

Abstract The RAS guanine nucleotide exchange factors Son of Sevenless 1 and 2 (SOS1 and SOS2) are key regulators of RAS signaling pathways controlling cellular proliferation, differentiation, and survival processes that are essential for correct tissue homeostasis. While mice lac...

SecureX: A CCTV & Security Service Booking and Management System — Technical Report

SecureX is a web-based CCTV and security service booking and management system developed to digitize the workflow of security service providers. The platform enables customers to browse security services, create accounts, authenticate using traditional credentials or Google OAuth...

Koalas in continuous time – unravelling the movement ecology of an iconic species using insights from a statewide telemetry program

Abstract Movement ecology has entered an era of unprecedented data abundance, yet contemporary GPS datasets present analytical challenges due to temporal autocorrelation between consecutive locations. Continuous-time movement modelling (CTMM) addresses these challenges by treatin...

Analysing Korean children's speech data for early childhood educational services: age-specific insights from text and audio analysis

Abstract As speech-based artificial intelligence (AI) becomes integrated into educational contexts, attention is growing towards its role in supporting child-centred learning environments. This study offers insights for developing child-friendly conversational AI systems by analy...

Generative Paper 14 — Quantum State & Measurement: Presentation-Level Constraints in Generative Architecture

The Quantum State is established in the Generative Architecture as the presentation-level operational domain of an organization composed of projected cycles. Realization generates organizational structure through recursive execution, projection exposes realized organization throu...

Microbial levan potentiates hepatic retention and antitumor activity of a PEGylated benzimidazole–curcumin nanocomplex through TLR2–FXR/FGF15-associated immunometabolic remodeling in experimental liver cancer

Abstract Despite major advances in nanomedicine, therapeutic efficacy remains constrained by unfavorable host responses that influence nanotherapeutic retention, biodistribution, and activity. Biological strategies capable of enhancing nanomedicine performance through modulation...

Effects and safety of magnetic lidocaine microsphere as novel strategy to targeted long-acting peripheral nerve blocks

Abstract Background Local anesthetics have been a cornerstone in the field of anesthesia for over a century, yet they face ongoing challenges in providing sustained postoperative analgesia. The ideal duration for such analgesia is 48–72 hours, a benchmark that current formulation...

AI and Financial Risk Governance in Emerging Markets: Regulatory Gaps and Structural Exposure in Latin America

Artificial intelligence is reshaping credit assessment, fraud detection, payment infrastructure, and systemic risk monitoring across the global financial system. Yet the scholarly literature documenting this transformation is geographically lopsided: bibliometric reviews of AI in...

Assessing iron, zinc and calcium bioaccessibility using the INFOGEST method: Challenges and opportunities

Abstract Iron, zinc and calcium are essential minerals required for key physiological functions, including oxygen transport, immune function, enzymatic activity and bone health. Despite their importance, deficiencies remain widespread globally, driven in part by the poor bioavail...

Programming Supramolecular Polymerization Pathwaysthrough Aromatic Mutation and Photoresponsive Switching

Abstract Precise control over supramolecular polymerization pathways remains a central challenge for peptide-based materials. Here, we demonstrate that minimal structural mutation via the systematic deletion of aromatic residues provides a powerful handle to program pathway compl...

The Entity That Forms Subjects (EFS): Ontological Status, Properties, and Place in the Hierarchy of Forms of Matter

Correct short title in 8 languages: 1. Русский: Сущность, формирующая субъекты (СФС) 2. English: The Entity That Forms Subjects (EFS) 3. Français: L'Entité qui forme les sujets (EFS) 4. Español: La Entidad que forma sujetos (EFS) 5. Deutsch: Die Entität, die Subjekte bildet (EFS)...

Genicular artery embolization for refractory pain after knee arthroplasty: clinical outcomes from a retrospective pilot study

Abstract Background Refractory pain after knee arthroplasty without prosthetic loosening, infection, or mechanical failure remains a therapeutic challenge for which few non-surgical options are available. Genicular artery embolization (GAE) has shown promise in knee osteoarthriti...

CAT'S THEORY PRESENTS: Shell, Wish, and Noise: A Third Axis for Modal Evaluation

We identify Shells — propositions that are formally valid and actually instantiated but arise at worlds where no narrowing of the accessibility relation has occurred — and prove by bisimulation that the narrowing condition is inexpressible in standard multi-modal logic. A triadic...

Nanoscale Formation,Structure, and Stability of Phosphate-IronColloids at Anoxic-Oxic Interfaces

Abstract The mobility of phosphorus (P) at anoxic–oxic interfaces is largely controlled by the formation of phosphate-iron (Fe) colloids, yet the nanoscale mechanisms underlying their formation, structure, and stability remain poorly described. Here, we systematically investigate...

Step-ScanInterferometry for High-Fidelity HyperspectralNanoscopy

Abstract Fourier transform infrared nanospectroscopy (nano-FTIR) is an increasingly adopted characterization method that leverages decades of established knowledge in infrared spectroscopy at the nanoscale. It enables detailed characterization of composite materials and nanophoto...

Physics from Existence I: The Equation

No theory has simultaneously derived all 26 free parameters of the Standard Model. In this paper, extending the quantum indefiniteness of existence to the existence of the universe itself, we show that three axioms about existence — existence is bivalent (n ∈ {0,1}, i.e. n² = n),...