Research works

Advances and Applications of Computational Design Methods in Structural Design

Abstract Computational design has profoundly influenced structural design. However, its integration into the structural design workflow remains limited, leaving considerable room for further development. To facilitate a more systematic review of this topic, this paper proposes a...

Risk factors and antifungal resistance in Candidozyma auris bloodstream infections in Southern China

Abstract Background Candidozyma auris , also known as Candida auris , is an emerging multidrug-resistant fungal pathogen that represents a major global health concern; however, its risk factors and antifungal resistance patterns in bloodstream infections (BSIs) in Southern China...

The Entity That Forms Subjects (EFS): Ontological Status, Properties, and Place in the Hierarchy of Forms of Matter

Correct short title in 8 languages: 1. Русский: Сущность, формирующая субъекты (СФС) 2. English: The Entity That Forms Subjects (EFS) 3. Français: L'Entité qui forme les sujets (EFS) 4. Español: La Entidad que forma sujetos (EFS) 5. Deutsch: Die Entität, die Subjekte bildet (EFS)...

Generative Paper 13 — Vector Point & Projected History: Architecture of Quantum Projection Geometry

Within the Generative Constraint Framework, projection establishes a descriptive level at which organizational realization becomes explicitly representable without reducing it to conventional physical geometry. Quantum Projection Space (QYZ) provides this projected organizational...

The rise of state-centric biophysics: integrating orthogonal molecular readouts across biophysical scales

Abstract Modern biophysics has evolved from the measurement of isolated molecular properties toward increasingly integrated molecular characterization. Advances in instrumentation, orthogonal workflows, and multidimensional analytical platforms have expanded the breadth of molecu...

Two cases of lysozyme-induced nephropathy with varying underlying diseases: myelodysplastic syndrome and chronic myelomonocytic leukemia

Abstract Lysozyme-induced nephropathy (LyN) is a rare kidney complication associated with chronic myelomonocytic leukemia (CMML). This condition is characterized by distinctive pathological features, including granules within proximal tubular cells that stain positively with peri...

Matrix-DependentPerformance of β-GlucanComposite Films Functionalized with Phenolics from Passion Fruit SeedWaste

Abstract The valorization of agro-industrial waste for producing sustainable and functional packaging is a key strategy within the circular economy and green chemistry. This study developed active antioxidant edible films by incorporating a phenolic-rich extract from yellow passi...

Transcriptome expression profiles and regulatory networks in patients with heart failure following myocardial infarction

Abstract Background The molecular mechanisms underlying heart failure (HF) following myocardial infarction (MI) (HF-MI) remain incompletely understood, and discoveries from whole-transcriptome profiling hold significant promise for disease prevention and treatment. Methods Whole-...

Common genetic mechanisms between obesity and COVID-19 severity: unravelling pleiotropic loci and biological pathways

Abstract COVID-19 and obesity are complex conditions marked by immune and metabolic dysfunction, with the former still ranking among the leading causes of death from infectious diseases worldwide and the latter reaching pandemic proportions. Clinical evidence consistently shows t...

Do sectarian differences affect support for armed non-state actors? Evidence from survey experiments in Lebanon, Iraq, and Yemen

Abstract Sectarian cleavages are widely seen as central to Middle Eastern conflict, and Iran-backed armed non-state actors (ANSAs)—Hezbollah, the popular mobilization units, and the Houthis—are often portrayed as sectarian militias. Yet there is little empirical evidence that pub...

Multidisciplinary Delphi consensus-based recommendations on the use of image-guided radiotherapy for upper gastrointestinal tumours: an AIRO–AITRO–AIFM study

Abstract Objectives Upper gastrointestinal (GI) malignancies represent one of the most challenging scenarios for image-guided radiotherapy (IGRT). Despite technological advances, clinical practice remains heterogeneous among centres. This national, multidisciplinary Delphi consen...

Different Contexts, Common Aspirations: Why Young People Must Be Partners in Sustainable Development

Young people across the world face sharply unequal starting conditions, shaped by geography, access, identity, institutional context, and exposure, yet international research and PURE's field experience point to recurring aspirations for dignity, education, livelihoods, safety, a...

Tullio Pozzan

Abstract Portrait of Tullio Pozzan, a man with white hair and blue eyes, wearing a dark suit, white shirt, and patterned dark blue tie, looking forward with a slight smile. Below the portrait is his handwritten signature. Tullio Pozzan was a pioneer at the forefront of cell physi...

Learning to be inaccurate like an adult: Using computational cognitive modeling to investigate the acquisition of pronoun interpretation in Spanish

Abstract When children behave differently from adults in language tasks, it is often unclear if the underlying cause is non-adult-like representation of relevant information, non-adult-like deployment of adult-like representations, or both non-adult-like representations and non-a...

Trends in the PromisingFunctional Pigment, Phycocyanobilin:Preparation, Health Benefits, and Utilization

Abstract Phycocyanobilin (PCB) is a linear tetrapyrrole chromophore covalently bound to phycocyanin that is widely distributed in cyanobacteria and certain microalgae. PCB has attracted increasing attention, because of its well-defined structure, excellent biocompatibility, and d...

Warning Cairo Before the Air Turns Dangerous: Forecasting High-AQI Episodes for Citizens and City Governments

The ProblemAir-quality forecasts exist to warn citizens before pollution reaches dangerous thresholds. However, the machine-learning literature overwhelmingly evaluates these models using Mean Absolute Error (MAE). Because air quality is highly autocorrelated, naïve persistence m...

Clustering and customer value to enhance the competitive advantages of the palm and date sector in the Jericho governorate

Purpose This study aims to develop a comprehensive strategy for creating and enhancing customer value in the palm and date sector in Jericho Governorate by leveraging the potential of palm and date clusters. Design/methodology/approach A quantitative methodology was adopted using...

Physicochemical indicators and recurrence of urolithiasis in patients with hyperuricemia: a predictive model

Abstract Objective To identify metabolic predictors of urolithiasis recurrence and investigate whether the predictive value of urinary citrate differs across metabolic subgroups, with the aim of developing a subgroup-specific prediction model. Methods We retrospectively analyzed...

Machine learning based ECG analysis with data augmentation for fatigue status detection in elderly individuals

Abstract Fatigue detection in elderly individuals is critical for preventing health complications and enhancing quality of life. Electrocardiogram (ECG) signals offer a non-invasive way to capture fatigue-related physiological changes, but few solutions are lightweight, interpret...

fourSynergy: ensemble-based interaction calling on 4C-seq data using gradient-free optimization

Abstract Background Chromatin organization plays a crucial role in gene regulation and is associated with various severe diseases like cancer. Since chromatin changes are potentially reversible, a deeper understanding of the alterations could be harnessed for the development of n...