Research works

Key management practices controlling yield performance and nitrate leaching in a grass-clover based organic crop rotation

Organic farming is frequently discussed as a strategy for mitigating nitrate leaching, especially in water protection areas. The effectiveness of nitrogen (N) management practices within organic crop rotations requires evaluation to balance yield performance with nitrate leaching...

Pre-treatment serum bicarbonate predicts survival in patients with locally advanced esophageal squamous cell carcinoma undergoing definitive radiotherapy: a retrospective propensity score matching study

This study aimed to evaluate the prognostic value of pre-treatment serum bicarbonate (HCO 3 − ) for overall survival (OS) and progression-free survival (PFS) in locally advanced esophageal squamous cell carcinoma (LA-ESCC) patients undergoing definitive radiotherapy. Patients wit...

Psychological profiles of readiness for advance care planning in super-aged Japan

Advance care planning (ACP) helps ensure that future medical care reflects individuals’ values and preferences. However, little is known about how multiple psychological characteristics combine to shape readiness for ACP, particularly in Japan. This study aimed to identify psycho...

A spatiotemporal attentive recurrent neural network for robust RSS based indoor localization

Indoor localization remains challenging in GPS-denied environments due to weak signal reception and non-line-of-sight conditions. Among various techniques, WLAN Fingerprinting using Received Signal Strength (RSS) has emerged as a cost-effective solution that leverages the widespr...

Toeplitz-structured deep unfolding network for TomoSAR 3-D reconstruction

Urban area 3-D imaging is a key application of synthetic aperture radar (SAR). Classical compressive sensing-based tomographic SAR methods rely on iterative optimization, which is computationally expensive and sensitive to hyperparameter tuning, limiting its scalability for large...

Real-world genomic landscape of FGFR2 amplifications and fusions in solid tumors: analysis of 4,953 patients using clinical-grade NGS

Fibroblast growth factor receptor 2 (FGFR2) alterations, including amplifications and fusions, are actionable oncogenic drivers in multiple cancers, but their prevalence and genomic features are not well defined. Between October 2019 and October 2024 at Samsung Medical Center, 4,...

Longitudinal metagenomic profiling of gut microbiome dynamics in B-cell lymphoma patients receiving CAR-T cell therapy

Chimeric antigen receptor T-cell (CAR-T) therapy has improved outcomes in B-cell malignancies, but treatment response and immune-related toxicities remain heterogeneous. We characterized peri-infusion gut microbiome dynamics and examined their associations with subsequent respons...

Deep Learning-Based Temporal Gait Analysis Using a Smartphone IMU in Older Adults with and Without Non-Specific Low Back Pain

Accurate gait event detection using inertial measurement units (IMUs) is essential for temporal gait analysis, but frame-level detection is challenged by sparse initial contact (IC) and foot-off (FO) events. This study evaluated recurrent neural network architectures and training...

Wholly bio-based hyperbranched waterborne polyurethane coatings reinforced with surface-engineered cellulose nanofibers for sustainable wood protection

Bio-based waterborne polyurethane (BWPU) coatings have drawn attention as renewable alternatives to petroleum-based wood finishes for Larix gmelinii , yet their mechanical strength, hardness, and barrier properties remain insufficient for demanding applications. In this work, cel...

Opportunities for pathways approaches for adapting to complex climate change risks

Adaptation planning is increasingly challenged under conditions of complex climate change risks, which are characterized by the dynamic interactions between compounding hazards, cascading impacts, governance failures, and multiple drivers of vulnerabilities, producing non-linear...

Effectiveness of telehealth-based cardiac rehabilitation in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis

Telehealth-based cardiac rehabilitation programs have emerged as a promising alternative to traditional center-based rehabilitation, offering improved accessibility and convenience for patients undergoing percutaneous coronary intervention (PCI). This review aimed to evaluate the...

Engineering SIM-1 and MZ-1 PROTACs for enhanced target degradation in KSHV-infected immortalized endothelial cells

Kaposi’s Sarcoma-associated Herpesvirus (KSHV) is the etiologic agent of several human cancers, including Kaposi’s Sarcoma (KS), which are still lacking of treatment options. Members of the bromodomain and extra-terminal domain (BET) family, especially bromodomain-containing prot...

A bioethics-informed public health imperative for surrogacy regulation in Africa

Surrogacy is a highly debated method mainly used for treating women with infertility caused by uterine factors. This systematic review summarizes current levels of knowledge of the obstetric, medical and psychological outcomes for the surrogate mothers, the intended parents and c...

EBV-driven Gate–License–Amplify circuit in multiple sclerosis pathogenesis

Five recent publications establish a “Gate–License–Amplify” circuit that mechanistically links Epstein–Barr virus (EBV) infection and genetic risk (HLA-DR15) to the pathogenesis of multiple sclerosis (MS). 1 , 2 , 3 , 4 , 5 This new model reveals how EBV reprograms immunopeptidom...

Innovative development of an advanced machine learning modeling for predicting compressive strength of graphene-infused concrete: a SHAP and PDP approach

The quasi-brittle response of cementitious materials continues to limit their structural efficiency, necessitating advanced reinforcement strategies. While conventional fibers improve mechanical performance, the emergence of graphene-based nanomaterials offers new opportunities t...

A diffusion-based multi-style image generation framework with adaptive weighted style fusion

Diffusion-based multi-style image generation aims to preserve the semantic structure of a content image while integrating visual characteristics from multiple style references. Existing style transfer and diffusion-based methods often rely on single-style guidance, fixed prompts,...

One Bit of Difference: Moments of Frame Triples in the Albert Algebra

Three frames mark the threshold of exceptional generation in the Albert algebra J = H₃(𝕆): any two Euclidean frames generate only a special subalgebra, while an exact triple can generate all of J. For a generic ordered, labelled triple, however, the pairwise overlaps and triple e...

Severe congenital four-limb reduction defect with bilateral humeroradial synostosis and Pierre Robin sequence in a low-resource setting: a case report and differential-diagnostic approach from Burkina Faso

Severe limb reduction defects are rare congenital malformations that remain poorly documented in sub-Saharan Africa. When all four limbs are severely affected, the resulting phenotype is aetiologically heterogeneous and overlaps several monogenic syndromes — including the femoral...

Machine learning–driven structural health monitoring of a high-rise building on thick sediments via seismic ambient noise

Seismic ambient noise enables non-invasive monitoring of high-rise buildings, but existing indicators trade floor-level localization for operational simplicity. Resonance-frequency changes track whole-building stiffness but poorly localize structural variations, whereas inter-flo...

Optimal control strategies for dengue transmission under varying adult prevalence of Wolbachia -carrying mosquitoes: a deterministic mathematical modeling study

Objectives: This study aimed to develop prevalence-informed post-release dengue control strategies for settings in which Wolbachia-carrying Aedes aegypti mosquitoes have become established through population replacement and to quantify how optimal supplementary intervention inten...