Research works

The Geometry of the Self: A Structural Framework for Identity Integration, Psychopathology, and Therapeutic Translation

This paper proposes a structural framework for understanding mental health, identity, and psychotherapy. Traditional approaches treat trauma, anxiety, personality rigidity, and social conflict as separate phenomena, each addressed by different therapeutic modalities. This framewo...

The Divisor Mirror: A Geometric Invariant for Integer Structure

Every positive integer N carries a natural reflection symmetry whose deviations reveal its arithmetic structure. This paper introduces the divisor-mirror imbalance invariant W(N), defined through the total absolute distance of the divisors of N from the square-root axis. By measu...

In-line fiber-integrated photon-pair generation from van der Waals crystals

Miniaturized quantum light sources that operate directly in optical fibers are an attractive platform for optical quantum technologies. However, most miniaturized spontaneous parametric down-conversion (SPDC) sources still rely on objective-lens-based free-space pumping and colle...

Selective culling and the potential persistence of lumpy skin disease in cattle herds: insights from a mechanistic transmission model

Abstract The first epidemic of lumpy skin disease (LSD) in France was detected in June 2025, with a total of 117 outbreaks recorded by the end of the year. This fast-spreading vector-borne disease of cattle prompted the implementation of strict control measures, including total d...

Compositional Controls on the Contribution of (Fe,Al)OOH Solid Solution to Core‐Mantle Boundary Heterogeneities

Abstract Hydrous oxyhydroxides such as FeOOH and AlOOH have been proposed as potential carriers of hydrogen into Earth's deep mantle. However, these phases form extensive solid solutions in natural systems, and the influence of Al incorporation on the stability and elastic proper...

Directional Relational Manifolds: Stratified Variable-Rank Geometry, Rank-Transition Holonomy, Geometric Hysteresis, and Energy-Controlled Transitions

We introduce Directional Relational Manifolds (DRM), a stratified variable-rank geometricframework for systems whose effective degrees of freedom may emerge, collapse, or reorganizewith state. The construction starts from a smooth finite-rank vector bundle E → M, a smoothsymmetri...

Eco-Evolutionary Dynamics of Proliferation Heterogeneity: A Phenotype-Structured Model for Tumor Growth and Treatment Response

Abstract Intra-tumor heterogeneity in proliferation rates fundamentally influences cancer progression and treatment resistance. To investigate how continuous phenotypic variation shapes eco-evolutionary dynamics, we develop a phenotype-structured partial differential equation fra...

Activation of FcγR and classical complement pathways contribute to T-DXd plus pertuzumab therapeutic efficacy

In addition to delivering cytotoxic payloads, HER2-targeted antibody–drug conjugates (ADCs) can engage innate immune effector pathways (such as FcγR and complement) similar to monoclonal antibodies (mAbs). However, the relative contribution of innate pathways to therapeutic benef...

Continued high mortality following diagnosis of HIV-associated Kaposi sarcoma in East Africa in the “Treat All” antiretroviral therapy era ― 2021-2024

Abstract Background Stage at time of diagnosis and survival after diagnosis are critical parameters regarding control of any cancer in any geographical setting. In earlier research focusing on the initial years of the “Treat All” era (2016-2019), we found that HIV-associated Kapo...

Synthetic Anionophores Enhance the Activity of Anionic Drugs

Lipid bilayers pose a major barrier to the passive diffusion of anionic species, including many carboxylate-containing drugs. This limited membrane permeability can reduce drug efficacy and allow bacteria to deploy various defense mechanisms. In this study, we show that small syn...

Deviations from genetic additivity driven by rare variants at biobank scale

Abstract Additive genetic models are the default for genome-wide association studies, but deviations from additivity are crucial for understanding disease mechanisms and therapeutic responses. Yet existing methods for testing nonadditivity are computationally infeasible for large...

A quantum-inspired framework for real-time trust estimation in human–AI interaction: a pilot study

Abstract Trust is a determinant of effective human-AI collaboration, shaping whether users appropriately accept or reject system recommendations. In safety-critical domains, miscalibrated trust can lead to unsafe overrides or uncritical acceptance of erroneous outputs. However, e...

Temporal tuning of continuous flash suppression for 3D objects reflects intrinsic dynamics of visual awareness

Understanding how visual information gains access to conscious awareness is a central issue in cognitive neuroscience. Continuous Flash Suppression (CFS) provides a powerful method to investigate this transition by reliably suppressing visual stimuli from awareness. While previou...

Parietal default mode network connectivity is associated with tobacco use in psychosis

Abnormal default mode network (DMN) connectivity was observed in both tobacco use and psychosis spectrum disorders, but it remains unknown how psychosis impacts the relationship between connectivity and tobacco use. Interventions targeting the left lateral parietal DMN node (LLP...

Cavity-enhanced optical readout and control of nuclear spin qubits

Abstract Their exceptional coherence makes nuclear spins in solids a prime candidate for quantum memories in quantum networks and repeaters. Still, the direct all-optical initialization, coherent control, and readout of individual nuclear spin qubits have been an outstanding chal...

Conserved protein folds underpin the diversification of secreted proteins in a fungal pathogen

Abstract Background During host colonization, fungal plant pathogens secrete effector-like proteins that alter host cell physiology and target plant-associated microbes. However, rapid evolution and low sequence conservation hinder the study and characterization of these proteins...

Projection-Layer Clarification and Ongoing Research Direction in the General Theory of Entirety (GTOE)

This companion statement preserves domain distinctions established in GTOE Whitepaper v2.3 and clarifies the separation between origin-layer coherence (č²) and projection-layer geometry (X², its resultant (0)¹, and measurable constants). Two corrections of placement are recorded....

Risks of adverse respiratory outcomes in adults with cancer over the course of survivorship compared with cancer-free individuals: a matched cohort study using linked English electronic health records

Background We aimed to compare the risks of developing new chronic respiratory conditions, or exacerbating existing ones in survivors of 20 common cancers vs. cancer-free individuals. Methods We conducted a population-based matched cohort study using English electronic primary ca...

AI transformation, resource reallocation, and corporate capacity utilization

Artificial intelligence (AI) is reshaping the global economic landscape, prompting China to initiate a new wave of AI application pilot programs. Using the AI Application Pilot Zones policy as a quasi-natural experiment, this study examines the impact of an AI-driven transformati...

Generating a national snapshot of all publicly reported investments in ecosystem and species conservation across public, private, and philanthropic finance

Abstract Scaling up investment in ecosystems is a national and international public policy priority. Evaluations of the total amount spent have been severely criticised, with a lack of transparent reporting, especially of private finance flows, a known limitation. We provide a co...