Research works

Unraveling theR-Enantiomer Preference in Mirror-ImageCyclodextrin: An Integrated Multiscale Computational Study

Abstract L-β-Cyclodextrin (L-CD), the mirror-image isomer of native β-cyclodextrin, provides a conceptually novel chiral microenvironment for pharmaceutical enantioseparation; however, its full separation potential and recognition mechanism remain largely unexplored, hindering it...

Transfusion-sparing anesthetic management and immediate extubation in pediatric liver transplantation

Abstract Background Blood-sparing anesthesia and rapid recovery are central in pediatric liver transplantation (PLTx). The aim of this study was to describe the intraoperative anesthetic management adopted by a dedicated team. Methods This is a retrospective study performed at IR...

Different Contexts, Common Aspirations: Why Young People Must Be Partners in Sustainable Development

Young people across the world face sharply unequal starting conditions, shaped by geography, access, identity, institutional context, and exposure, yet international research and PURE's field experience point to recurring aspirations for dignity, education, livelihoods, safety, a...

Modelling the biomechanics of the human iris with an active strain approach

Abstract The iris is a deformable circular diaphragm that regulates pupil size in response to changes in illumination through the antagonistic actions of sphincter and dilator muscles. While the phenomenological relationship between pupil size and light intensity is well studied,...

Novel Hydrazide-Based Ionic Liquid Aqueous SolutionsRealize CO2 Capture through the Multisite Synergistic Actionof N and O Atoms

Abstract A new strategy for enhancing the hydrazine structure based on the inductive effect and conjugation effect of strong electron-withdrawing groups has been designed to effectively absorb CO2 with hydrazide-based ionic liquids (ILs). All three ILs aqueous solutions (diethyle...

Characterization of the rock pigeon type IV interferon system reveals conserved tyrosine-based signaling via the IFN-υR1/IL10RB complex

Abstract Type IV interferon (IFN), a recently identified class of IFN, exhibits broad-spectrum antiviral and antibacterial functions across species. In this study, the type IV IFN gene, IFN - υ , and its cognate receptor subunits (IFN-υR1 and IL10RB) were functionally characteriz...

GPRBase: A Free Library of Real-World Ground Penetrating Radar Datasets for Education, Training and Research

Ground Penetrating Radar (GPR) is a routine tool in civil engineering, utility detection, geotechnics, archaeology and the geosciences. Its theory can be taught from a textbook; interpretation cannot. Interpretation is learned by working through many real radargrams, and suitable...

Fungal infection leading to pulmonary inflammation

This study investigates how gut microbiota-derived metabolites modulate pulmonary immune responses to Aspergillus fumigatus infection. We employed a multi-omics approach to characterize the functional impact of antibiotic-altered gut microbial communities on lung inflammation in...

Relationship between 21st century skills and clinical decision-making in Generation Z nursing students: a cross-sectional study

Abstract Background The complex and rapidly changing nature of modern healthcare environments requires future nurses to possess advanced competencies. While 21st-century skills are theoretically expected to enhance nursing students’ clinical reasoning, empirical research explorin...

Concerted action of gammaherpesvirus infection and moderate hyperoxia on lung structural development including effects on critical lung fibroblast functions in neonatal mice

Abstract Background The development of chronic lung disease, also known as Bronchopulmonary Dysplasia (BPD), is the most prevalent complication after premature birth. Viral infections are discussed to drive or aggravate lung disease, but only little is known about their role in B...

Ontology of Emergent Spacetime Based on the Non-Existence of Time and the Trajectory of a Single Source

This paper proposes a novel ontological model in which the universe does not exist as an objective background spacetime, but emerges relationally through the ultra-high-speed trajectory (projection) from a single fundamental information source. We reject the traditional paradigm...

John Stewart Turner

Abstract Black and white portrait showing John Stewart Turner, an older man with a receding hairline, wearing thick-framed glasses, a light-colored textured suit jacket, a white shirt, and a light-colored tie with a dotted pattern. He smiles slightly and looks directly forward. B...

Photonic Balanced Ternary Computing: A Perspective on the Post-CMOS Paradigm

Binary logic on CMOS emerged from the two-state operating regime of 1940s vacuum tubes — a historical contingency, not a law of physics. This perspective argues that three developments — the quantum transport physics of photonically gated carbon-nanotube devices, balanced ternary...

Spatiotemporal dynamics and climate correlates of Parkinson disease mortality among older U.S. adults: national trends and forecasts to 2035

Abstract Background Parkinson disease (PD) is an increasing cause of mortality among older adults, but national studies have generally examined mortality trends, forecasts, spatial variation, or environmental associations separately. We integrated these components to characterize...

Relational Rationality and Ontological Symbiosis: An Axiomatic Framework for AI Alignment

This conceptual preprint proposes the Khristoliubov Law as a two-level framework: a conditional formal law of relational rationality for agents with relational viability, and an ontological postulate concerning the convergence of sufficiently developed cognitive agents toward sym...

The relation between cardiovascular calcifications and diffuse idiopathic skeletal hyperostosis

Abstract Introduction Diffuse idiopathic skeletal hyperostosis (DISH) has been associated with vascular calcifications, but data are inconclusive. We aimed to assess the association between DISH and calcifications of the coronaries, thoracic aorta, aortic valve, and mitral annulu...

Effects of insoluble surfactants on breaking waves: regular and spilling regimes

We investigate the influence of insoluble surfactants on the spatio-temporal evolution of breaking waves, focusing on both regular and spilling regimes. Three-dimensional direct numerical simulations are conducted using an interface-tracking/level-set method that incorporates sur...

Spin(10) chiral gauge theory on the lattice: the construction, its single assumption, and a conditional nonperturbative definition

This deposit contains one paper and the deterministic scriptsreproducing every computed statement in it.The paper defines a chiral Spin(10) gauge theory on the lattice infull — gauge group, field content, lattice and measure, a singleG-invariant gapping interaction, and the order...

Mapping the NASH-CHECK to the EQ-5D-5L in a MASLD population in seven European countries

Abstract Background Metabolic-dysfunction associated steatotic liver disease (MASLD) is a progressive chronic liver condition characterised by substantial inter-patient variation in disease severity, with the probability of progressing to hepatic fibrosis, cirrhosis or hepatocell...

TUS OS Paper 4 — Technical Volume I: Formal Foundations and the Complete-Future Corpus

Abstract TUS OS Paper 4 — Technical Volume I: Formal Foundations and the Complete-Future Corpus establishes the formal and computational foundation for the whole-Triad state-and-process synthesis programme developed across Paper 4. It fixes the governing source hierarchy, inherit...