Research works

Potential Role of Sphingosine-1-Phosphate and Its Receptors in the Reparative Processes of the Adult Brain

This review highlights the main aspects of the involvement of sphingosine-1-phosphate (S1P) metabolism in the reparative processes of the adult brain, including neurogenesis, oligodendrogenesis and angiogenesis, which are necessary for the normal functioning of the central nervou...

Strain-Specific Reduction of Ndel1 Enzymatic Activity During Early Zika Virus Infection in the Neonatal Brain

Zika virus (ZIKV) infection during early development is associated with severe neurodevelopmental impairment, including congenital microcephaly, yet the molecular mechanisms linking viral exposure to neuronal dysfunction remain incompletely understood. Ndel1 (nudE neurodevelopmen...

Bodies out of place? A reflexive autoethnographic account of women's cricket spectatorship in India

Women's cricket in India is increasingly celebrated as a symbol of national progress and gender inclusion, yet women's experiences as spectators remain underexamined. Drawing on postcolonial feminist theory and reflexive autoethnographic observations, this article presents a situ...

Safeguarding the Past, Building the Future: A Collaborative Model for Ensemble-based Heritage Conservation in Barbados

Co-led by the Barbados National Trust (BNT) and the Division of Culture (DOC), Prime Minister's Office, this project is developing a multi-institutional, intergenerational framework for the conservation and site management of Tyrol Cot – a nationally significant heritage property...

Synthesis of Unsymmetrical Alkyl Carbonate from Diethyl Carbonate and Benzyl Alcohol with N-Doped Carbon-Supported Iron Oxide Catalysts

Developing simple and efficient heterogeneous catalysts for transesterification of dialkyl carbonates with alcohols is very significant for achieving green syntheses of unsymmetrical alkyl carbonates. Here, a set of N-doped carbon material (NCM)-supported iron oxides was prepared...

Synthesis, Anticancer Evaluation, mRNA Expression Analysis, and Molecular Docking of Fluorinated Picolinamide–Benzothiazole Derivatives Against Breast Cancer‐Related Genes CDK2, ERK2, and BCL2

ABSTRACT The present study focuses on the design, synthesis, characterization, and biological evaluation of two new series of derivatives 4‐(4‐amino‐3‐fluorophenoxy)‐N‐methylpicolinamide ( 3a–e ) and 2‐aminobenzothiazole ( 5a‐e ) as potential antioxidant and anticancer agents. Th...

Property rights and the provision of rural public goods: evidence from China’s rural collective property rights system reform

Property rights reform is expected to mobilize multiple actors to actively participate in rural governance, thereby exerting an important influence on the provision of rural public goods. This study examines the impact of China’s Rural Collective Property Rights System Reform (RC...

Carrier-free nanoparticles for cancer therapy: assembly strategies, therapeutic applications, and clinical translation

Carrier-free nanoparticles have emerged as a promising class of nanomedicines for cancer therapy, characterized by ultrahigh drug-loading capacity, reduced dependence on inert carriers, and enhanced therapeutic efficiency. Diverse design strategies, including molecular self-assem...

Association of baseline and cumulative cholesterol–high-density lipoprotein–glucose index with cardiometabolic multimorbidity: prospective evidence from two cohort studies

Abstract Introduction Cardiometabolic multimorbidity (CMM) is increasingly common and carries substantial clinical and public-health burden. The cholesterol-high-density lipoprotein-glucose (CHG) index has been linked to adverse cardiometabolic outcomes, but prospective evidence...

Marks-versus-Percentile Data: A Simple Mathematical Analysis Based on a Hypothetical Dataset

This study presents a simple mathematical method for analysing examination-related data and describing the overall performance of a group. A hypothetical dataset of scores and percentile values is used to demonstrate the method. An empirical formula is fitted to the percentile da...

Engineering Hidden Ferroelectric‐Like Distortion for Ultralow Thermal Conductivity in Polar van der Waals Tetradymite

ABSTRACT Ferroelectric‐like polar structures enable diverse functionalities through coupling with charge and phonon transport. Although effective in modulating thermal conductivity, the rational design of novel polar materials with intrinsically low thermal conductivity via ferro...

Semantic information from smashed data: text reconstruction attack on phishing detection models in split learning

Phishing attacks via desktops, smartphones and internet of things devices are becoming increasingly sophisticated, posing critical security challenges for digital infrastructures. Defending against these attacks requires AI-based detection models that maintain high accuracy, sinc...

Discovery and Characterization of Inhibitors of Ubiquitin-Like Modifier Activating Enzyme 5 (UBA5): Targeting the UFMylation Pathway in Cancer and Neurodegenerative Diseases

Abstract UBA5 is the E1 enzyme that initiates UFMylation, a ubiquitin-like modification implicated in proteostasis, neurodegeneration, and cancer. Here, we report a chemical biology approach to interrogate UBA5 function through small-molecule inhibition. We developed a robust hig...

Formal Pressure Testing a Relation-First Ontology: Representability, Non-Canonicity, and Structural Limits - The Universal Recursive Dynamics Case

This release presents an Open Specialist Assessment Version of a formal pressure test concerning selected commitments of Universal Recursive Dynamics (URD) and categorical, dependent, history-sensitive, and process-theoretic resources used to represent them without collapsing str...

Is there a role for listening as we work to ameliorate the current crisis in higher education?

In my view, leadership and faculty in higher education (HE) strongly believe that listening is vital. However, despite our recognition that listening is essential, our efforts to listen deeply to t...

OsWOX13 functions as a heading signal transducer from integrator Ehd1 to florigen for the accurate regulation of rice heading date

Abstract Appropriate heading date is an important safeguard for stabilizing rice yield and quality. Heading integrator Ehd1 and florigen Hd3a are crucial for rice heading. However, the mechanism by which Ehd1 transmits heading signals to Hd3a and the accurate regulation of Hd3a e...

Phi-Modulated E8 Lattice Phase as Origin of High‑Tc Superconductivity — E8 Intelligence Research

The discovery shows that the 240 E8 root vectors can be grouped into phi‑coupled resonance clusters that generate a discrete phase manifold governing a superconducting transition. When this manifold reaches saturation it emits a stable 132 Hz acoustic tone, providing a direct sig...

3D-Printed Poly(ε-Caprolactone)/CaCO3 Biocomposite Meshes for Bone Tissue Engineering: EnhancedMechanicalStrength and Cytocompatibility

Abstract Poly(ε-caprolactone) (PCL) is a biodegradable and biocompatible polyester widely used in biomedical scaffolds. However, its relatively low mechanical strength and limited cell adhesion properties remain major challenges for bone tissue engineering applications. This stud...

Impact of Global Value Chain Participation on Financial Efficiency of Indian Steel Industry

The Indian steel industry plays a crucial role in economic development, infrastructure growth, and industrial expansion. With globalization, the integration of steel firms into the Global Value Chain (GVC) has significantly influenced their financial efficiency and competitivenes...

Vietnamese private international law on marriage and family relations: a feminist legal perspective

It is usually believed that Private international law (PIL) is a neutral field of law in which gender factors are not expressed. However, is this belief really right? The article evaluates the impact of PIL regulations on the rights of women in marriage and family relationships,...