Research works

Infectious complications following bispecific antibody or CAR T therapy in adult patients with hematologic malignancies: a retrospective database analysis

T-cell redirection therapies, including bispecific antibodies (BsAbs) and chimeric antigen receptor (CAR) T therapy, have transformed the treatment of relapsed or refractory hematologic malignancies. However, comparative data on infectious complications between these treatments r...

Volcano–climate interactions: reframing the volcano–climate puzzle

Explosive volcanic eruptions are major natural perturbations of the Earth system. By increasing stratospheric aerosol loading, they exert a dual radiative forcing: enhanced scattering of incoming solar radiation induces global surface cooling, while absorption of terrestrial radi...

Tailored novel nanocomposites for advanced elimination of methylene blue dye from water

Novel SrCO 3 /CuO/MgO/C (Abbreviated as CSM600) and SrCO 3 /CuO/MgO/Sr 2 CuO 2 CO 3 /Cu 2 SrO 3 /SrCuO 2 /C (Abbreviated as CSM800) multiphase nanocomposites were successfully synthesized through a Pechini sol–gel route followed by calcination at 600 and 800 °C. Structural analys...

Experimental methodology for evaluating enzyme kinetics and biocatalytic activity of antioxidant systems in pigmented Ficus leaves exposed to green-synthesized silver nanoparticles

Plant-derived biomaterials provide a sustainable platform for the development of functional nanostructures and biocatalytic systems. In this study, the kinetic properties and biocatalytic efficiency of catalase (CAT), peroxidase (POD), and polyphenol oxidase (PPO) were evaluated...

High-fidelity animal model simulation improves surgical competence in medical students

To determine whether a formal suturing simulation course using a realistic animal model improves medical students’ perception of their technical competence and their later self-confidence in a competency-based model of surgical education. The opportunities to acquire hands-on tra...

Binary Projections: How the Self-Inspection Mechanism of the Cosmic Living Organism Expands into Human Entire Cognitive System

Yuanxian Theory establishes four cosmic meta-laws—Cosmic Organism Law (COL), Dichotomous Cognition Law (DCL), Hexagonal Closure Law (HCL), Minimum Energy Manifestation Law (MEL)—as the foundation of all derivations, with Dichotomous Cognition Law (DCL) at the core: cosmic self-in...

BAM: A physics-informed self-supervised framework for near-real-time wildfire burned area mapping from multi-source earth observation

The operational monitoring of global wildfires is frequently constrained by the delayed availability of reliable reference labels, the latency of standard surface reflectance products, and spectral confusion between charred biomass and naturally dark surfaces. These limitations a...

Modular reconfigurable underwater robot (MRUR): a comprehensive review of structure, perception, and control

Modular reconfigurable underwater robots (MRURs) have attracted increasing attention due to their potential to overcome the limitations of conventional underwater robots with fixed structures and single-task capabilities. This review summarizes recent progress in MRUR from three...

Undecidability Does Not Kill Simulation: Provability, Execution, and the Missing Premise in Anti-Simulation Arguments

Arguments based on Gödel incompleteness and undecidable questions in physics are sometimes presented as proofs that the universe cannot be simulated. This paper reconstructs that argument in its strongest form and identifies a missing premise. Generating a process one step at a t...

PIGU expression is associated with poor prognosis and estimated immune cell infiltration in breast invasive carcinoma

Breast invasive carcinoma (BRCA) is a major cause of cancer-related mortality in women. PIGU , a subunit of the GPI-anchor biosynthesis complex, has been reported to be dysregulated in several cancers; however, its prognostic value and immune-related associations in BRCA remain u...

Analysis of birefringence modulation performance in RM-embedded CO-polymer waveguides

Uncontrolled birefringence causes measurement errors and signal distortion in high-precision optical systems, yet existing modulation methods suffer from complex fabrication or poor stability. Polymer waveguides serve as low-cost, flexible alternatives to traditional lithium niob...

Improving Generative Deep Learning-Based SAR-to-Optical Image Translation through Spatiotemporal Feature Incorporation: A Case Study in Cropland

Synthetic aperture radar (SAR)-to-optical (S2O) image translation is an effective approach for reconstructing cloud-contaminated regions in optical imagery using corresponding SAR observations.However, its ability to reconstruct multispectral optical information is inherently lim...

Association between remnant cholesterol inflammatory index and new-onset stroke in different glycemic metabolic states: insights from the China health and retirement longitudinal study

The remnant cholesterol inflammatory index (RCII) has been proposed as a novel biomarker for lipid dysregulation and inflammation, and has also been suggested as a potential risk factor for diabetes. However, the association between RCII and the incidence of new-onset stroke acro...

A kirigami-inspired soft gripper based on liquid crystal elastomer integrated with strain sensing

Soft robotic grippers are capable of handling objects with diverse shapes and sizes. However, achieving reliable grasping of delicate objects and sustaining prolonged holding with minimal energy input remains challenging. This study reports a miniaturized liquid crystal elastomer...

A seven-gene signature diagnostic model for early-onset colorectal cancer and the tumor-suppressive role of SLC26A2 via redox modulation

The rising incidence and poor prognosis of early-onset colorectal cancer (EOCRC) highlight an urgent need for effective diagnostic biomarkers. This study integrates RNA sequencing data with machine learning algorithms to identify EOCRC-specific genes and construct a diagnostic mo...

Standardized lake fish community assessment using modified multi-mesh gillnets to minimize fish mortality

Systems for assessing the ecological status of lakes with respect to fish population are normally based on catches using conventional European Committee for Standardization (CEN) gill nets. A modified gillnet (MOD) design with less small-mesh and more large-mesh panel area , deve...

Nodular fasciitis of the nasal cavity with USP6 rearrangement: a case report

Nodular fasciitis (NF) is a benign myofibroblastic tumor characterized by rapid growth, self-limiting course, and rearrangement of the USP6 gene. While NF can occur in the head and neck region, cases originating within the nasal cavity are exceedingly rare. We herein report a cas...

Integrative multi-omics analysis identifies SMIM24 as a favorable prognostic biomarker in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) exhibits substantial molecular and clinical heterogeneity, contributing to variable disease progression and therapeutic outcomes. We previously identified a de-clear cell differentiation (DCCD) tumor state characterized by loss of canonical...

Cascading effect of early sensory differences on subsequent autistic traits in infants later diagnosed with autism: a prospective cohort study

Sensory differences constitute core diagnostic features of autism. The cascading effect model posits that early sensory differences may be prospectively associated with subsequent autistic traits, whereas empirical evidence in infancy remains scarce. This study aims to characteri...

A clinically translatable coating-free strategy for 3D-printed porous titanium implants: TiO2 nanotubes simultaneously prevent infection and promote bone integration

Orthopedic implants face persistent clinical challenges of peri-implant infection and impaired osseointegration, especially in high-risk populations with trauma, osteoporosis, or diabetes. Herein, we report a coating-free strategy integrating three-dimensional (3D) printing and e...