Research works

Séminaires de Géométrie Algébrique (SGA) — French/English Canon and Current Readers

French/English Canon hub for SGA 1 through SGA 7 II. Start with the 4,204-page cumulative English reader; standalone readers are direct files. The deterministic French archive contains corrected/current and preserved original/diplomatic layers. A separate provenance ZIP records a...

Transposon end recognition and excision mechanisms of type I-F CRISPR-associated transposases

Abstract CRISPR-associated transposons (CASTs) are Tn7-like elements that have co-opted RNA-guided CRISPR effectors for targeted DNA insertion. CASTs have been adapted as genome editing tools for programmable, site-specific integration. Among them, the type I-F system from Ps e u...

Presymptomatic plasma biomarkers in autosomal dominant Alzheimer’s disease: sequence and timing

Abstract Background Autosomal dominant Alzheimer’s disease (ADAD) serves as a model for presymptomatic biomarker discovery. Characterising the temporal profile of plasma biomarker levels in presymptomatic individuals may enhance understanding of disease pathogenesis, inform futur...

Understanding the Evolution and Clade Diversity of Mayorella (Amoebozoa): Description of a Novel Species From Freshwater Near Cape Coast, Ghana

Mayorella species are globally distributed amoeboid protists, yet their diversity remains poorly resolved because of pronounced morphological plasticity and limited molecular data. Freshwater ecosystems of West Africa remain particularly underexplored, with virtually no integrati...

Machine Learning of Temperature‐Dependent Chemical Kinetics Using Parallel Droplet Microreactors

Temperature is a fundamental regulator of chemical and biochemical kinetics, yet capturing nonlinear thermal effects directly from experimental data remains a major challenge due to limited throughput and model flexibility. Recent advances in machine learning have enabled flexibl...

Form and function of actin impacts actin health and aging

Abstract The actin cytoskeleton is a fundamental and highly conserved structure that functions in diverse cellular processes, yet its direct contribution to organismal aging remains unclear. Here, we systematically interrogated how genetic and pharmacologic perturbations of actin...

Stable tendencies in spontaneous working memory usage during flexible behaviour

Abstract Unlike standard working memory (WM) tasks, real-world settings allow individuals to spontaneously adapt how much information to use from WM before resampling the environment. Here, we considered whether individuals exhibit distinct, trait-like tendencies in their spontan...

Are individual differences in “unconstrained thought” meaningfully distinct from spontaneous and deliberate mind wandering?

Here, we developed the Unconstrained Thought Questionnaire (UTQ) to assess the dynamics of unconstrained thought (or ‘mind wandering’), as described by the Dynamic Framework. We aimed to determine whether the UTQ’s measure of unconstrained thought provides unique explanatory powe...

A simple characterization of Quillen adjunctions

Abstract We observe that an enriched right adjoint functor between enriched model categories which preserves acyclic fibrations and fibrant objects is quite generically a right Quillen functor.

Double robust, flexible adjustment methods for causal inference: An overview and an evaluation

Double robust methods for flexible covariate adjustment in causal inference have proliferated in recent years. Despite their apparent advantages, these methods are rarely used by social scientists. It is also unclear whether these methods actually outperform more traditional meth...

Does Digitalization Widen Labor Income Inequality?

ABSTRACT We develop a growth model that endogenizes the occupational choice of workers with different ability levels to study how digitalization affects labor income inequality. The framework incorporates digitalization's multifaceted effects on the economy: (i) it influences eco...

Collaborative Inference and Learning between Edge SLMs and Cloud LLMs: A Survey of Algorithms, Execution, and Open Challenges

As large language models (LLMs) evolve, deploying them solely in the cloud or compressing them for edge devices is increasingly inadequate due to latency, privacy, cost, and personalization concerns. This survey examines a collaborative paradigm in which cloud-based LLMs and edge...

Multi-resolution enhancement for full-spectrum neural representations

Scientific data acquisition continues to outpace storage and analysis capabilities, making voxel-based representations increasingly intractable. Implicit neural representations (INRs) offer a promising solution by encoding signals through coordinate-based neural networks, serving...

Beyond benchmarking: an expert-guided consensus approach to spatially aware clustering

Spatial omics technologies have revolutionized the study of tissue architecture and cellular heterogeneity by integrating molecular profiles with spatial localization. In spatially resolved transcriptomics, delineating higher-order anatomical structures is critical for understand...

Local Shocks and Regional Dynamics in an Aging Economy

ABSTRACT This paper studies how population aging shapes regional adjustment to local shocks. I develop a dynamic spatial general equilibrium model that incorporates aggregate demographic change, life‐cycle variation in migration and employment choices, and forward‐looking investm...

Modulation of the cytoskeleton for cancer therapy

Introduction All degenerative diseases are associated with impairment in intracellular trafficking. The highly dynamic organization and remodeling of the cellular cytoskeleton are dysfunctional in pathology and often lead to drug resistance. Successful analyses of the mechanisms...

The five logics of the humanitarian migrant services industry

Humanitarian migration services can institute forms of governance that commodify clients and extract values from the labor power of low-wage non-migrant and migrant workers and volunteers. These processes were identified through an ethnography of migrant service provision in a di...

Cohesin acts as a transcriptional gatekeeper by restraining pause–release to promote processive elongation

Abstract Cohesin organizes 3D chromatin architecture, including promoter–enhancer loops, yet its loss has surprisingly modest effects on steady-state gene expression. We address this paradox by demonstrating that cohesin acts at different stages of transcription. First, it promot...

The Impact of Generative AI on Collaborative Open-Source Software Development: Evidence from GitHub Copilot

Generative artificial intelligence (AI) facilitates content production and enhances ideation, with potentially important implications for developer productivity and participation in software development. To explore its impact on collaborative open-source software (OSS) developmen...

Filtering and Generating: Two Roles for Method-Specification in Epistemic-Possibility Anti-Luck Conditions

Method-relative modal conditions on knowledge are standardly assessed against a similarity ordering over possible worlds fixed independently of the method: the specification restricts which worlds are quantified over, while the metric is given by the world-space. I distinguish th...