Research works

Drosophila melanogaster Models for Natural Product Discovery: Cross-Disease Conserved Signaling Networks and a Generalizable Translational Pipeline

Drosophila melanogaster shares approximately 75% of human disease-related genes and possesses sophisticated genetic toolkits, including GAL4/UAS, CRISPR-Cas9, and RNA interference (RNAi), making it a rapid, cost-effective, and genetically tractable in vivo platform for natural pr...

Chronic Toxoplasma gondii infection and its influence on semen analysis in rats: controlled experimental animal study

Abstract Infertility is a significant global health concern that has been related to various infectious agents. While Toxoplasma gondii ( T. gondii ) is a ubiquitous protozoan parasite that affects various body organs, little is known concerning how it may affect the male reprodu...

Deep learning models for reliable weather forecasting in crowded regions performing traditional or religious activities

Forecasting weather during large-scale traditional or religious events in densely populated regions is particularly challenging because of the ever-evolving microclimatic changes caused by human activities. This study designed and tested two new deep learning-based approaches for...

Spinal Cord Diffuse Midline Glioma: A Lethal Masquerade

Spinal cord diffuse midline gliomas (DMGs) are rare World Health Organization (WHO) grade IV neoplasms with a poor prognosis. Due to the limited number of reported cases and the absence of standardized treatment protocols, most patients undergo biopsy or subtotal resection follow...

Unraveling the protective effect of weekend catch-up sleep on overactive bladder risk

BACKGROUND: Weekend catch-up sleep (WCS) has emerged as a new research focus in the field of sleep. Earlier research has shown that sleep and overactive bladder (OAB) are closely related; however, the connection between WCS and OAB has yet to be reported. METHODS: Data from the 2...

Longitudinal Analysis of Urine Metabolomics in Preterm Infants Based on UHPLC-MS/MS Technique

Background: The metabolic characteristics of preterm infants in the early postnatal period are closely linked to their growth and development. Investigating the corresponding metabolic changes that occur during the early postnatal maturation process of preterm infants may help im...

Relationship Between Psychological Adjustment to Artificial Intelligence and Career Self-efficacy Among Pre-service Teachers in Tertiary Institutions

The rapid integration of Artificial Intelligence (AI) into education and the workplace has created significant psychological and career-related challenges for pre-service teachers. This study examined the relationship between psychological adjustment to Ar tificial Intelligence a...

On Generalized Hermite–Hadamard-Type Inequalities for Convexity with Computational Analysis and Their Applications

This paper establishes a new general integral identity for differentiable functions involving weighted fractional integral operators. By applying this identity together with s-convexity and s-uniform convexity with modulo Φ, we derive several refined Hermite–Hadamard inequalities...

Interpreting Biomarker Discordance in Inflammatory Bowel Disease: Beyond Fecal Calprotectin and C-Reactive Protein

Treat-to-target management in inflammatory bowel disease (IBD) combines symptoms, fecal and serum biomarkers, endoscopy, histology, and cross-sectional imaging, but these measures frequently diverge. Discordance may reflect analytical variation, timing, disease location, phenotyp...

From Cognition to Consciousness

Do we really run into a hard problem once we know what consciousness is? In this essay we approach that question from the bottom up. We begin with the evolutionary history of cognition, from basic reflexes through learning and generalisation. Then we isolate consciousness from th...

Transferrin Promotes Oligodendroglial Differentiation Independently of Iron Binding and Release

. A long-standing question, however, has been whether these effects depend on iron delivery or instead reflect an intrinsic trophic property of the protein. To directly address this point, we used the oligodendroglial precursor cell line Oli-Neu and two previously characterized n...

Estimates for Linear Wave Equation with Scale-Invariant Damping

This study is devoted to deriving precise pointwise estimates for the linear Cauchy problem of the wave equation with scale-invariant damping. The proof relies on representing the solution via Fourier integral operators and employing techniques from microlocal analysis. As an app...

The Visibility Paradox: A Socio-Technical Systems Perspective on the Empowering and Surveillance Effects of Production Data Transparency in Smart Manufacturing

Production data transparency in smart manufacturing simultaneously enhances and impairs employee performance across organizational contexts. Existing research has not resolved this theoretical contradiction. Drawing on socio-technical systems theory, cognitive appraisal theory, a...

The ATC score: a novel efficacy scoring model for risk stratification and personalized management of unresectable HCC patients receiving TACE-lenvatinib-PD-1 inhibitor therapy

Unresectable Hepatocellular Carcinoma (uHCC) has limited therapeutic options. The combination therapy of Transarterial chemoembolization (TACE), lenvatinib, and PD-1 inhibitors (T-L-P) shows promising efficacy, but a tool to predict individual treatment responses is lacking. To d...

Cyclic di-GMP directly reprograms the multidrug resistance machinery via UspG-mediated sequestration of RamR in Klebsiella

The integration of environmental cues to counter selective pressures is crucial for the epidemiological success of major human pathogens. Klebsiella pneumoniae poses an increasing critical public health threat due to its high biofilm forming capacity and adaptive antimicrobial re...

Multi-body dynamics and Gyro-MPC-DOB based trajectory tracking control of live-line working robot

When the Live-line working robot carries out high-altitude operations, uncertainty factors such as external wind disturbance, end-load variations, and body vibration affect the control performance of the robotic arm, resulting in poor trajectory tracking accuracy of the robotic a...

Bronze Age Navigation Math: A Search Result Analysis — E8 Intelligence Research

FINDING: The search results are a mix of popular-media titles and one substantive academic paper; no cuneiform-specific mathematical data is present. The only concrete mathematical content is the arxiv paper on Bronze Age Mediterranean navigation. | MATH: No equations, constants,...

Carbapenem resistance and susceptibility to Ceftazidima/avibactam and Ceftolozane/tazobactam in Pseudomonas aeruginosa and Enterobacterales in a reference laboratory in Lima, Peru: A cross-sectional study

Carbapenem resistance in Pseudomonas aeruginosa and Enterobacterales is a growing threat, with intrinsic and acquired resistance mechanisms resulting in the need for new therapeutic options. In Peru, data on resistance patterns and the effectiveness of new antibiotic combinations...

MSDR-Mamba: A Multi-Scale Branch-Decoupled Routing State-Space Detector for Temporal Action Localization

Temporal action localization (TAL) requires a detector to recognize action categories and estimate temporal boundaries in untrimmed videos. Mamba supports linear-complexity long-sequence modeling, yet a uniform allocation of state-space operators does not explicitly differentiate...

Home Economics and Family Survival: Evaluating Strategies Amid Environmental Challenges in Lagos

This study examined Home Economics and family survival by evaluating strategies adopted amid environmental challenges in selected Local Government Areas of Lagos State, Nigeria. Specifically, the study identified Home Economics strategies adopted by families, examined the environ...