Research works

Visual and rapid detection of Fasciola spp. in fecal samples using a one-pot RPA-CRISPR/Cas12a assay

Fasciolosis caused by Fasciola spp. has substantial veterinary and public-health importance, while conventional fecal microscopy has limited sensitivity and PCR depends on laboratory equipment. This study aimed to develop a rapid, visual one-pot recombinase polymerase amplificati...

Evaluating Immunotherapy Outcomes in Elderly Patients with Extensive-Stage Small-Cell Lung Cancer (KCSG LU23-15)

PurposeChemoimmunotherapy has improved outcomes in extensive-stage small-cell lung cancer (ES-SCLC), but its benefit in older adults remains uncertain because this population is underrepresented in clinical trials.We evaluated the real-world efficacy of first-line atezolizumab pl...

Computational investigation of the antibacterial and antioxidant potential of Rosa damascena essential oil from Morocco: Molecular docking and ADMET analysis of fourteen volatile compounds

The emergence of multidrug-resistant bacterial strains has intensified the search for novel plant-derived antimicrobial agents. The present study reports the first comprehensive in silico investigation of the major volatile constituents of Rosa damascena Mill. essential oil (RDEO...

Demographic and psychosocial factors associated with adjustment and reintegration to civilian life: a prospective and cross-sectional analysis of transitioning and ex-serving military personnel

The prevalence of reintegration and adjustment difficulties among military veterans transitioning to civilian life is high, with maladjustment linked to poor mental health and increased suicide risk. Identifying factors predictive of adjustment may inform the development of preve...

Patterns and perceptions of supplement use among patients with plasma cell disorders

As novel treatments have improved survival in patients with plasma cell disorders (PCDs), there is a growing interest in complementary medicine (CM), particularly dietary supplements (vitamins, minerals, antioxidants, and herbs), amongst patients with cancer [ 1 ]. Multiple myelo...

Physical activity from bus travel: objective estimates linking accelerometer and travel card data

Background Low physical activity contributes to chronic disease and premature death. Public transport can integrate activity into daily routines, but robust methods are needed to estimate physical activity during public transport trips. This study quantified duration, intensity,...

The impact of digital transformation on urban green and low-carbon transformation efficiency: evidence from a double machine learning approach

This study selected 279 Chinese cities as research samples and integrated double machine learning models, Gini coefficients, and standard deviation ellipses to systematically analyze the dynamic evolution of urban green and low-carbon transformation efficiency amid digital transf...

Research Updates

to Terms with the Holocaust: Appearances and Truths in Germany.

Optimizing the Structural Integrity of Gwapyeon with Red Bull Ⓡ and Enhancing Consumer Acceptability: A Comparison of Corn, Mung Bean, and Potato Starch

Gwapyeon, a traditional Korean fruit starch-based gel, offers a unique matrix for functional food diversification.This study investigated the technical feasibility of incorporating a commercial energy beverage (Red Bull Ⓡ ) into a gwapyeon system and evaluated how the source and...

Sialic acid-binding immunoglobulin-like lectin-6 (SIGLEC6) is increased by hypoxia and inflammation in trophoblasts

Objectives SIGLEC6, a human-specific transmembrane receptor, is highly expressed in placenta. SIGLEC6 is elevated in maternal circulation preceding preeclampsia and in women with preeclampsia, correlating with disease severity. This study aimed to investigate the regulatory mecha...

Comment on the paper “Optimization of heat transfer on Jeffrey ternary nanofluid flow with slip conditions and heat generation by response surface methodology, Shahirah Abu Bakar, Nur Syahirah Wahid, Norihan Md Arifin, Ioan Pop, Multiscale and Multidisciplinary Modeling, Experiments and Design (2025) 8:150”

Many serious errors exist in the above paper.

Incidence and predictors of peripheral intravenous cannula complications among pediatric patients in public hospitals of Gurage zone, Ethiopia: a multicenter prospective cohort study

Peripheral intravenous cannulas are used for administration of medications and fluids in sick children but their use can result in complications. The main aim of this study was to determine the incidence of complications and predictors with peripheral intravenous cannula use in P...

Long-term outcomes of first episode affective psychosis in postpartum women

BACKGROUND: Outcomes of first episode postpartum psychosis and their distinction from outcomes of non-postpartum psychosis are poorly characterised. AIMS: To characterise the disease course and outcomes of first episode postpartum psychosis, compared with first episode non-postpa...

Superselective Neck Dissection in Oral Squamous Cell Carcinoma: a Scoping Review.

In patients with cN0 oral squamous cell carcinoma, does superselective neck dissection provide equivalent oncological outcomes compared with selective neck dissection while reducing morbidity?

Sensor-Driven Situational Awareness for Disaster Responders

Disaster responders frequently operate in environments where information is incomplete, delayed, or inaccessible. This work presents an engineering framework for a distributed sensor system designed to enhance situational awareness for emergency personnel. Drawing on field experi...

Assessing reliability of BERT-based models on question answering tasks

Reliability estimation of large language models is in many cases as crucial as their accuracy, as reliable models are more trustworthy, robust, and suitable for practical applications. Recent advancements in natural language processing (NLP), particularly those based on transform...

Crystalline Information: Information as Ontological Structure

Information is ordinarily said to be in things: contained in books, carried by signals, stored in memories. This paper argues that the metaphor conceals a substantive error. In the ontological register — concerned not with how messages travel but with how a domain becomes articul...

Distributed Mechanistic Interpretability at Scale: Activation Streaming, Split-Layer Inference, and Distributed Sparse Autoencoder Training

ActStream: a two-node system that splits inference and analysis, streams intermediate activations over a binary wire protocol, and trains sparse autoencoders without staging activations to disk. Thunderbolt measured at 2.150 GB/s, 86% of negotiated rate and 26x the LAN path, with...

Efficient Mechanistic Circuit Analysis of Open-Weight LLMs on Apple Silicon

Replication and extension of the GPT-2 Small IOI circuit analysis on Llama-3.2-3B and Pythia-1.4B using an MLX activation-patching harness on a single Apple Silicon machine. Circuits are faithful on the standard single-template dataset (F=0.663 and 0.854) but collapse on a 15-tem...

TopK Sparse Autoencoders Across Three Model Architectures: Dictionary Collapse, Dense-Feature Degeneracy, and the Limits of Activation-Pattern Feature Matching

TopK SAEs trained at matched sparsity and dictionary size on Llama-3.2-3B, Mistral-7B-v0.3 and Qwen2.5-3B. Reports abrupt dictionary collapse with partial recovery, dense-feature degeneracy invalidating frequency-based feature selection, and a null cross-architecture matching res...