Research works

Salivary telomere length in oral leukoplakia and oral squamous cell carcinoma: A preliminary case- control study

Purpose To evaluate salivary telomere length as a potential non-invasive exploratory biomarker for early molecular alterations associated with oral leukoplakia and oral squamous cell carcinoma. Methods Forty-five participants were initially recruited: 15 healthy controls, 15 leuk...

Thermofluid Performance Analysis of a Plate Heat Exchanger for EV Heat Pump Systems Using PFAS-Regulation-Compliant Refrigerants

본 연구는 강화되는 PFAS 환경 규제에 선제적으로 대응하기 위해, 친환경 냉매 R744를 적용한 전기자동차용 히트펌프 시스템 내 판형열교환기의 열유동 성능을 3차원 CFD 해석을 통해 규명하였다. 쉐브론 패턴이 적용된 판형 열교환기를 포함한 3차원 모델을 구축하고, k-ω SST 난류 모델을 적용하여...

Chikungunya fever among Japanese travelers: monthly and yearly trends in imported cases, 2011–2023

Objectives: Chikungunya poses an increasing threat to people living in endemic areas and to travelers from non-endemic regions. This study descriptively characterized imported chikungunya cases in Japan and explored the relationship between local incidence in destination areas an...

Do ESG indices offer resilience to geopolitical shocks? Evidence from contagion between DAX and emerging markets during the Russia-Ukraine War

The rapid growth of environmental, social, and governance (ESG) investment products, perceived as representing responsible businesses, has made it imperative for investors to assess their effectiveness in insulating portfolios from geopolitical shocks. The current study investiga...

Programmable ZBTB7A RNA N6-methyladenosine site-specific demethylation suppresses colorectal cancer liver metastasis

Colorectal cancer liver metastasis (CRLM) is the primary cause of CRC-related mortality, with inevitable chemoresistance to targeted therapies and immunotherapy. N 6 -methyladenosine (m 6 A), as a crucial epigenetic regulator of gene expression and cellular physiology, involved i...

Optimized technique for experimental multivisceral transplantation

Background There has been a shift toward combined liver-intestine and multivisceral transplantation (MVT), whereas isolated intestinal transplantation has taken a backseat, mainly because of its higher rejection rates. Despite this, experimental models tend to focus on intestinal...

Rotational canal scheduling in two oasis irrigation districts using a weighted composite objective and a sigmoid-adaptive genetic algorithm

Rotational canal scheduling in arid irrigation districts must satisfy coupled water-volume, timing, and hydraulic constraints while balancing modeled seepage loss and the dispersion of trunk-canal discharge levels. A constrained model with a weighted composite objective was solve...

Evaluating effect of implementing Gibbs’ reflective model on quality of nurses’ documentation in emergency departments: a clinical trial

Emergency nurses are responsible for providing and documenting immediate patient care. Documentation is a fundamental component of their professional practice; however, evidence indicates that documentation standards are often not adequately met. Therefore, innovative training ap...

Targeted biologics in muscle strength restoration and corticosteroid sparing for patients post-myasthenic crisis

Myasthenic crisis (MC) represents a life-threatening condition in patients with myasthenia gravis (MG). Despite a substantial reduction in in-hospital mortality for MC, full restoration of muscle strength and quality of life usually requires months or years. It remains unknown wh...

Authentic and Sustained Family Partnership in Neonatal and Pediatric Research

Improving the health and well-being of children requires sustained partnerships with parents, community members, advocates, and researchers to identify and answer high-impact research questions. Meaningful engagement with families and communities in the design, conduct, and disse...

The ZmmiR169o/ZmNF-YA13 module orchestrates maize kernel texture by fine-tuning starch biosynthesis and endosperm architecture

BACKGROUND: Kernel texture is a key agronomic trait determining grain quality and storage stability in maize. The ratio of vitreous endosperm is the principal metric for kernel texture, and elucidating the key genes governing its formation is vital for maize breeding. Although mi...

Alfalfa-winter wheat rotations stabilize yields and maintain soil water sustainability under precipitation variability

Global climate change caused variation in precipitation patterns has become a threat for food security, especially for semi-arid rainfed farming system, i.e., the Loess Plateau. Whether short-term alfalfa-winter wheat rotations could serve as sustainable alternatives to winter wh...

Access and excess as interacting drivers of antimicrobial resistance in low and middle income countries

Antimicrobial resistance (AMR) disproportionately affects low- and middle-income countries (LMICs). However, dominant stewardship frameworks often emphasize overuse, underrecognizing the access–excess dynamic: inadequate access to effective antimicrobials coexisting with inapprop...

Resource-constrained valorization of lignocellulosic agricultural and forest residues for sustainable aviation fuel production: An integrated techno-economic and life cycle assessment

Aviation is a hard-to-abate sector due to its reliance on high energy density liquid fuels, making sustainable aviation fuel (SAF) a key decarbonization option. However, large-scale deployment of SAF is constrained by limited feedstock availability and high production costs. Exis...

Comparative analysis of associations between facility structure and air quality managers’ knowledge, attitudes, and practices by COVID-19 outbreak status in welfare facilities for persons with disabilities: a cross-sectional survey study in South Korea

Objectives: This study investigated associations between building structure and managers' knowledge, attitudes, and practices (KAP) regarding indoor air quality in welfare facilities for persons with disabilities, comparing facilities with and without coronavirus disease 2019 (CO...

Health needs assessment of women with spinal cord injury in Greece: a qualitative study

Women with spinal cord injuries (SCI) are a group with multiple unmet health needs, typically neglected in research and policy development. This study employs a participatory design approach. Three focus groups for in-depth, qualitative interviews were conducted to explore the he...

Prevalence of dementia and BPSD in community-dwelling older adults with advanced care needs: a nationwide survey in Taiwan

Background Caring for people with both dementia and advanced care needs is complex. This study aimed to elucidate the prevalence of dementia and behavioral and psychological symptoms of dementia (BPSD) in patients receiving advanced care, including tube feeding, respiratory care,...

Vision-Language Model as a ‘Zero-Shot’ Assistant for Evaluating Condylar Osseous Changes in Cone-beam Computed Tomography

INTRODUCTION AND AIMS: Interpreting condylar osseous changes on CBCT is challenging for general practitioners. This study evaluated the 'zero-shot' diagnostic performance and utility of Vision-Language Models (VLMs) as AI assistants for detecting condylar abnormalities. METHODS:...

Endothelial cell-microglia crosstalk mediates heart failure-associated synaptic loss and cognitive impairment in male mice

Cognitive impairment affects 30%–80% of patients with heart failure, yet the mechanisms beyond reduced brain blood flow remain poorly defined. Here we show that circulating factors released during heart failure trigger senescence of brain blood-vessel endothelial cells, which in...

Quantitative analysis of dental prostheses materials on the magnitude of artefacts at different positions in cone-beam computed tomography: an ex vivo study

To evaluate the effect of crown materials for fixed prostheses on the image quality at different positions in Cone-Beam Computed Tomography (CBCT). A customized virtual maxillary model with three fixed abutments and six recesses was designed and fabricated using 3D printing. Six...