Research works

Pure Geometric First-Principles Derivation of the Fine-Structure Constant alpha^-1 ≈ 137.035999 via 3D Holographic Topology and the 2^-24 Machine Epsilon Theorem

The fine-structure constant (alpha ≈ 1/137.035999) is the dimensionless coupling constant characterizing electromagnetic interaction strength, traditionally regarded as an empirical parameter that cannot be derived from pure mathematical theory. In this paper, based on the three-...

CX3CR1 Modulates Migration of Resident Microglia Towards Cortical Laser‐Induced Lesions

Microglia are innate immune cells of the central nervous system (CNS). They extend their processes and migrate toward injuries in vivo. However, how the fractalkine receptor (CX3CR1) influences microglial migration remains unknown. Label-free proteomic profiling predicted changes...

Companion AI Under the EU AI Act: A Compliance Gap Analysis

Companion AI and other LLM-based relational services are growing at a pace that can't be ignored and the recent regulations are attempting to keep up with the rise in user rates. As some humans are choosing relationships with algorithms rather than choosing a human partner, it's...

Antitubercular evaluation and synthesis of fused pyrano-thiazole-2-one derivatives via green and efficient protocol

Tuberculosis has become one of the leading causes of mortality worldwide. In developing countries, tuberculosis is one of the 10th leading causes of death, highlighting the urgent need for antitubercular drugs. In this study, we synthesized fused pyrano-thiazole-2-one derivatives...

A Heating-AssistedIntegrated Purification-Enrichment-DerivatizationPaper Chip for Rapid MS/MS Quantification of Serum Steroid Hormones

Abstract Rapid and reliable simultaneous quantification of multiple steroid hormones is important for the diagnosis and monitoring of endocrine disorders such as polyendocrine metabolic ovarian syndrome (PMOS), formerly known as polycystic ovary syndrome (PCOS). Existing methods...

Holographic Information Ontological Framework • The Brain — Paper III: Consciousness, the Unconscious, and the Geometry of Psychopathology

Holographic Information Ontological Framework: The Brain (HIOFtB) This is a four-paper series plus a short companion note. It is written for readers in neuroscience, consciousness studies, algebraic topology, and the philosophy of mind -- not as a finished theory, and not only fo...

Geometry vs Binary: Quantum Physics Puzzles — quantum geometry topological error correction AI f — E8 Intelligence Research

## Binary Failure → Geometry Solution **Analysis of Findings:** The search results reveal a critical frontier where conventional AI and binary computation hit a fundamental wall: **topological quantum error correction (QEC)**. Current approaches rely on neural networks or statist...

A Biopsychosocial Model of Athlete Performance: Integrating Psychological Skills, Coaching Competence, Nutritional Readiness and Well-Being Among Nigerian University Athletes

A biopsychosocial approach to athlete performance was adopted by considering the interrelationships and combined predictive power of psychological skills, coaching competence, nutritional readiness, and athlete well-being on athlete performance among Nigerian university athletes....

Comparative Genomic Annotation Gap Analysis: Feed-Efficiency Candidate Genes in Cattle vs. Water Buffalo (Bubalus bubalis)

Genomic selection tools for feed efficiency have been extensively developed and validated in high-input cattle breeds, but it is unclear whether the same candidate genes are equally well characterized in water buffalo (Bubalus bubalis), the dominant dairy species across Pakistani...

Effects of institutional quality and gender imbalance on carbon intensity in China

Climate change and rising carbon dioxide (CO₂) emissions remain central challenges to global sustainable development, particularly in rapidly industrializing economies such as China. This study examines the long-run association between institutional quality, gender imbalance, ren...

Replication material for: Böhmelt, T., Ward, H., & Bernauer, T. (2025). Do welfare states have lower carbon emissions? The importance of state capacity in lower-income countries. Journal of Public Policy, 45(3), 428–448. doi:10.1017/S0143814X25000121

These files contain the replication materials for the paper: Böhmelt, T., Ward, H., & Bernauer, T. (2025). Do welfare states have lower carbon emissions? The importance of state capacity in lower-income countries. Journal of Public Policy, 45(3), 428–448. doi:10.1017/S0143814X250...

AIVI Index: A Public Methodology for Measuring Brand Representation in Generative AI Answers

The AIVI Index measures brand representation in the answers of generative AI systems — presence, visibility, citation, accuracy, and tone — under a fixed, published protocol. This document sets out the public methodology of the index in full: the five-factor construct, the query...

Adaptive Thresholding in AI-CDSS: Dynamic Clinical Decision Boundaries for Evolving Patient Populations — A Narrative Review

Background. Artificial intelligence-based clinical decision support systems (AI-CDSS) typically convert a model's predicted risk into an actionable recommendation by comparing the output against a fixed decision threshold. Such static boundaries implicitly assume a stable patient...

Spatial typology and differentiated conservation pathways of trade-oriented ancient towns along the Beijing–Hangzhou Grand Canal

Abstract This study examines 52 trade-oriented ancient towns along the Beijing–Hangzhou Grand Canal, combining GIS analysis, morphological indicators, and space syntax in a composite model classified via PCA and K-means clustering. Towns cluster significantly along the canal (NNI...

Twin Prime Conjecture Unproven Despite Maynard's Bounded Gaps and Unverified Preprint — E8 Intelligence Research

FINDING: No proof of twin prime conjecture found; recent advances by Maynard show bounded gaps between primes, but infinitude of twin primes remains unproven. One arXiv preprint claims a constructive sieve method but lacks peer-reviewed validation. MATH: Twin prime conjecture: li...

The Joshi ATS Series under the Bridge-Certificate Standard: A Targeted Substance Audit and an All-Place Rigidity Classification of Effective Normalization Weights (DRAFT)

DRAFT / work in progress. This is a versioned working paper of an ongoing research programme; newer versions supersede older ones. No claim about the truth of the abc conjecture, the correctness of IUT, or the correctness of the ATS series is made. This paper reports a targeted s...

Observer Position and Resolution of Topological Degeneracy in UCT v6.1.4 Quasicrystalline Cosmology

Abstract (English) Within the framework of Unified Topological Cosmology (UCT v6.1.4), the macroscopic structure of spacetime is modeled by the Poincaré dodecahedral space $\mathcal{M}_{\text{UCT}} = S^3/I^*$, composed of 120 regular dodecahedral cells. This paper addresses the f...

Current Use, Monitoring and Reversal of Neuromuscular Block in Pediatric Anesthesia and Intensive Care: A Web‐Based Cross‐Sectional ESAIC Survey

BACKGROUND: Neuromuscular blocking agents are recommended by the European Society of Anaesthesiology and Intensive Care (ESAIC) and European Society of Paediatric Anaesthesia (ESPA) for facilitating tracheal intubation in children. Despite these recommendations, real-world data o...

From overweight/obesity to metabolic syndrome: increased postoperative survival risk in gastric cancer

Overweight/obesity and metabolic syndrome (MetS) are recognized as potential risk factors for gastric cancer, but their impacts on postoperative morbidity and overall survival (OS) following radical gastrectomy remain controversial. We hypothesized that overweight/obesity and Met...

Phi-Harmonic Root Encoding of Neural Temporal Binding — E8 Intelligence Research

The 240 root vectors of E8 are mapped to discrete 2-bit phase markers that lock onto the 132 Hz phi‑vortex carrier, establishing deterministic error‑resilient phase windows. Each of the eight root‑vector clusters creates a unique binding window that aligns with synaptic clock bou...