Research works

Urolithin A mitigates doxorubicin-induced myocardial injury via suppression of ROS-driven apoptotic signaling.

BACKGROUND: were investigated. METHODS: protective mechanism. RESULTS: . CONCLUSION: by inhibiting ROS-driven apoptosis, which yields significant insights for combating DOX-mediated myocardial injury.

Quantitative Lessons from Russian Formalism: Contextualizing Boris Yarkho’s Legacy in Contemporary Debates on Digital Humanities

info:eu-repo/semantics/inPress

Protective effects of Abelmoschus manihot flower extracts against blue light-emitting diode light-induced retinal photoreceptor cell damage in vivo and in vitro.

BACKGROUND: flower extract (AME), rich in flavonoids, possesses antioxidant and anti-inflammatory properties; however, its protective effects on the retina have not been fully elucidated. METHODS: analyses included cell viability assays, TUNEL staining, reactive oxygen species (R...

Crop genotypic richness enhances biomass production and phosphorus acquisition in maize‐mycorrhiza symbiosis

Societal Impact Statement: Our study tests how soil and plant biodiversity can enhance sustainability of crop production in Kenya. We tested whether mixtures of maize varieties performed better than monocultures and tested their response to arbuscular mycorrhizal fungi. Mycorrhiz...

Advances and challenges in developing expandable human hepatocytes for regenerative medicine.

Liver transplantation remains the only effective treatment for severe liver disease, but donor shortages pose a serious challenge, underscoring the need for alternative therapeutic strategies. Hepatocyte transplantation has been proposed as a promising alternative; however, the l...

Acupuncture alleviates the progression of lumbar disc herniation by regulating the autophagy level of nucleus pulposus cells through the SIRT1/Sestrin2 pathway.

BACKGROUND AND PURPOSE: Lumbar disc herniation (LDH) is a degenerative spine disease and the most common cause of lower back pain, with a high prevalence in younger patients. The use of acupuncture (AC) as a conservative treatment for LDH has received widespread attention at home...

Consensus document on electroencephalography education in anaesthesiology: defining learning outcomes: A modified four-round Delphi study.

Background The brain is the primary target of general anaesthesia, yet routine brain monitoring remains underutilised. Although electroencephalography (EEG) is increasingly recognised as an important tool for assessing brain states during anaesthesia, inconsistent training and ov...

Beyond cytoskeletal regulation: Rho-associated, coiled-coil-containing protein kinase 2 in kidney inflammation and fibrosis.

Chronic kidney disease (CKD), histologically defined by glomerulosclerosis, tubular atrophy, interstitial fibrosis, and capillary rarefaction, represents a profound challenge in cellular pathology. This review synthesizes recent advances to position Rho-associated, coiled-coil-co...

Hiatus as a Dating Criterion for Hanno's Periplus

I have no wish to enter into the debates over the origin, authorship, or date of Hano's Periplus, nor those over its status as a translation or as a summary, except to make this one observation: the author avoids hiatus with the same strictness as Plato in his 'late' works and De...

Tyrosine protein kinase ABL1 regulates the mTOR/ULK1 pathway to alleviate postoperative cognitive dysfunction in aged mice.

BACKGROUND: Postoperative cognitive dysfunction (POCD) is a common and serious complication in older adult patients. While the tyrosine kinase ABL1 has been implicated in neurodegenerative diseases, its specific role in POCD remains unexplored. This study aims to investigate whet...

Sensory Framework for Studying Tourist practicess in the Heat

This research note introduces a sensory framework that highlights heat as a key embodied and ethical aspect of tourist practicestravel and points to new directions in studying experiences of and practices in the heat. The framework is introduced in response to an era of global he...

Infinite splitting in the syzygies of quaternionic groups

→ F 0 → R → 0) be a free resolution over the group ring R[Φ] where R is commutative and Φ is finite.The n th syzygy Ω R[Φ] n is the stable class of Im(∂ n ) and has a tree structure with roots which do not extend infinitely downwards.We show that Ω R[Q8p] 3 has infinitely many is...

Evaluating the Effectiveness of a Practitioner-Designed Science-Based Interviewing and Interrogation Course : A Collaborative Training and Research Effort

Purpose Shifting interrogation approaches in the United States from accusatorial practices to science-based methods has been a challenge. The High-Value Detainee Interrogation Group (HIG) research programme has taken a translational approach to evaluating the efficacy and effecti...

Applied Machine Learning for CNS Clinical Trial Risk Assessment: An Interpretable Framework with an ALS Case Study

This technical report presents an applied framework for assessing risk in central nervous system (CNS) clinical trials, emphasizing interpretable, structured decision-making using biological, clinical, and operational signals. The platform integrates curated trial metadata, bioma...

Applied Machine Learning for CNS Clinical Trial Risk Assessment: An Interpretable Framework with an ALS Case Study

This technical report presents an applied framework for assessing risk in central nervous system (CNS) clinical trials, emphasizing interpretable, structured decision-making using biological, clinical, and operational signals. The platform integrates curated trial metadata, bioma...

Perfectionism: Secondary pupils’ perceptions of pressures contributing to perfectionism, and its relationship with emotional wellbeing

This sequential mixed methods study explored experiences and perceptions of perfectionism in a sample of secondary aged children and adolescents. Phase 1 assessed the relationship between different domains of perfectionism and depression and anxiety in 114 pupils reporting high l...

‘A matter that stirs strong feelings’: Britain and the Soviet Wives Affair, 1945-54

Historians tend to ascribe the onset of the Anglo-Soviet Cold War in the wake of the German defeat in 1945 to matters such as differences over Eastern Europe, but certain other influences have not received much attention. In particular, strains arose from how thirty-four Service...

Play

Play is one of the most celebrated activities in life, and a complex, fascinating, and disputed phenomenon. Because of the great variation in expressions and forms of play, definitions of play are hard to agree upon. Play research is interdisciplinary and engages various domains...

Regulation of G Protein Signaling 14 protects against cerebral ischemic reperfusion injury by inhibiting the TAK1-JNK/p38 signaling pathway.

BACKGROUND: Stroke is a crucial cause of morbidity and mortality worldwide. The regulator of G protein signaling 14 (RGS14) plays important roles in mediating multiple signaling pathways and various pathophysiological processes. However, the function of RGS14 in cerebral ischemic...

Roles of spinal V3 interneurons: Roles in controlling movement in healthy and injured conditions.

Spinal V3 interneurons are glutamatergic neurons that are distributed among the dorsal, intermediate, and ventral spinal cord. They are involved in broad neural circuit connections in the central nervous system. Functionally, they play important roles in locomotion, such as the m...