Research works

Identification of vaccine candidates by immunization with a complex pool of recombinant VLPs

Identifying the regions of a protein that can be readily translated into an effective vaccine remains a major challenge in epitope-focused vaccine design, especially when a protein is poorly characterized. Here, we describe an immune-driven strategy for epitope identification whi...

Regime Equivalence and Refinement: Transport, Normal Forms, and the Boundary of Declared Change

Abstract This second-edition layer develops the retirement calculus implicit in Regime Equivalence and Refinement v1.0. Holding the frozen regime and carrier fixed, retirement removes declared demands and therefore moves in the direction opposite refinement: fewer demands induce...

A dual-mode radiofrequency ablation catheter with advanced thermal sensing for saphenous and perforator vein insufficiency: a preclinical study on goats

为克服现有进口器械热损伤风险高、 与国内临床常用的 6 Fr 鞘管不兼容等局限性, 我们研发了一款名为 Saphenus 的新型国产射频消融 (RFA) 导管系统。 其核心创新点包括: 6 Fr 外径设计 (适配国内常用鞘管), 独特的双模工作长度设计 (8 mm 用于穿通静脉, 80 mm 用于大隐静脉), 以及优化的温度传感机制以...

Effect of cobalt doping on NiSe2-based sensing electrode for non-enzymatic electrochemical ascorbic acid detection

Ascorbic acid is an essential antioxidant involved in redox homeostasis, immune response, and metabolic processes. The development of low-cost high accurate electrochemical sensors is critical to overcome conventional glass carbon electrodes (GCE). In this report, we report the f...

Patient-centered limb preservation in giant recurrent myxofibrosarcoma: a case-based review of goal-concordant care

Myxofibrosarcoma is an infiltrative soft-tissue sarcoma of the elderly with a high propensity for local recurrence; giant, recurrent, infected tumors with sciatic nerve encasement may prompt consideration of amputation when adequate resection is expected to leave a non-functional...

Continuous lactate-driven biohydrogen production from the organic fraction of municipal solid waste

The organic fraction of municipal solid waste (OFMSW) is a promising feedstock for biohydrogen production via dark fermentation. Lactate-driven dark fermentation (LD-DF) mitigates the impact of lactic acid bacteria (LAB) overgrowth, yet its application under continuous operation...

Peptide language pragmatic analysis and two-stage hierarchical learning framework for therapeutic peptide prediction

Therapeutic peptides exert pivotal effects in diverse biological processes, and have attracted significant interest in the field of biomedicine in recent years. However, most existing methods often fail to adequately capture the intricate interactions among amino acid residues an...

Development and quality evaluation of apple-enriched fermented whey beverage from dairy whey

Six fermented apple-whey beverage formulations were initially evaluated sensorially for formulation selection. The formulation containing 60% fermented whey and 40% apple concentrate was selected for further characterization and storage studies. The selected formulation was inocu...

Do elite soccer players meet nutritional requirements? A scoping review and meta-analysis

This scoping review and meta-analysis synthesised current evidence on energy and macronutrient intake and energy expenditure in elite male and female soccer players. Despite established nutritional guidelines, concerns persist regarding chronic low energy availability and its imp...

The Qualia Tomogram: A Generalized Projection-Slice Framework for Receiver-Conditioned Neural Reconstruction

The Qualia Tomogram develops a falsifiable projection-slice framework for studying how partial, receiver-conditioned neural measurements could support a shared, body-relative reconstruction. It connects the Self Aware Networks concepts of tonic context, Phase-Wave Differentials,...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Platform ecosystem governance and its influence on the process of formation and institutionalization of new practices for development

This study examined how platform ecosystem governance mechanisms, as enacted through human intermediaries, influenced the formation and institutionalization of new practices among smallholder farmers in an ICT4D context. We conceptualize platform ecosystems as socio-technical sys...

Net-Zero Strategy Credibility and Firm Valuation in Middle Eastern Equity Markets

Corporate net-zero pledges have proliferated across the Middle East, yet whether capital markets distinguish credible decarbonization strategies from symbolic ones remains unexamined in energy-exporting emerging markets, a gap this study addresses. This omission matters because t...

A Constant-Competitive Algorithm for Dynamic Mixture-of-Experts Serving

Huang, Lou, and Xiao introduced Dynamic Mixture-of-Experts Serving and gave an O(sqrt(log k))-competitive randomized algorithm for the integral primal, leaving the primal order open. This preprint proves that the randomized primal competitive ratio is Theta(1) for arbitrary numbe...

Conormal problem for a kind of nonlinear elliptic equations

Abstract We study the global boundedness of weak solutions to a class of nonlinear elliptic equations in bounded Lipschitz domains, subject to conormal boundary conditions. Using techniques from Morrey space theory, Adams-Maz’ya trace inequalities, and higher integrability proper...

Strain-Induced Modification of Landau Levels and Quantum Oscillations in Semiconductor Quantum Wells

In this article, the effect of deformation on the Landau levels of electrons and holes in quantum semiconductors is considered. The effect of deformation on the temperature dependence of quantum oscillation effects in small-sized semiconductors obeying the quadratic dispersion la...

Every Convex Polyhedron with Directly Congruent Scalene Triangular Faces Is a Tetrahedron

Let T be an oriented scalene Euclidean triangle. We prove that every convex polyhedron whose outward-oriented facets are directly congruent to T is a disphenoid tetrahedron. Consequently, such a polyhedron exists if and only if T is acute; in particular, right and obtuse scalene...

More than just temperature: the effects of nest relocation on incubation environment and hatchling quality in green turtles (Chelonia mydas)

Abstract Nest relocation and shading are widely used conservation strategies intended to mitigate threats to marine turtle hatchling survival. However, these interventions may carry unintended fitness costs. Estimating such effects can be challenging, especially in the absence of...

The Paradox Docket: A Computable Classification of the Classical Paradoxes

For twenty-three centuries the word "paradox" has been handed out without an audit: it is worn by genuine logical dead ends, by harmless puzzles, and by plainly ill-posed questions. We conducted the audit. The classical collection — the liar and its family, Russell, Curry, Yablo,...

Localized Spatio-Temporal Dynamics of Sustainable Urban Built Morphology

Evaluating Sustainable Urban Built Morphology (SUBM) patterns at a metropolitan-wide scale obscures the localized trends in urban morphology across space and time. This research introduces Development Morphology Units (DMUs) as a micro-scale analytical concept for investigating t...