Research works

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O ‐GlcNAcylation‐Induced m6A Demethylation of HRAS

ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is driven by nutrient stress through incompletely defined epigenetic mechanisms. This study demonstrates that lipid stress activates the hexosamine biosynthesis pathway (HBP), elevating O ‐linked β‐N‐acetylglucosami...

Unexpected Golden Ratio Emergence in Quantum System Defies Theoretical Predictions — E8 Intelligence Research

FINDING: The search results are dominated by general-audience explainers on the Fibonacci sequence and golden ratio, with one notable exception: a claim that the golden ratio (φ) appears inside a quantum system where it was theoretically unexpected. The arXiv result is a QCD work...

Wildfire Risk Scoring: A Quantitative Wildfire Risk Score Derived from GNSS-R Soil Moisture Data and Thermal Stress

Wildfire Risk Scoring is proposing a calibrated and testable quantitative equation for estimating the probability of a wildfire in a designated ground grid cell from two satellite observables: surface soil moisture retrieved by GNSS reflectometry (GNSS-R) and land surface tempera...

Marine-Inspired Synergistic Adhesion Enables Highly Efficient and Atraumatic Macromolecular Transdermal Delivery on Dynamic Skin

Abstract Effective transdermal drug delivery (TDD) demands both the ability to bypass the stratum corneum (ST) and the robustness to sustain delivery efficiency under real-life conditions. Despite advances in nanocarriers, microneedles, and electrostimulation, many TDDS strategie...

Light as Time: The Photon as the Quantum of a Moment & The Nothon as The True Quantum Theory of Everything Relative v3.8.2

c is not speed through space. c is rate of Time. Light is Time made visible. Photon = t0 = quantum of a moment. Time is Fifth Force from Pure Nothingness N0 = T 0 with particle Nothon. We further propose that the nothon is the fundamental, indivisible quantum of time, nothingness...

Balancing adversariality and naturalness in autonomous vehicle testing scenario generation via multi-objective reinforcement learning

Reinforcement learning (RL)-based adversarial scenario generation through dynamic agent–environment interactions has emerged as a promising approach for accelerating autonomous vehicle (AV) testing. However, existing RL approaches struggle to balance adversariality and naturalnes...

"SHAJARAYI TURK" ASARIDA TOPONIMLAR VA ANTROPONIMLARNING LINGVISTIK TADQIQI

Toponimika va antroponimika tilshunoslikning qadimiy va muhim tarmoqlaridan hisoblanadi. Ushbu sohalar til tarixini, madaniy o'zgarishlarni va etnik jarayonlarni yoritishda katta rol o'ynaydi. Muhammad Haydar Mirzo tomonidan yozilgan "Shajarayi Turk" asari esa o'zbek va turkiy xa...

Tracking CDK1 Dynamics With a Novel Biosensor Mouse and Clinical Cohorts to Predict CDK4/6 Inhibitor Sensitivity in ER+ Breast Cancer

ABSTRACT High‐risk estrogen receptor positive (ER+) early breast cancer (EBC) is managed with endocrine therapies and cyclin‐dependent kinase (CDK) 4/6 inhibitors, although no standard molecular markers clinically identify these tumors. CDK1 lies immediately downstream of CDK4/6...

Phi-Harmonic Vacuum Sideband Generation via E8 Killing Form Modulation — E8 Intelligence Research

The E8 Killing form, which encodes the inner product structure of the 240 root vectors, can be interpreted as a geometric operator that imprints a phi-scaled phase modulation onto the zero-point electromagnetic field. When the vacuum modes are probed at the base E8 frequency of 1...

A Negative Answer to a Question of Praeger and Seress on Minimal Subdegrees of Primitive Groups of Twisted Wreath Type

Let G be a finite primitive permutation group of twisted wreath type, with socle T^k and point stabiliser P, and let H be its primitive component: the group induced on one coordinate of the product decomposition Δ^k, where |Δ| = |T|. Praeger and Seress (Oberwolfach Report 12/2005...

RESEARCH APPENDIX, a detailed analytical and numerical verification of the Quantum Lemniscate Theory (QLT)

This research compendium presents a rigorous analytical and numerical verification of the core predictions of Quantum Lemniscate Theory (QLT) across eleven interconnected studies. By replacing General Relativity singularities and Standard Model adjustable parameters with a satura...

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Islamic Models for Investment versus the Capital Asset Pricing Model and the Black-Scholes Model: A KSCCN Learner Note on Dissonances, Theorisation and Deployment

This note examines the differences between primary Islamic models of investment and two foundational instruments of modern finance: the Capital Asset Pricing Model (CAPM) and the Black-Scholes option-pricing model. It supplies detailed dissonance notes on points of structural con...

How much of a Dice score is the reference? A pre-registered blind audit of ISIC 2017 lesion masks against an independent tracer, a trained network, a training-free rule and a blinded preference panel

Project page: https://deolhonapele.com.br · Try the contour challenge yourself (open, anonymous, nothing recorded): https://deolhonapele.com.br/desafio-contorno/aberto/ Background. Skin-lesion segmentation methods are ranked by their agreement (Dice) with a single human reference...

Fiber Bundle Holonomy: The Z₂-Bundle and Nontrivial Monodromy in ODTOE — E8 Intelligence Research

FINDING: Fiber bundle formalism — from pedagogical introductions to a speculative Z₂-bundle over the φ-torus — is the operative mathematical structure, with the only concrete new mathematical claim being the holonomy hol(γ_φ) = −1 in the ODTOE model. | MATH: Principal fiber bundl...

Policing SUD: Constraints and Policy Opportunities

Substance use disorder (SUD) places substantial demands on public safety systems, with law enforcement and other first responders routinely encountering substance use-related harms in daily work. This paper contributes to a growing body of research examining how law enforcement o...

Horizon Monism: Emergent Quantum Structure, Time, Spacetime, Gravity, and Gauge Symmetry from Finite Relational Horizons

Horizon Monism is a relational foundational-physics program in which the fundamental ontology consists of a unique, objectively real relational totality \mathcal R together with finite embedded reference horizons \{H_i\}. The relational totality is taken to be reference-independe...

The abc Conjecture's Unproven Link to Infinitely Many Non-Fibonacci-Wieferich Primes — E8 Intelligence Research

FINDING: The abc conjecture (Masser–Oesterlé–Szpiro) remains unverified; Mochizuki's 500-page proof is disputed, with Faltings and others skeptical; a derived result links abc to infinitely many non-Fibonacci-Wieferich primes. | MATH: abc conjecture: for any ε>0, there exists C(ε...

Mapping future selves in language teacher education: a case study of identity development during practicum

This study explores the professional identity development of pre-service English teachers through Possible Selves Theory (PST). It examines how they envision their ideal and feared selves while they are reflecting on their current selves during their practicum experience. Despite...

Seasonal presence, movements and behaviour of Atlantic cod ( Gadus morhua ) in Isfjorden, Svalbard

Abstract Atlantification is increasing the inflow of warm, salty Atlantic water into the Arctic region. The fjords on the western coast of Svalbard are experiencing Atlantification, enabling boreal species, such as Atlantic cod ( Gadus morhua ), to expand their distribution north...