Research works

Multi-target Therapy with Rituximab plus Mycophenolate Mofetil versus Rituximab Monotherapy in Systemic Sclerosis–Associated Interstitial Lung Disease

Objective To compare the effectiveness and safety of rituximab (RTX) plus mycophenolate mofetil (MMF) versus RTX monotherapy in patients with SSc-ILD. Methods We performed a retrospective comparative analysis among adults with radiologically confirmed SSc–ILD treated with rituxim...

Early Companion-Vector CORDIC Architecture for QRD-RLS Systolic Adaptive Beamforming: Evidence from Publications by Roger Guorong Hu, 1990–1994

This historical technical report reconstructs and documents early CORDIC-based QR-decomposition recursive least-squares (QRD-RLS) systolic architectures for adaptive beamforming developed and published by Roger Guorong Hu and collaborators between 1990 and 1994. The central docum...

Active gut microbiota resistome identified by metatranscriptomics and its contribution to antimicrobial resistance

Abstract The global health crisis of antimicrobial resistance (AMR) is compounded by gut microbiota, which acts as a reservoir for antibiotic-resistant genes (ARGs). While DNA-based metagenomics can identify the potential for resistance, the resistome, it cannot determine the ARG...

📣 PROMO READY #120 [IndieHackers] — E8 Intelligence live AI trading ecosystem — E8 Intelligence Research

📣 PROMO READY #120 [IndieHackers] — E8 Intelligence live AI trading ecosystem I spent 3 years building a trading bot that lost money faster than I could drink my morning coffee. Then I stumbled onto something weird: E8 sacred geometry — the same 248-dimensional structure physici...

Adoption Telemetry: Measuring Enterprise AI Adoption from Production Signals

We introduce adoption telemetry: a method for measuring enterprise AI adoption by computing change-management stage-progression directly from production usage signals. We contribute (1) a framework unifying pre-deployment evaluation gates, production telemetry, and change-managem...

Realization of unconventional staircase topological Anderson phase transitions

Topological Anderson insulators provide a paradigm for disorder-induced topology, in which the underlying system turns from a trivial to a topological phase. It is widely recognized that the latter disappears at large disorder amplitude. Here, and contrary to the general belief,...

Modelling the predictors of internet addiction and internet use: a cross-sectional study among undergraduate university students in Ghana

Despite the high prevalence of Internet addiction in previous studies, there is an existential dearth of epidemiological data among Ghanaian tertiary students on the associated factors. We sought to model the factors associated with internet addiction and use among university stu...

Mandated to Change, Pressured to Survive: How Newly Appointed CEOs Use Resonance to Manage Strategic Change–Early Survival Dilemma

Abstract Newly appointed CEOs often enter office with a mandate to initiate strategic change, yet such change disrupts established routines and interests, frequently provoking resistance from organizational stakeholders. This creates a fundamental leadership transition dilemma: t...

Parametric study on drilling induced damage in thick unidirectional carbon-epoxy composite laminates

The growing application of carbon fiber-reinforced polymer (CFRP) composites in aerospace, automotive, marine, and structural engineering demands reliable, damage-controlled machining approaches, particularly for drilling operations critical to assembly and mechanical fastening....

Towards a Theory of Institutionally Embedded Preferences

This paper develops a decision-theoretic formalization of how informal institutions affect economic decision-making. Standard behavioral and institutional models widely recognize that social institutions influence economic choice. However, they frequently represent this influence...

Ethical Standards Compliance and Healthcare Services Delivery in Edo State Public Hospitals

Healthcare service delivery is described as the cornerstone of public trust in government. This study examined the influence of ethical standards compliance on healthcare service delivery in Edo State public hospitals. Specifically, it assessed the current state of ethical compli...

范式延拓与文明补位:生产型政治哲学与新世纪诺贝尔经济学奖的学术对话 ——学术坐标系定位

English Abstract: This appendix aims to establish a clear academic coordinate system for the "Productive Political Philosophy" framework through a systematic dialogue with the core contributions of 21st-century Nobel laureates in economics. It argues that the past two decades of...

E8‑Phi Resonant Acoustic Coding for Adaptive Market Prediction — E8 Intelligence Research

By scaling the 240 E8 root vectors with the golden ratio φ and driving them coherently at the lattice's 132 Hz phonon resonance, a stable quasi‑periodic acoustic potential emerges that maps the lattice's symmetry onto a continuous wave field. This field encodes temporal phase rel...

A Structural Reduction of the Riemann Hypothesis to Critical-Line Completeness

Abstract This preprint develops a structural reduction and falsification framework for the Riemann Hypothesis (RH), without claiming a proof of RH. A nontrivial zero is parametrized as ρ=21+δ+iγ, so that RH requires δ=0 for every nontrivial zero. The manuscript examines and expli...

The Challenges of Providing Technical Evidence in Witchcraft Cases: A Forensic Perspective

Adjudicating witchcraft-related cases presents a formidable challenge due to the difficulty of procuring technical evidence for claims rooted in supernatural beliefs. This study examines these complexities through the lenses of forensic science and Cultural Deviance Theory, using...

Foundation Model Deprecation Economics: The Hidden Cost of Model Version Migrations

Research article: Foundation Model Deprecation Economics: The Hidden Cost of Model Version Migrations

Elevated IL-10 is Linked With the Expansion of T-bethighCD21low B Cells in Patients With Common Variable Immunodeficiency

Abstract Common variable immunodeficiency (CVID) is frequently complicated by autoimmune and inflammatory manifestations associated with profound immune dysregulation (CVIDc), including expansion of T-bet high CD21 low B cells (CD21 low B cells). Elevated serum IL-10 levels have...

Layered Protocol Cosmology after Prototype Reassessment: Core Hypotheses, Minimal Formal Specification, and Research Boundaries / 層状プロトコル宇宙論(LPC)の原型再評価

【English Abstract】 Layered Protocol Cosmology (LPC) has previously been explored through several model-specific and effective constructions, including complex-field, higher-dimensional and open-system candidates, a Brans--Dicke-type effective description with logarithmic inform...

ECKART — a model-agnostic research companion: method note

Manuscripts by this author carry a standing acknowledgment describing how they came about.That acknowledgment refers here for the one thing it cannot carry itself: which tools and models were in use, and when.A published paper freezes. The tooling does not. A model version named...

A CombinedChemical Ionization and Photoelectron IonizationSource for TOFMS: Application to Online Detection of Aldehydes inEnd-Tidal Exhaled Breath

Abstract In conventional exhaled breath analysis, a CO2 sensor is typically deployed separately from a biomarker detection instrument. Herein, we developed an all-in-one ionization source that integrates chemical ionization (CI) and photoelectron ionization (PEI) within a single...