Research works

Urinary dysfunction following single-level lumbar fusion in men: A propensity-matched analysis of surgical approach

Background: Urinary dysfunction remains an underrecognized complication of spine surgery, despite its potential impact on postoperative quality of life. However, comparative data evaluating urinary outcomes by surgical approach among men undergoing single-level lumbar fusion rema...

Circulating anti-Ro/SSA-antibodies and risk of heart rate-corrected QT interval prolongation: a meta-analysis

Abstract Backgrounds Accumulating evidence indicates that anti-Ro/Sjögren’s syndrome-related antigen A(SSA)-antibodies, specifically the anti-Ro/SSA-52kD subtype, can promote heart rate-corrected QT interval(QTc) prolongation by inhibiting the hERG-K+ channel. However, the numero...

Combining H2O2-SupplyingIron Peroxide Nanoclusters with GSH-Depleting Gold Nanoclusters forEnhanced Chemodynamic Therapy via Amplification of Oxidative Stress

Abstract Chemodynamic therapy (CDT), which employs •OH generated by Fenton-type reactions to trigger cancer cell death, has received much attention in recent years. However, CDT efficacy is restricted by insufficient H2O2 levels and reactive oxygen species (ROS) consumption by an...

How Polymer ChainsRemember Their Crystalline Past:Simulations Uncover the Molecular Origin of Melt Memory

Abstract Melt memory in semicrystalline polymers is the remarkable ability of polymer chains to retain structural information from a prior crystalline state after being heated above the melting temperature. This phenomenon can induce extraordinary self-nucleation and strongly inf...

Lactate dehydrogenase-to-lymphocyte ratio predicts overall and progression-free survival among patients with advanced small-cell lung cancer receiving first-line chemoimmunotherapy

Platinum plus etoposide combined with programmed death-ligand 1 (PD-L1) inhibitors is the standard first-line therapy for patients with advanced small-cell lung cancer (SCLC). However, reliable prognostic biomarkers are yet to be identified. The lactate dehydrogenase-to-lymphocyt...

TogoPhosTAC as a delivery-ready platform for targeted protein dephosphorylation

Phosphorylation-targeting chimeras (PhosTACs) enable targeted protein dephosphorylation by recruiting phosphatases through induced proximity. However, the direct recruitment of phosphatase subunits or holoenzymes with small molecules remains challenging, as suitable ligands are s...

Dissociation Between Functional Performance and Structural Joint Damage Following Sertraline Treatment in Collagen-Induced Arthritis

Rheumatoid arthritis is a chronic inflammatory joint disease often accompanied by depressive symptoms, in which functional impairment does not always reflect the extent of structural joint damage. Sertraline, a selective serotonin reuptake inhibitor, may influence behavioural and...

A 20-cm redundant vas deferens loop during late orchidopexy: aberrant ductal anatomy as an intraoperative pitfall in a 17-year-old male

Introduction and importance: Cryptorchidism is one of the most common congenital anomalies of the male genitourinary tract. Anatomical variations of the spermatic cord structures, though underreported, may increase the risk of iatrogenic injury during orchidopexy. Case presentati...

EuroMillions Breakthrough Mining — 1813 Sources, 13635 Leads Extracted — E8 Intelligence Research

Mined 1813 lottery+quantum breakthroughs. Extracted 13635 leads across 13 categories. 11628 high-value leads found. Categories: {"CORRIDOR": 1137, "FORMULA": 980, "GEOMETRIC": 726, "FORWARD_ATTEMPT": 1190, "QUANTUM": 1405, "TIMING": 208, "CELESTIAL": 1066, "GEMATRIA": 1137, "CONS...

Prompt Injection as an Architecture-Specific Attack Surface: Comparing LLM-Based and Traditional ML Spam Classifiers Under Adversarial Conditions

Large language models are increasingly deployed for text classification tasks that were previously handled by supervised machine learning. How the two approaches compare under adversarial conditions has received limited systematic attention, particularly in side-by-side evaluatio...

Halogen Substitution as a “Chirality Editor” for Amplifying Spin‐Selective Transport in Lead‐Free Metal‐Halide Hybrids

ABSTRACT Lead‐free metal‐halide hybrids hold promise as flexible semiconductors for X‐ray detection, but their application is constrained by inefficient carrier transport. Here, we introduce halogen substitution on chiral molecular cations as a “chirality editor” to modulate the...

Geometric Exclusion of Smooth Solutions to Navier-Stokes Equations at Stationary Right-Angles under No-Slip Boundary Conditions in Lean 4

This paper presents a proof by contradiction demonstrating that smooth solutions to the three dimensional incompressible Navier-Stokes equations do not exist for all time. Our argument is a direct consequence of a specific no-slip boundary condition: a stationary right-angle corn...

The Limits of Comorbidity Indices in TAVI: How Aggregation Dilutes the Prognostic Power of Individual Biomarkers

Objective. Heart-team decisions in transcatheter aortic valve implantation (TAVI) lean on EuroSCORE II, yet the comorbidity burden that often drives the final choice is rarely scored. We tested a specific two-part hypothesis: whether formally quantifying comorbidity burden (via t...

Emergence of biosignatures on Earth and implications for life detection

Earth’s organic chemical evolution (OCE) from abiotic to prebiotic to biotic provides critical insights that may have implications for how we interpret observations made by life-detection planetary missions. To search for life on other worlds, astrobiologists seek biosignatures:...

Development of Machine Learning Models for Predicting the Fertilizer Suction Characteristics of an Asymmetric Venturi Injector

The fertilizer suction performance of Venturi injectors is jointly governed by fertilizer-solution properties and hydraulic boundary conditions, resulting in multivariable and potentially nonlinear responses that may be difficult to characterize using simplified empirical relatio...

Network pharmacology–based prediction of the multi-target mechanism of Simhanada Guggulu in rheumatoid arthritis: an in silico study

Background: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder characterised by persistent synovitis, progressive cartilage and subchondral bone destruction, functional disability and systemic complications. Current disease-modifying therapy has substantially...

TPS10 contributes to linalool emission in rice in response to brown planthopper infestation

Abstract BACKGROUND Terpenoids, a prominent class of herbivore‐induced plant volatiles, play a crucial role in plant responses to insect attacks. However, the precise ecological functions of individual terpene synthases in rice defense mechanisms remain unclear. RESULTS The level...

Aligning protein-generative models to experimental fitness with ProteinDPO

Abstract Biological generative models can predict biological functions without task-specific training data but often under-perform specialized models. This is due to a fundamental ‘alignment gap’, where the rules learned during unsupervised training are not related to the functio...

Role of Glycerol-3-Phosphate Dehydrogenase in the Development, Pathogenicity, and Glycerol Biosynthesis of Aspergillus flavus

Aspergillus flavus, a ubiquitous phytopathogen, produces mycotoxins, especially aflatoxin B1 (AFB1), and infects crops worldwide. Glycerol-3-phosphate dehydrogenase (G3PDH) is a key enzyme in the glycerol synthesis and metabolic pathway catalyzing the reversible conversion reacti...

Safety and antiviral activity of inhaled siRNA SNS812 for treatment of mild-to-moderate COVID-19: a phase 2 randomized trial

Abstract Background SARS-CoV-2 remains a global health threat because ongoing viral evolution and immune evasion reduce the effectiveness of existing therapies. SNS812 is an inhaled small interfering RNA targeting a highly conserved region of the viral RNA-dependent RNA polymeras...