Research works
The research papers we track — the newest first. Works with a plain-language summary link to it.
138309 work(s)
- Health & MedicineOpen access
Introducing diabetes emotional well-being into routine consultations for adults with type 2 diabetes
Abstract Aims/hypothesis To generate initial programme theories explaining how assessment and discussion of diabetes distress could be embedded into routine type 2 diabetes care, providing a theoretical foundation for future evaluation and implementation. Methods A rapid realist...
- Climate & EnvironmentOpen access
Abstract. Nitrous oxide (N2O) and methane (CH4) are potent greenhouse gases for which oceanic contributions remain uncertain, particularly in undersampled regions like the Southwest and Southeast margins of the Mediterranean Sea, where there is a major observational gap. This dat...
- BiologyOpen access
Accessing deeply buried binding sites remains a major challenge in structure-based drug discovery, where accurate description of both protein dynamics and ligand binding pathways is required. All-atom funnel metadynamics (AA-FMD) enables simulation of complete binding processes b...
- Climate & EnvironmentOpen access
Year-Round High-Resolution Sea Ice Freeboard Retrieval Using ICESat-2 ATL03 Photon Data
Abstract. Arctic sea ice freeboard is critical for estimating ice thickness and characterizing surface morphology, yet it remains poorly constrained, especially during the melt season due to limitations in conventional altimetry products. The ICESat-2 ATL07 product retrieves surf...
- Biology
Abstract In nematode sperm, motility is powered by polymerization of major sperm protein (MSP) into filaments assembled from a specialized organelle (FB–MO), but how filament formation begins is unclear. We identify two sperm-specific PDZ proteins, SMZ-1 and SMZ-2 (SMZ-1/2), that...
- BiologyOpen access
Population morphology implies a common developmental blueprint for Drosophila motion detectors
Abstract T4 and T5 neurons are the first direction-selective neurons in the visual pathway. They are the most numerous cell types in the fly brain (∼ 6000 within each optic lobe) and, as a population, their compact dendritic arbours span the entire visual field. They are classifi...
- BiologyOpen access
ABSTRACT Debaryomyces hansenii is a yeast with diverse potential applications like producing oleochemicals from biomass. Yet, combinatorial metabolic engineering in D. hansenii is limited because, like many nonconventional organisms, key genomic data and genetic elements are miss...
- Health & MedicineOpen access
The nutrient-sensing mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway controls cellular and organismal growth and metabolism, while aberrant activation is linked to human disease, including metabolic disease. Cellular studies have established several regulator...
- BiologyOpen access
Podocyte injury damages podocytes in chimeric organoids
Abstract We have previously shown that injury to a subset of podocytes can trigger secondary damage in neighboring podocytes, but whether this phenomenon depends on direct intercellular interaction is unknown. To address this, kidney organoids were generated from nephron progenit...
- Society & EconomicsOpen access
Subicular spatial codes arise from predictive mapping
Abstract The successor representation has emerged as a powerful model for understanding mammalian navigation and memory; explaining the spatial coding properties of hippocampal place cells and entorhinal grid cells. However, the diverse spatial responses of subicular neurons, the...
- BiologyOpen access
Convergent latitudinal erosion of circadian systems in a rapidly diversifying order of fishes
Abstract Biological clocks enable organisms to anticipate cyclical environmental changes. Some habitats, such as those at high latitudes or deep sea, experience seasonally diminished or absent diel cues upon which species entrain their circadian rhythms. Fishes of the order Perci...
- Health & MedicineOpen access
Repositioning of polyubiquitin alters the pathologic tau filament structure
Abstract Structurally diverse tau filaments form proteinaceous aggregates in a heterogeneous group of neurodegenerative diseases called tauopathies 1 . The factors extrinsic to the highly ordered core structure that influence tau filament stability are not well understood. Here,...
- BiologyOpen access
Abstract Hematopoiesis is a complex process that begins with hematopoietic stem cells (HSCs) that progressively differentiate into the cellular components found in blood. Dogs develop spontaneous, biologically similar hematopoietic diseases as humans, yet transcriptomic maps of n...
- Health & MedicineOpen access
ABSTRACT Human cytomegalovirus (HCMV) is a β-herpesvirus that is ubiquitous in the human population. HCMV has the largest genome of the human herpesviruses and encodes an array of genes that affect pathogenesis in different cell types. Given the ability of HCMV to replicate in a...
- BiologyOpen access
Abstract Visuomotor association involves linking an arbitrary visual cue to a well-learned movement. Transient inactivation of Crus I/II impairs primates’ ability to learn new associations and delays motor responses without affecting the kinematics of the movement. The simple spi...
- AI & ComputingOpen access
Open source intelligence is a powerful tool for cybersecurity analysts to gather information both for analysis of discovered vulnerabilities and for detecting novel cybersecurity threats and exploits. Here, we present a Neo4j graph database formed by shared connections (shared su...
- BiologyOpen access
Autistic neural ‘shiftability’: the distinct pharmacological landscape of the autistic brain
Functionally inter-connected large-scale brain networks regulated by multiple neurotransmitter systems underpin complex human behaviour. A wide range of alterations in this neurofunctional landscape have been associated with autism. However, this evidence is mostly derived from c...
- BiologyOpen access
ABSTRACT Male and female unisexual flowers have repeatedly evolved from the ancestral bisexual flowers in different lineages of flowering plants. This sex specialization in different flowers often occurs within inflorescences. We hypothesize that inflorescence architecture may im...
- Society & EconomicsOpen access
The Causal Effect of Parents' Education on Children's Earnings
ABSTRACT We develop and estimate a model of endogenous schooling and earnings to isolate the causal effect of parents' education on children's outcomes. Identification uses earnings differences among children with equal schooling whose parents have different schooling. Health and...
- Society & EconomicsOpen access
Bilingual chronicle (German/English) of the first publications of the AUGMANITAI / Universal Concept Layer research programme, January to August 2026. Every link of the chain is attested by at least one independent third party: Internet Archive snapshots (including the programme...