Research works

Orbital migration and heating history of the Galactic disc: a transition between the bimodal discs

Stellar orbits in the Galactic disc evolve from their birth to the current shape through both radial migration and dynamical heating. The history of their secular evolution is imprinted in the current kinematics and age-metallicity distribution. We construct a chrono-chemo-dynami...

Navigating Human Astrocyte Differentiation:Direct and Rapid One-Step Differentiation of Induced Pluripotent Stem Cells to Functional Astrocytes Supporting Neuronal Network Development

Astrocytes play a pivotal role in neuronal network development. Despite the well-known role of astrocytes in the pathophysiology of neurologic disorders, the utilization of induced pluripotent stem cell (iPSC)-derived astrocytes in neuronal networks remains limited. Here, we pres...

Distinct Temporal Stages of Infant Brain Processing Associate With Early Versus Later Autism Diagnosis

The expression of autism traits sufficient to meet criteria for a diagnosis can occur early (by 3 years) or later (from mid-childhood onwards). It remains unknown whether variation in age of onset is due to clinical recognition or reflects distinct biological pathways. One way of...

Use of Attention Deficit Hyperactivity Disorder Medication Among Danish Children and Adolescents From 2010 to 2023

Introduction: Pharmacological treatment is an important component in the multimodal management of attention deficit hyperactivity disorder (ADHD), but contemporary trends in ADHD medication use among boys and girls in Denmark have not been fully characterized. This study aimed to...

Sichuan dark tea with a medicine-food-homology formula synergistically alleviates alcohol-associated gut microbiota disturbance, liver steatosis and death in mice

Alcohol-associated liver disease (ALD) is a global health concern. Sichuan dark tea, a popular Chinese beverage, has been reported to have good health effects. In the study, Sichuan dark tea with a medicine-food-homology formula (TEA&MFH) has been created and evaluated for potent...

Emergent spatiotemporal dynamics in large-scale brain networks with next generation neural mass models

Understanding the dynamics of large-scale brain models remains a central challenge due to the inherent complexity of these systems. In this work, we explore the emergence of complex spatiotemporal patterns in a large-scale brain model composed of 90 interconnected brain regions c...

Manufactured Recognition: AI Companions and the Social Conditions of Reciprocity

AI companion services offer continuing, personalized conversation as friendship or intimacy. Their relational features are also product choices: providers configure personas, memory, access, and the criteria by which responses are selected. Drawing on product documentation, a dev...

[TI-2.03] A Set of Visual Signatures on the Border Band of the Frontal Image of the Sarcophagus Lid of Pakal: Distribution of Signs over the Intra-group Edges of the Cubic Graph

The cubic graph obtained at the preceding stage from a set of visual signatures of the Tzolk'in system contains connections of two kinds: between nodes of different groups and within groups. The inter-group connections were placed in the previous work; the present work sets the t...

A Study on Thermomechanical Stress Analysis and Fatigue Life Prediction of High-power LED Packages for Railroad Signals

철도 신호 시스템이 LTE-R과 같은 All-IP 기반 인프라로 전환됨에 따라, 고출력 LED 신호기의 신뢰성은 안전무결성수준(SIL 4) 확보에 필수적이다. 이에 본 연구는 Suhir 이론을 바탕으로 고출력 LED 패키지의 열-기계적 응력 및 피로 수명을 예측하는 수치 해석 모델을 제안한다. 열화상 기반 접합 온...

Mandibular cortical morphology on dental panoramic radiographs as a potential radiographic marker of frailty in community-dwelling older adults: a retrospective cross-sectional study

Frailty is a multifactorial geriatric syndrome associated with functional decline and adverse health outcomes in older adults. Panoramic radiography is routinely performed in dental practice and enables incidental evaluation of mandibular cortical morphology without additional im...

Beyond “Picky Eating”: Identification, Screening, and Referral for Pediatric Feeding Disorders in Primary Care

Pediatric feeding disorders (PFDs) affect 1 in 37 children under age 5 in the United States, representing a common yet frequently underrecognized condition in primary care. In 2019, a multidisciplinary expert panel established the first consensus definition of PFD, creating a sta...

Cohort-level discrepancy between observed and model-based pedicle screw loosening risk: an exploratory aggregate-data evaluation of the explanatory gap index

Published pedicle screw loosening (PSL) cohorts differ substantially in observed event rates, predictor measurement, surgical context, and outcome ascertainment. We evaluated whether an aggregate discrepancy index can describe how far an observed cohort result lies from a common...

Real-Augmented Mixed Training for Wheel-Flat Geometry Classification under Data Scarcity on a Laboratory-Scale Test Rig

Accurate defect classification requires sufficient data; however, early-stage studies often face data scarcity when acquiring data through field measurements. This paper proposes a real-augmented mixed training strategy on a 3D-printed, laboratory-scale railway test rig for wheel...

Transforming Chemical Safety Policy in the AI Era: A Seven-Action Strategy for the Five Chemical Safety Acts Under the Ministry of Climate, Energy, and Environment

Chemical safety in the Republic of Korea is governed by five acts falling under the purview of the Ministry of Climate, Energy, and Environment (MCEE): the Act on Registration and Evaluation of Chemicals (K-REACH Act), the Chemicals Control Act (CCA), the Environmental Health Act...

Subanesthetic nitrous oxide alters large-scale network organization and insula connectivity during visual stimulation

Pharmacological agents that alter consciousness, including classic psychedelics and non-classic agents such as nitrous oxide, are known to affect multiple domains of conscious experience, including visual perception. While most neuroimaging studies rely on resting-state data to c...

PI3K/AKT signaling pathway: molecular crossroads in tumorigenesis and therapeutic innovation

The PI3K/AKT signaling pathway serves as a pivotal regulatory hub that governs essential cellular processes, including growth, proliferation, metabolism, survival, and migration. In the context of tumorigenesis and cancer development, aberrant activation of this pathway drives ma...

Interference Analysis and Performance Improvement based on RAN Sharing in LTE-R and PS-LTE Coexistence Environment

우리나라는 700MHz 대역 LTE 기반으로 PS-LTE, LTE-R, LTE-M을 통합 운영하는 공공무선통신망 정책을 추진 중이다. LTE-R은 2017년 원주–강릉 구간을 시작으로 구축되어 2027년까지 전 철도 노선 적용을 목표로 한다. LTE-R(UL 718–728MHz, DL 773–783MHz)은 PS-LTE와 동일 주파수를 공유하여 동일채널...

Profiles of stressful life experiences in pregnancy: a latent class approach linking early childhood adversity, intimate partner coercive control, and material hardship to adverse birth outcomes

Acute antenatal stressful life events (SLEs) during pregnancy are well-established risk factors for adverse birth outcomes. However, little is known about how distinct constellations of antenatal SLEs, shaped by early adversity, material hardship, and intimate partner coercive co...

Comparative Analysis of Mass and Number Concentration Characteristics of Non-Exhaust Particulate Matter (Airborne Wear Particles) Generated from Wheel-Rail Contact

도시 철도 터널 공기는 철도 차량 운행 중 발생하는 비배기 미세먼지, 특히 휠-레일 접촉에서 발생하는 미세 마모 입자에 의해 심하게 오염되어 있다. 본 연구에서는 이러한 휠-레일 접촉 미세 마모 입자의 발생 특성을 규명하기 위하여 Twin-disk rig를 활용한 모사 시험을 수행하고, 발생 입자의 수...

ROX index and NEWS2 for 28-day mortality prediction in emergency department patients with acute dyspnea: a prospective observational study

Acute dyspnea is a frequent and high-risk presentation in emergency departments (ED), requiring rapid identification of patients at increased risk of deterioration and mortality. This study aimed to compare the accuracy of the Respiratory Rate–Oxygenation (ROX) index and National...