Research works

Power-Saving Center-Failure Counts for the Derivative Laguerre Inequalities of the Riemann Xi Kernel

This preprint studies the asymptotic number of failures of the derivative Laguerre inequalities at the symmetry point of the standard Jacobi-theta kernel associated with the Riemann Xi function. Building on a previous transition analysis, it strengthens the known qualitative coun...

Immunomodulatory metabolites in rheumatic diseases

Low-molecular-weight metabolites are attracting attention as a group of molecules that play important roles in immune cell function. Recent studies have revealed that metabolites actively regulate immune cell differentiation and function rather than simply reflecting metabolic st...

LAB #1053 PROMISING: LEDGER BENCH: Apply filter: Min confirmations >= 6 — improves win rate from 31.6% to 41.2% (+9.6pp, — E8 Intelligence Research

IDEA: Adjustment made to the live model — verify against the backtests: Apply filter: Min confirmations >= 6 — improves win rate from 31.6% to 41.2% (+9.6pp, n=328) SAME-WINDOW EFFECT: Over the current trade window, applying a minimum of 6 confirmations would have rejected the EU...

BASE 44 ORDER: Implement e8_freq_bucket column, index, agent filter, pinned workers, pre-warm query — E8 Intelligence Research

Andrew's order (Base 44 console): [SELF-BUILD from enhancement #1128] Add e8_freq_bucket smallint column to breakthroughs table. Populate with hash(breakthrough_id)%240. Create partial index on (e8_freq_bucket, breakthrough_id). Modify Python agent queries to filter by bucket. Pi...

Freedom Without Blueprints: The Intrinsic Limitation of Social Schemes in Lao-Zhuang Philosophy and the Austrian School

Most comparative studies between Daoist thought and the Austrian School remain superficial, confined to listing vague similarities of "anti‑intervention" and "advocating freedom". Existing scholarship has consistently missed the most essential, paradigm‑defining consensus shared...

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

ABSTRACT Thymic epithelial tumors (TETs) are rare and heterogeneous malignancies whose aggressive epithelial states and microenvironmental organization remain poorly defined. Here, we integrated single‐cell RNA sequencing, spatial transcriptomics, multiplex immunofluorescence, bu...

Resolving JWST High-Redshift Anomalies with the UAT/UCP Framework: Causal Redshift Correction and the Restoration of Cosmic Chronology

This Zenodo repository contains the corrected and updated manuscript, Python code, and supplementary material for the study "Resolving JWST High-Redshift Anomalies with the UAT/UCP Framework: Causal Redshift Correction and the Restoration of Cosmic Chronology" by Miguel Angel Per...

Lung Cancer: From Pathogenesis to Patient Care

Lung cancer remains the leading cause of cancer-related mortality worldwide, accounting for millions of new cases and deaths each year despite substantial advances in prevention, diagnosis, and treatment. A major challenge is that many patients are diagnosed at an advanced stage,...

Symmetric Pairs on Primorial Wheels

Placing a mirror at the center of a sieve reveals more structure than the usual picture of crossed-out multiples. At a center built from a primorial, the first sieve stages leave an exactly countable wheel of symmetric pairs. Every later prime meets that wheel along a small famil...

Annual-resolution evidence for aridity spikes at the onset of the Last Glacial Inception in an Eifel maar lake sediment

Abstract This study presents an annually laminated sediment record from the infilled maar lake at Hoher List in the Eifel volcanic field (Germany), documenting the “Last Glacial Inception” (LGI) at the end of the Eemian interglacial. The landscape of the late Eemian was dominated...

HAQOOQ | حقوق الله وحقوق العباد — What You Owe Allah and What You Owe Humanity — Institutional Research & Book Framework Edition

HAQOOQ | حُقُوق الله وحُقُوق العِباد By Syed Raheel Shahzad is Stage 7 of The Source of Truth System™ and a structured inquiry into rights, duties, justice and answerability. It examines what is owed to Allah, to the self, to parents, spouses, children, neighbours, communities an...

Coarse-Graining as Ontology: The Physical Foundations of Emergent Reality in the CSF-CMT Framework

For more than a century, the relationship between microscopic fundamentality and macroscopic reality has been framed as an epistemological problem: coarse-graining is merely an approximation scheme that loses information. This paper argues, conversely, that coarse-graining is an...

Seismic Stability Analysis of Vertically Expanded Landfills under Different Leachate Buildup Conditions

Abstract Expanding existing landfills offers a more economical and practical solution than constructing new disposal sites, especially in urban regions where land availability is limited. This study investigates the seismic stability of vertically expanded side-hill-type waste la...

Achyranthes bidentata polysaccharides alleviate severe traumatic brain injury by suppressing the TLR4/MyD88/NF-κB pathway and inhibiting neutrophil extracellular trap formation

Objective This study aims to investigate the potential protective effects of Achyranthes bidentata polysaccharides (ABPS) against severe traumatic brain injury (sTBI) and to elucidate the underlying mechanisms. Methods A sTBI model was established using a modified free-fall impac...

Quadratic Completion of Admissible Spectral Pairs via Binary-Icosahedral Representation

We investigate the structural nature of the pair observable $\sigma_{\mathrm{pair}}(n) = \sigma_c(n)\,\sigma_{q-c}(n)$ arising in the Weil-block analysis of the Heisenberg Cayley graphs $\mathrm{Heis}_3(\mathbb{Z}/q\mathbb{Z})$. Building on the canonical construction of conjugate...

The Mathematics of Factors: Risk, Alpha, Detection, and Capacity

Quantitative finance uses "factor" for two distinct objects: a risk direction along which returns covary and an alpha direction along which returns are predictable. We assign each direction gauge-invariant common-covariance strength and predictive content, separating covariance r...

A uniform sub-three-fifths bound for exceptional abc triples

GPT 5.6 Sol discovered the result and proof presented in this paper. We establish a new uniform upper bound for the number of exceptional abc triples throughout the full subcritical range. The proof combines an anatomic decomposition with Fourier analysis, geometry-of-numbers est...

Fetal Alcohol Spectrum Disorder (FASD) and Harmful Sexual Behaviours or Sexual Offending: A Systematic Scoping Review

Abstract Previous research has shown that individuals with Fetal Alcohol Spectrum Disorder (FASD) are more likely to be overrepresented in the criminal justice system (CJS) compared to those without FASD. Criminal justice encounters can involve a range of harmful sexual behaviour...

On the Structural Uniqueness of Quantum Gravity: Gauge-Holographic Reduction of Ambiguity in the BV Formalism

We formalize the heuristic systemic principle defining physical determinism as the ratio of redundancy to organizing constraints into a rigorous framework of quantum gauge theories. Within the Batalin-Vilkovisky (BV) formalism, we investigate a comprehensive effective action of q...

Synthesis of polyhydroquinoline derivatives as potent antidiabetic and antioxidant agents: in vitro biological activities and computational studies

Aims Diabetes mellitus (DM) is a severe metabolic disease characterized by increased blood glucose levels due to reduced insulin action or secretion. This study aimed to synthesize new polyhydroquinoline (PHQ)-based acyl hydrazide derivatives and assess their potential as dual in...