Research works

The clinicopathological and molecular characterization in ascites-derived paraffin-embedded cell blocks of ovarian cancer

Abstract This study evaluated immunohistochemical (IHC) markers and homologous recombination repair (HRR) gene mutations in 58 ovarian cancer patients using ascites-derived paraffin-embedded cell blocks. IHC analysis revealed high expression of Pax-8 (87.5–100%), WT-1 (87.8–90%),...

Paleoenvironmental and paleoclimatic reconstruction in the Western Mediterranean during the Late Early Pleistocene

Abstract. The major climate change recorded during the Early-Middle Pleistocene Transition (1.4–0.4 Ma) is characterized by an increase in the length of climatic cycles from 41 to 100 ka. During this period, the Mediterranean climate underwent aridification associated with a drop...

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Abstract Background Cyclin-dependent kinases drive the progression through the cell cycle and thereby form classical targets for cancer therapy. In prostate cancer (PC), the first line of therapy typically targets androgen receptor (AR), but it frequently leads to development of...

Evaluation of natural and synthetic photosensitizers in visible light-mediated antimicrobial photodynamic therapy against pathogenic bacteria

Antibiotic resistance is the most alarming issue in medicinal treatment against bacterial infections. Alternative effective treatment solutions to antibiotics are long overdue. Long standing antibiotic overuse and unfinished antibiotic courses have become globally life threatenin...

Population genomics, resistome and plasmidome of invasive Klebsiella pneumoniae isolates in adults hospitalised in Johannesburg, South Africa

Abstract Klebsiella pneumoniae (KPn) is a leading cause of healthcare-associated infections in adults in low- and middle-income countries. We conducted laboratory-based surveillance between 2023 and 2024 in Johannesburg, South Africa, and analysed 508 KPn whole genomes isolated f...

Remote engineering of particle-like topologies to visualise entanglement dynamics

Abstract Skyrmions are a particle-like topology with a quantized skyrmion number, realized across condensed matter and photonic platforms alike. In quantum photonics, they constitute an emerging resource, promising robust quantum information encoding, so far realized as single-ph...

Measurement of binding antibodies to SARS-CoV-2 variants elicited by natural infection and COVID-19 vaccines in a sub-Saharan African population

Abstract Data on immune responses to COVID-19 vaccination in West and Central Africa remain limited, particularly with respect to antibody (Ab) binding across SARS-CoV-2 variants and for different types of vaccine platforms. We assessed anti-spike (anti-S) antibody binding to nin...

The Reproducibility Promotion Plan for Funders–a co-created set of recommendations to foster reproducible research practices

Abstract Reproducibility is a critical component of research integrity, enhancing the quality, efficiency and trustworthiness of scientific knowledge. Despite increasing attention, reproducibility remains insufficiently prioritized within the scientific agenda. Research funders a...

Longitudinal spatial multi-omics delineates tumor microenvironment remodeling across sequential EGFR-TKIs in EGFR-mutant NSCLC

Abstract Background Resistance to therapy is a frequent occurrence in patients with epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) who are treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, spatial information on how the tumor mi...

Empirical mathematics in Australian Indigenous smoke telegraphy

Mathematics curriculums at most universities tend to perpetuate a belief that higher mathematics is historically and culturally European. First Nations and minority students may not see their identities and cultures reflected in the discipline, yet university mathematics educator...

Get With The Guidelines–Heart Failure Hospital Participation and Its Association With Guideline-Directed Medical Therapy and Outcomes

Abstract Purpose Despite strong evidence, real-world adoption of guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) remains suboptimal. The Get With The Guidelines–Heart Failure (GWTG-HF) program was designed to close gaps in care....

Design and experimental investigation of a heat pump-assisted double-effect evaporation system using ethanol as the working fluid

Most existing studies on the evaporation process of ethanol solutions focus on the microscopic scale, with a lack of research on design calculation methods and operational characteristics targeting macroscopic systems. This study proposes a heat pump-assisted double-effect evapor...

Diverse microbial metal resistance and novel metal cycling organisms in copper/nickel mine tailings

Abstract Mine tailings contribute to environmental heavy metal contamination through the formation of acid mine drainage (AMD). Microbially-mediated processes such as iron and sulfur redox cycling influence metal mobility. Here, we applied an integrated metagenomic and metaproteo...

From quantitative modeling of fluorescence experiments on biomolecules to the prediction of spectroscopic dye properties

Fluorescence spectroscopy and modeling provide powerful means to characterize biomacromolecular structures, dynamics, and interactions. Förster resonance energy transfer serves as a key technique for this because of its nanometer scale distance sensitivity. Quantitative interpret...

Maxwell kinematical algebras and 3D gravities

Abstract In this paper, we present a Maxwell extension of kinematical Lie algebras by promoting the contraction method underlying the Bacry and Lévy-Leblond cube to a semigroup expansion framework. Within this approach, we show that both non- and ultra-relativistic Maxwell algebr...

An experimental campaign to measure turbulence in the marine boundary layer

Abstract. There is a lack of measurement data on the spatial structure of turbulence at heights greater than 100 m in the marine atmospheric boundary layer (MBL). Consequently, turbulence models like the Mann and Kaimal models, which are referred to in industry standards, have no...

How curriculum modifications shape educational pathways: Evidence from linked administrative data in Switzerland

Abstract The increasing heterogeneity of learning needs and preconditions in inclusive mainstream classrooms entails that not all learners are equally able to meet the regular learning objectives. In response, various integrative measures have been implemented to tailor instructi...

Implementation of the Generalized Double-Moment scaling Normalization method for raindrop size distribution in a WRF 4.3.1 bulk-type cloud microphysics scheme: a case study over the Korean Peninsula

Abstract. This study is the first to adopt the Generalized Double-Moment scaling Normalization (GDMN) method to represent the rain Drop Size Distribution (DSD) in a bulk-type cloud microphysics scheme, specifically the Weather Research and Forecasting (WRF) Double-moment 6-class...

Low depth unitary coupled cluster algorithm for large chemical systems

The unitary coupled cluster (UCC) algorithm is one of the most promising implementations of the variational quantum eigensolver for quantum computers. However, for large systems, the number of UCC factors leads to deep quantum circuits, which are prohibitive for execution on quan...

Sensitivity of 510(k) medical device filings to government shutdowns: a brief communication

Abstract Government shutdowns may impose indirect regulatory costs on medical device manufacturers by disrupting FDA review processes. This study examines changes in 510(k) review durations surrounding the 2013 and 2018 U.S. government shutdowns. We identify significant increases...