Research works

Orally available Colivin traps TRPV3 in an inactive state and suppresses intestinal inflammation

Abstract Transient receptor potential vanilloid 3 (TRPV3) is a non-selective cation channel highly expressed in the skin and intestine. While its roles in itch and skin inflammation are established, the physiological role of TRPV3 in the intestine remains relatively poorly unders...

Psychoactive Medication Prescribing After Critical Illness in American Adults Not Justified by a Documented Supporting Diagnosis

Objectives: To describe psychoactive medication (PM) prescribing in the 30 days after an ICU admission requiring mechanical ventilation not supported by a documented diagnosis in American adults not prescribed a PM before ICU admission. This nondiagnostically supported PM prescri...

Lights, camera, coopetition: film and television production in a peripheral region

While ‘coopetition’ – the simultaneous competition and cooperation of firms in regional clusters – supports regional value creation, its dynamics in peripheral regions remain underexplored. This research addresses this gap by examining the antecedents of coopetition in the film a...

Development ofa Shapley Additive Explanations (SHAP)-InterpretableModel for Cardiovascular Risk Stratification in Type 2 Diabetes Mellitus:Implications of MDA-Modified Protein Adducts and Autoantibodies

Abstract Coronary artery disease (CAD) is the leading cause of mortality in type 2 diabetes mellitus (T2DM). This study explores the two-hit oxidative–immune hypothesis by evaluating malondialdehyde (MDA)-modified protein (MDA-protein) adducts and their corresponding autoantibodi...

Sociolinguistic scales and the texturing of three staircases: Bodies, memories and affect

This article explores staircases as multimodal sites for semiotic and epistemic reflection on meaning-making. Building on the shared etymology of staircase and scale , and drawing on a scalar understanding of semiosis, I analyse three installations— A Stumbling Staircase , A Stai...

A Multi-View Attention–Similarity Decision-Support Framework for Core Feature Recognition in Design Patent Infringement Assessment

Identifying core features is a crucial step in design patent infringement assessments (DPIAs), as the identification results serve as a vital basis for subsequent qualitative and quantitative assessments. Traditional DPIAs typically rely on the experience and knowledge of experts...

Measurement data quality in room acoustics: A systematic audit framework for field campaign errors and their quantified impact on machine learning prediction performance

Acoustic impulse response measurement campaigns conducted in performance venues under ISO 3382-1 are susceptible to a class of systematic field errors, including receiver position labelling swaps, spatial co-ordinate entry mistakes, signal-to-noise ratio failures at low frequenci...

Non-solvating additives regulate zinc deposition through anion-gated Stern-layer competition

Abstract While additive-induced modulation of solvation structure has emerged as an effective strategy to enhance the performance of aqueous zinc-ion batteries, the electrochemical mechanisms by which non-solvation additives interact with ion species within the electric double la...

AQbD Driven RP-HPLC method for estimating rizatriptan benzoate and meloxicam: integrating green and blue analytical approaches

The present study aimed to develop and validate a robust, stability-indicating RP-HPLC method for the simultaneous determination of Rizatriptan Benzoate and Meloxicam using an Analytical Quality by Design approach integrated with green analytical principles. A central composite d...

Osteoporosis treatment with biosimilars in Malaysia and Thailand: a budget impact analysis

Abstract Introduction Biologic treatments demonstrate long-term clinical benefits for patients with osteoporosis, but their cost is prohibitive, and access can be limited, particularly in low-income countries. This analysis determined the cost impact of introducing biosimilar den...

Thermodynamic characterization of Lewis acid–base interactions on carbon nanomaterials: Validation and Universality of the Hamieh five-parameter model

Understanding the Lewis acid–base properties of carbon materials is essential for predicting adsorption behavior, catalytic performance, and interfacial interactions. In this work, eight carbon materials—graphene, graphene oxide, reduced graphene oxide, untreated carbon fiber, ox...

Geosynthetic Applications and Design Methods for Paved and Unpaved Road Systems in Minnesota: Review of Current Practice

Geosynthetics are widely used in pavement systems in multiple applications, including base and subgrade stabilization, reduction of layer intermixing and moisture, and mitigation of shrink/swell-related distresses. However, the current geosynthetic classification system and guide...

A Performance-based Eco-efficiency Framework for Green Concrete Incorporating Silica Fume and Recycled Aggregates

Introduction This study evaluates the combined use of silica fume (SF) and recycled coarse aggregates (RCA) in green concrete and proposes a CO 2 -efficiency-based index to compare mixtures that considers both environmental impact and engineering performance. Methods Concrete mix...

Kinetically ProgrammedThermoresponsive PolyethyleneGlycol Shedding from Lipid Nanoparticles Improves mRNA Delivery

Abstract Polyethylene glycol (PEG) can stabilize nanoparticles and facilitate transport across biological barriers, yet the same PEG layer suppresses cellular uptake─a trade-off known as the PEG dilemma. Current strategies seek to overcome this limitation by enabling PEG shedding...

BKT–37Y07 Operator Identifiability, Renormalized Wilson Junctions, and Hierarchical Closure of the Proton

Operator Identifiability, Renormalized Wilson Junctions, and Hierarchical Closure of the Proton The BKT–37Y07 publication constitutes the next stage of the multipart proton research programme developed from the principal BKT–37 article within the PJM–GTWSSF–USC–GTCW framework. Th...

PHILIA OS Phase 2 · 109th DOI Results Report: TextAnalyzer CH7-v20 — SVO Claim-Slot Zeroing for Intra-Document Factual Locus Selection (Exploratory Study)

This record contains the 109th DOI Results Report of the PHILIA OS research series (Trinity AI Research Team, Konyang University), reporting the exploratory study results of PHILIA TextAnalyzer CH7-v20. CH7 is an evidence retrieval pipeline that fetches factual information from W...

Second-generation bioethanol from lignocellulosic biomass: An integration-oriented review of pretreatment, bioconversion, techno-economic assessment, and industrial perspectives

The growing demand for sustainable energy and the environmental impacts of fossil fuel use have accelerated the development of renewable alternatives, particularly biofuels. Among them, second-generation (2G) ethanol produced from lignocellulosic biomass has emerged as a promisin...

Customer Trustworthiness and Procedural Fairness on Relationship Marketing Performance of Food Suppliers in Multi-Customer Relationships

This study examines how a food supplier’s perceptions of customer trustworthiness relate to its customer concentration, the extent to which a supplier’s sales are unevenly distributed across its major customers, and how customer concentration is associated with procedural fairnes...

Mechanism Study on Deep Removal of Lattice Impurities from High-Purity Quartz by Chlorination Roasting

High-temperature chlorination roasting is a critical technique for achieving ultra-high-purity quartz required in semiconductor, photovoltaic, and fiber-optic applications. However, the removal mechanisms of lattice-bound impurities remain poorly understood due to a lack of integ...

How Natural Origin Achieves the Algebraization of Special and General Relativity

This paper develops the algebraization of relativity by reconstructing the foundational expressions of both special relativity and general relativity. For special relativity, the paper does not begin with coordinate transformations. Instead, it begins with right handed light spee...