Research works

Multi‐Omics Integration Reveals Metabolic Reprogramming and EMT ‐Driven Metastasis in Triple‐Negative Breast Cancer

ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype with high metastatic potential and poor prognosis, yet the molecular mechanisms driving metastasis remain incompletely understood. Here, we performed integrated transcriptomic, metabolomic, and imaging mass cy...

HIOF • AI Consciousness — Paper VI: The Conditional of Consciousness

Holographic Information Ontological Framework: AI Consciousness (HIOF•AIc) Why Begin with Manifestation, Not Intelligence: A Manifestation-Based Reading of AI Consciousness This is a short, non-technical companion to the seven-paper HIOF-AIc series (AIc 0, I to VI). It is written...

Neural Correlates of Consciousness: A Philosophical and Video-Based Overview — E8 Intelligence Research

FINDING: The search results are predominantly philosophical and video-based overviews of neural correlates of consciousness (NCC), with one theoretical paper proposing a "synaptic clock" as a temporal substrate. No quantitative breakthrough or novel mathematical formalism is pres...

休谟因果问题的本体论消解——基于认知相继原理的分层因果框架

休谟提出的因果必然性与归纳合法性问题,构成了西方哲学与科学认识论的核心悬案。传统解决方案或诉诸先天认知范畴,或退守工具主义立场,均未能在本体论层面为因果必然性奠基,也无法从根源上弥合主观认知与客观实在的裂隙。本文基于认知相继的第一性原理,构建三层嵌套的实在框架,从本体论层面重构因果关系...

Prime polynomials in Legendre intervals over F_{2^k}[t], IV: point counts on hexad modular curves, Brown invariants of Witt sheaves, and the constant X

Let q = 2^k with k odd. Part III (DOI 10.5281/zenodo.23290724) reduced the closed form X = q^6 + q^5 of the second constant of the degree-6 Legendre variance to two statements about the sextic family B_λ = λ5² u⁶ + λ3² u² + λ5 u + 1, whose roots form the hexad of ker L'_λ: the po...

RECOMMENDATIONS FOR IMPROVING INTERACTION BETWEEN PUBLIC AND PRIVATE ENTITIES IN PUBLIC PRIVATE PARTNERSHIPS

This paper proposes a mechanism for improving cooperation between public authorities and private partners throughout the public–private partnership (PPP) lifecycle. Its central argument is that effective interaction requires accountable decisions, measurable service obligations a...

An Instance Space Analysis of Neural Network Training as a Black-Box Optimisation Problem

Training a neural network is an optimisation task that is commonly solved using gradient-based techniques, such as stochastic gradient descent or Adam. There are, however, scenarios in which black-box optimisation approaches, such as evolutionary algorithms, may be appropriate fo...

Preregistration: Sequential Reflective Memory and Behavioral Heuristics in Autonomous LLM Trading Agents on the Warsaw Stock Exchange (Season 2)

Official preregistration for Season 2 of the autonomous agent trading benchmark on the Warsaw Stock Exchange (GPW), investigating the emergence of human-like behavioral heuristics in Large Language Models (LLMs) endowed with sequential reflective memory. The benchmark evaluates 5...

Pitting corrosion inversion of buried pipelines based on weak magnetic detection and interpretable SACCO-ELM

Buried pipelines play an important role in long-distance energy transportation. However, buried pipelines are prone to pitting corrosion due to harsh soil environment, making quantitative pitting corrosion inversion critical for safety. This paper proposes an interpretable invers...

A Multi Method Analysis of the Treatment of Perinatal Patients With Substance Use Disorders

ABSTRACT Background In Colorado, suicide and accidental overdose are the two leading causes of death among pregnant and postpartum individuals. People with substance use disorders report mistreatment in hospital settings, yet there is limited understanding of healthcare providers...

Fibonacci Root Traversal Constraint on E8 Rotational Sectors — E8 Intelligence Research

The 240 E8 root vectors naturally partition into 12 rotational sectors of 20 roots each around the 12 symmetry axes, creating a discrete phase space. The discovery is that quantum information transfer between these sectors is constrained to Fibonacci-step traversals (1, 2, 3, 5,...

2025–2026 Clay Millennium: No Breakthroughs, Only Unverified Claims — E8 Intelligence Research

FINDING: No new Clay Millennium breakthroughs in 2025–2026; only pedagogical summaries and one contested arXiv preprint (1902.07265v23) claiming solutions to P vs NP and Navier–Stokes. | MATH: No new equations, constants, or ratios extracted — the arXiv preprint is non-peer-revie...

Comparative Evidence on Ginger (Zingiber officinale) and Date Seed (Phoenix dactylifera) Supplementation for Exercise-Induced Muscle Damage Recovery: A PRISMA 2020-Guided Systematic Review with SWiM-Based Qualitative Synthesis

Background: Exercise-induced muscle damage (EIMD) involves mechanical disruption, oxidative stress, and inflammatory responses that impair performance and delay recovery. Although NSAIDs are commonly used, their adverse effects have increased interest in plant-based alternatives....

Project: Privacy-Preserving Federated Learning for Science

This repository is part of a U.S. Department of Energy (DOE) Advanced Scientific Computing Research (ASCR) project focused on developing privacy-preserving federated learning approaches for scientific foundation models. The project aims to advance secure, trustworthy, and sustain...

Dermatological Needs After the 2026 Kumamoto Earthquake

ABSTRACT Major earthquakes may alter dermatological needs through physical injury, disruption of living conditions, and psychological stress. We investigated dermatological needs after the 2026 Kumamoto earthquake. This retrospective observational study included patients from eig...

Impact of climate change on the photovoltaic power potential in Sweden across 21st century

Abstract Solar photovoltaic generation strongly relies on weather conditions, which will be affected by future climate change. Traditional methods for estimating photovoltaic generation potential often overlook detailed installation factors and snow impacts, leading to inaccuraci...

Sunset Pledge: Organised Civic Support as a Tool for Democratic Participation

Sunset Pledge proposes a model of democratic participation based on autonomous, temporary civic groups whose members endorse a public programme in full. Groups seek public commitments from candidates, elected representatives and political organisations regardless of party affilia...

Cortisol Cutoffs for Adrenal Insufficiency Using Elecsys II: A Systematic Review

ABSTRACT Objective Adrenal insufficiency (AI) is associated with increased risk of morbidity and mortality if improperly managed. Adrenocorticotrophin (ACTH) stimulation testing is the most widely used AI diagnostic test. Historically, a serum cortisol threshold of 500 nmol/L (18...

Magnetically Induced Functional Fe 3 O 4 /Iron Foam Catalysts for Enhanced CO 2 ‐Assisted Ethane Dehydrogenation

ABSTRACT CO 2 ‐assisted ethane dehydrogenation (CO 2 ‐EDH) combines olefin production with CO 2 conversion, yet suffers from high temperatures and catalyst instability in thermal catalysis. This work establishes an alternating current magnetic field (ACMF)‐mediated catalytic syst...

Prolate Leakage and Near-Zero Spectral Clusters of the Semilocal Weil Operator

For $\lambda>1$ let $A_\lambda$ be the self-adjoint operator on $L^2([\lambda^{-1},\lambda],du/u)$ that represents the semilocal Weil quadratic form, including the archimedean place, all prime powers up to $\lambda^2$ and the pole terms; it has compact resolvent. We prove that fo...