Research works

Nigral DJ-1 gene knockout in tree shrews can induce phosphorylated α-synuclein aggregation and all key phenotypes of Parkinson’s disease

Abstract DJ-1 is a genetic factor associated with Parkinson’s disease (PD), and altered DJ-1 function has been implicated in PD pathogenesis. However, DJ-1 knockout mice fail to reproduce robust PD-like phenotypes or neuropathology, leaving the contribution of DJ-1 deficiency to...

General Theory of Hierarchical Generation

This paper introduces a minimal axiomatic framework for hierarchical generation. Each hierarchical layer is defined by its natural scale, which measures the magnitude of its internal rate of change. Differentiation with respect to this natural scale produces a nested generative s...

Hydrodynamic optimization of a heaving buoy for enhanced wave energy absorption

This study presents a hydrodynamic analysis of an optimised heaving buoy for a single-body point absorber wave energy converter (WEC). A conventional deep-draft cylindrical buoy is modified into a composite single-body configuration consisting of three rigidly coupled sections to...

Evaluating Rate and Time Effects on Cyclically Loaded Offshore Foundations via a Bounding-Surface Viscoplastic Model

Abstract Offshore foundations are subjected to cyclic loading from waves, winds, and operations, and their response is inherently time-dependent and strongly influenced by loading rates due to the viscosity of clays. This study develops a simple yet theoretically robust framework...

A Complete and Rigorous Proof of the Jacobian Conjecture with Lean4 Formal Verification

This paper presents a rigorous mathematical proof of the complex-field Jacobianconjecture. The conjecture states that if �:ℂ� → ℂ� is a polynomial mapping whoseJacobian determinant is a non-zero constant over the entire domain, then � must bea polynomial automorphism of ℂ�. The p...

Fluid–body interactions on a flexible three-dimensional composite hydrofoil

Abstract This study presents an experimental investigation of the flow around a three-dimensional flexible hydrofoil at Reynolds numbers between $${3.6}\times {10}^{5}$$ 3.6 × 10 5 and $${7.2}\times {10}^{5}$$ 7.2 × 10 5 and angles of attack from $${-8}^{\circ }$$ - 8 ∘ to $${8}^...

Geometric Constraints Determine Chemical Bond Parameters: A Unified Scaling Theory of Bond Length, Bond Energy, and Isotope Effects

Chemical bond parameters—bond length, bond energy, and isotope effects—are traditionally treated as element-specific empirical quantities requiring quantum chemical computation. Here we show that these parameters across the entire periodic table are governed by a single geometric...

Dynamic mechanical behaviour of PVA micro-fibre rubber concrete under multi-factor effects

The dynamic mechanical properties of rubber concrete reinforced with polyvinyl alcohol (PVA) micro-fibres under the combined effects of high temperature, corrosive solutions and impact loading were investigated using split Hopkinson pressure bar tests and scanning electron micros...

Association of the Chinese visceral adiposity index with incident cardiovascular disease in cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study

Abstract Background Cardiovascular-kidney-metabolic (CKM) syndrome integrates metabolic abnormalities, chronic kidney disease, and cardiovascular disease (CVD), with stages 0–3 representing a critical window for primary prevention. Whether the Chinese visceral adiposity index (CV...

Green synthesis of CQDs/Ag/talc ternary composite from waste oil tea

This study presents a green and facile strategy for synthesizing a novel carbon quantum dots (CQDs)/silver (Ag)/talc ternary composite through the valorization of waste oil tea (WOT) and natural talc. The synthesis involves a three-step process: first, WOT is hydrothermally conve...

When Does a Quantum Transition Become a Record? Instruments, export, and cadence in finite quantum dynamics

A finite transition grammar does not by itself determine a measurement record. This report separates six layers: transition support, effects, instruments, environmental export, invocation cadence, and autonomous dissipative dynamics. Exact finite witnesses show which implications...

ThermaFlow™ v1.0: Interface-Level Thermal Boundary-Layer Disruption, Controlled Instability, and Spatially Distributed Heat-Transfer Regulation

ThermaFlow™ v1.0 presents a scientific and engineering framework for interface-level control of heat transfer through active manipulation of thermal boundary-layer formation, persistence, residence, instability, shear, and spatial distribution. The work consolidates a family of s...

Programmed Death-Ligand 1 (PD-L1) expression and clinical outcomes in oral squamous cell carcinoma: evidence from a large clinical cohort

BACKGROUND: Despite the recognized biological relevance of the PD-1/PD-L1 axis in immune evasion, the prognostic significance of PD-L1 expression in surgically treated oral squamous cell cancer (OSCC) patients remains largely unclear. OBJECTIVE: To investigate the prognostic sign...

Yang–Mills Dynamics from Projective Spectral Entropy: Vertical Heat-Kernel Variation on the Admissible Fibre

The companion Gravity paper showed that the horizontal variation of the projective spectral entropy functional $S_\Pi[g] = \tfrac{1}{2}\log\det' A_g$ with respect to the base metric produces the Einstein tensor as the infrared-dominant response, through the Seeley–DeWitt coeffici...

Why sometimes you see double? The Monocular Kinematic Overshoot: The Root Cause of Algorithmic Diplopia in the Master-Slave Visual System

Temporary double vision (diplopia) experienced during adaptation to new optical lenses or a change in the focal power of the natural lenses or sudden pupillary aperture shifts is classically misattributed to binocular muscular fatigue or image-size disparity. This paper redefines...

Antimicrobial Resistance, Metal Tolerance, and Virulence Determinants in Gram-negative Opportunistic Pathogens Isolated from Brazilian Groundwater

Abstract Groundwater is a critical freshwater resource, but its quality can be compromised by anthropogenic contamination. Metals may exert selective pressure on microbial communities, promoting metal-tolerant bacteria carrying metal tolerance genes (MTGs), which are often associ...

Forward-KL Learning Curves of Maximum Likelihood Estimators Need Not Be Monotone

Let L_n be the expected forward Kullback–Leibler risk of the maximum-likelihood estimator based on n independent observations from a correctly specified model. We show that L_n need not be nonincreasing, even for a one-dimensional full, regular, minimal natural exponential family...

Hardware-Aware Dynamic Bit-Reordering: Zero-Allocation In-Register Decompression for Analytical Engines

In-memory analytical processing (IMAP) engines face severe performance bottlenecks driven by memory bandwidth saturation and cache pollution. Traditional data compression algorithms mitigate memory consumption but introduce significant CPU overhead through heap allocations, cache...

From materials design to real-world performance in passive radiative cooling paints

Abstract Global warming arises from the net accumulation of solar energy within the Earth–atmosphere system. Passive radiative cooling paints (PRCPs) offer a scalable approach to mitigate this imbalance by reflecting solar radiation and emitting heat to outer space, thereby reduc...

From a Gravity-Calibrated Helix to Neutrino Oscillation Correspondences: A Third Cross-Sector Comparison of the Frozen TEF Shape Parameter

This paper is the third cross-sector comparison in a TEF sequence built around the same dimensionless helical shape parameter q = a/R = 0.556324180045.... The value of q was fixed in Paper I by a gravity-calibrated one-cycle condition, before any neutrino observable entered the a...